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All Journal Manajer Pendidikan: Jurnal Ilmiah Manajemen Pendidikan Program Pascasarjana Indian Journal of Forensic Medicine & Toxicology
Ahmad Basori
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The Role of Cdk5 and TRPV1 in Meloxicam Resistance Signal Transduction in Rat Experiencing Chronic Pain Mohammad F. Qorib; Reny I’tishom; Sri A. Sudjarwo; Ahmad Basori
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15884

Abstract

Chronic pain is a common case and become a serious problem. Chronic pain management are inconclusive.One of the common treatment option is NSAID. Treatment Failed are around 34-79% of total case. Thesetreatment failed suspected as NSAID resistance. Treatment failed can be caused by a some molecule thatmake NSAID loss of efficacy. Cdk5 is one of the molecule that active in chronic pain condition. Cdk5 canincrease transmembrane insertion and activate TRPV1. The aim of this research is analyzed the role of cdk5and TRPV1 in NSAID resistance of chronic pain rat. This research used 42 rats as a subject and dividedinto 6 groups with random allocation method and factorial design. Meloxicam treatment was given orallyevery day for 7 days after rats have a chronic pain (28 days). Chronic pain induction used a CFA injection.Results : cdk5 and TRPV1 expression at the dorsal root ganglia of chronic pain groups are increase, nosignificant different of pain threshold and inflammation sign between treatment and no treatment groupsafter chronic pain occurred. Conclusion : chronic pain can induce cdk5 and TRPV1 expression, and inducedby meloxicam treatment. Cdk5 and TRPV1 have a positive correlation with meloxicam resistance.
PENINGKATAN KEMAMPUAN GURU DALAM MENERAPKAN TEORI BELAJAR KONSTRUKTIVISME MELALUI SUPERVISI AKADEMIK PENDEKATAN DIRECT INSTRUCTION Ahmad Basori
Manajer Pendididikan Vol 10, No 2 (2016)
Publisher : UNIVERSITAS BENGKULU

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (78.834 KB) | DOI: 10.33369/mapen.v10i2.1243

Abstract

The type of this research is to improve of teacher’s ability in implementing constructivism of learning theory. The method used through academic supervision approach direct instruction which held by four step, that is: review, presentation, practice guided and selfsupporting practice. This research was held in SMKN 2 Bengkulu City. The result of data analysis is the average of teacher’s ability in cycle I: test result is 72,04; writing lesson plan is 74,89 and implementing contructivism learning is 70,36. While the analysis result in cycle II: test result is 87,78, writing lesson plan is 89,11 and implementing constructivism learning is 86,66. The average score of teacher’s ability increase from cycle I to cycle II.Keywords: constructivism, learning theory, academic supervision, direct instruction
Co-Authors I'tishom, Reny Mohammad F. Qorib Sri A. Sudjarwo