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All Journal journal of internal medicine Berkala Kedokteran Jurnal Ilmiah Kedokteran Wijaya Kusuma Pena Justisia: Media Komunikasi dan Kajian Hukum

Heru Cahjono

University Of Ciputra

Author-ID : 245232

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health

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Articles

HUBUNGAN RESISTENSI INSULIN DENGAN KADAR NITRIC OXIDE PADA OBESITAS ABDOMINAL Cahjono, Heru; Gde Budhiarta, Anak Agung
journal of internal medicine Vol. 8, No. 1 Januari 2007
Publisher : journal of internal medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (442.212 KB)

Numerous studies that confirmed the important link between central obesity and endothelial dysfunction (ED) is furthersupported by the concept that insulin sensitivity is partly determined by the ability of endothelium to produce nitric oxide (NO).In this condition, HOMA-IR, the model which is a convenient means of evaluating insulin resistance has thus far been related toED. Nitric oxide plays important physiological roles in the endothelium, where free radical NO is synthesized from the aminoacid l-arginine by endothelial constitutive NO synthase (eNOS) and released. Endothelium-derived NO is a potent vasodilator aswell as an inhibitor of platelet aggregation and adhesion, and is associated with the development of cardiovascular disease (CVD)in the presence of endothelial dysfunction (ED), which plays an early and prominent role in atherosclerotic plaque formation. Weraised the question as to whether insulin resistance in the abdominal obesity group had association with NO levels contribute toaffect endothelial dysfuntion. Cross sectional study had been conducted during January until March 2007. The study involved 67employees at Sanglah Hospital with abdominal obesity using criteria for Asian people (male WC 90 cm; female WC 80 cm).Serum concentrations of NO metabolites were evaluated through the measurement of metabolic end products, ie, nitrite andnitrate, using enzymatic catalysis coupled with Griess reaction, Serum concentration of insulin was measured by immunoassaymethod. Plasma glucose, cholesterol, HDL-cholesterol, LDL-cholesterol and triglicerydes were determined by enzymatic procedureafter overnight fast. The study involved 45 female and 25 male subjects, 23-56 years of age. Insulin resistance had associationwith waist circumference (r=0,511; p <0,01) and there was no association between insulin resistance and NO titer (r=0,054;p<0,664) but after adjusted with ESR 20-30 mm/h r=-0,486; p<0,048. However, serum concentrations of NO did not have associationwith component of metabolic syndrome and neither did insulin resistance. The present data indicate there is no associationbetween insulin resistance and NO levels except for ESR 20-30 mm/h. This possibility is due to low grade chronic inflammationrole on the pathogenesis of endothelial dysfunction in obesity

Correlation of Vitamin D with Ferritin in Pregnant Mothers Chronic Energy Deficiency of the Second Trimester Hendera Henderi; Salmon Charles P T Siahaan; Irwin Priyatna Kusumah; Heru Cahjono; Ferdinand A Tannus; Nimas Pristiwanto D S; Helen Octavia
Berkala Kedokteran Vol 17, No 2 (2021)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Based on the prevalence of the Kediri Health Office in 2013 and 2014, pregnancy in CED in Kediri was 6.6% and 6.7%, which was an increase of 0.1% from the previous year. According to the prevalence of CED pregnancy in Badas Puskesmas in 2013 and 2014, it was 7.8% and 6.1%. Aimed at knowing the differences in vitamin D levels in normal pregnancy with second trimester CED pregnancy; know the difference between ferritin in normal pregnancy and second trimester CED pregnancy; know the correlation between vitamin D and ferritin in normal pregnancy and second trimester CED pregnancy; know the correlation between vitamin D and UAC in normal pregnancy and second trimester CED pregnancy. This study used an analytical test (case-control) with randomization of pregnant and pregnant CED patients in the Sukomanunggal district. The results showed that the difference in Vitamin D (33.5380 ± 5.60498 vs 32.4300 ± 4.40708) p = 0.166, the comparison was not significant. The difference in ferritin (17.4080 ± 10.90625 vs 24.7420 ± 21.79586) p = 0.388 comparison was not significant. The correlation between vitamin D and ferritin (p = 0.030) had a significant relationship. There was no significant correlation between Vitamin D and UAC (p = 0.730). The correlation between ferritin and UAC (p = 0.304) was not significant. Keywords: Vitamin D, Iron, Ferritin, UAC, CEDAbstract: Based on the prevalence of the Kediri Health Office in 2013 and 2014, pregnancy in CED in Kediri was 6.6% and 6.7%, which was an increase of 0.1% from the previous year. According to the prevalence of CED pregnancy in Badas Puskesmas in 2013 and 2014, it was 7.8% and 6.1%. Aimed at knowing the differences in vitamin D levels in normal pregnancy with second trimester CED pregnancy; know the difference between ferritin in normal pregnancy and second trimester CED pregnancy; know the correlation between vitamin D and ferritin in normal pregnancy and second trimester CED pregnancy; know the correlation between vitamin D and UAC in normal pregnancy and second trimester CED pregnancy. This study used an analytical test (case-control) with randomization of pregnant and pregnant CED patients in the Sukomanunggal district. The results showed that the difference in Vitamin D (33.5380 ± 5.60498 vs 32.4300 ± 4.40708) p = 0.166, the comparison was not significant. The difference in ferritin (17.4080 ± 10.90625 vs 24.7420 ± 21.79586) p = 0.388 comparison was not significant. The correlation between vitamin D and ferritin (p = 0.030) had a significant relationship. There was no significant correlation between Vitamin D and UAC (p = 0.730). The correlation between ferritin and UAC (p = 0.304) was not significant. Keywords: Vitamin D, Iron, Ferritin, UAC, CED

Erythrocyte Sedimentation Rate and Hemoglobin Levels in Pesticide Poisoning-Farmers Heru Cahjono; Salmon Charles P.T. Siahaan; Ferdinand Aprianto Tannus; Rizki Perdani; Eko Suhartono
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 11, No 2 (2022): SEPTEMBER 2022
Publisher : Universitas Wijaya Kusuma Surabaya

Pesticides are chemicals used to control insects, fungi, weeds, and others. Unrestrained use of pesticides leads to poisoning that has an impact on inflammation and anemia. To provide evidence for this notion, acetylcholinesterase enzyme levels, blood sedimentation rates, and blood hemoglobin levels of farmers exposed to pesticides have been studied. The study design was quantitative in a cross-sectional manner. The participants of the study were all members of the Kurnia Makmur farmer group in Landasan Ulin Utara District, Banjarbaru with a total sample of 60 people. An examination of acetylcholinesterase, erythrocyte sedimentation rate (ESR), and hemoglobin enzyme levels was carried out at the Banjar Regency Health Lab. The blood sample was withdrawn from the cubital vein. Spectrophotometry was used to determine acetylcholinesterase enzyme levels, while ESR was determined by the automatic method. Hemoglobin levels are measured by the cyanmethemoglobin method. T-tests were used to compare acetylcholinesterase, ESR, and hemoglobin levels in the normal group and the poisoning group. The study concluded that exposure to a pesticide in farmers' pesticide poisoning may cause inflammation characterized by an increase in ERS. However, there was no decrease in hemoglobin levels.

Juridical Analysis of Doctor's Criminal Liability in Medical Malpractice Cases Cahjono, Heru; Djatmika, Prija; Noerdajasakti, Setiawan
Pena Justisia: Media Komunikasi dan Kajian Hukum Vol. 22 No. 2 (2023): Pena Justisia
Publisher : Faculty of Law, Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Medical malpractice is one of the crucial issues in the world of law and health because it involves patient safety and the criminal responsibility of medical personnel. In Indonesia, the complexity of proving the elements of negligence, the limitations of evidence, as well as the inconsistency between legal norms and professional ethics are the main challenges in enforcing the criminal liability of doctors. This study aims to analyse the criminal liability of doctors in medical malpractice cases, particularly the obstacles in proving the criminal element and its implications for criminal law reform in Indonesia. The approach used is normative juridical, through literature study, legislation, and analysis of court decisions. The results showed that proving the element of guilt in medical malpractice relies heavily on expert testimony and the judgement of professional institutions such as MKDKI and MKEK, which often leads to differences in legal interpretation. The case study of Tangerang District Court Decision No. 1324/Pdt.G/2021/PN.Tng highlights the weak integration between professional ethical mechanisms and the national criminal system. This research has implications for the need for regulatory reform through the establishment of a lex specialis regarding the criminal liability of medical personnel, as well as strengthening the application of restorative justice in medical dispute resolution. The originality of this research lies in the focus of juridical analysis on the obstacles to proving criminal elements and comparative application of law in the context of the Indonesian legal system, which so far has not been the main focus in the health law literature.

Co-Authors Anak Agung Gde Budhiarta Eko Suhartono Ferdinand A Tannus Ferdinand Aprianto Tannus Helen Octavia Hendera Henderi Irwin Priyatna Kusumah Nimas Pristiwanto D S Prija Djatmika, Prija Rizki Perdani Salmon Charles P.T. Siahaan Salmon Charles Pardomuan Tua Siahaan Setiawan Noerdajasakti, Setiawan

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