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All Journal Bulletin of Electrical Engineering and Informatics Indonesian Journal of Electrical Engineering and Computer Science
Mohd Ridzuan Ahmad
Universiti Teknologi Malaysia
Electrical & Electronics Engineering

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Dielectrophoresis-based microfluidic device for separation of potential cancer cells Nur Fatien Najwa Mohamad Narji; Mohd Ridzuan Ahmad
Bulletin of Electrical Engineering and Informatics Vol 9, No 6: December 2020
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/eei.v9i6.2224

Abstract

Cancer is a leading cause of death that adversely affects all ages and genders around the world. There is a range of approaches such as CT scanning and mammography to diagnose cancer. Although the current method has many benefits, most of it share similar drawbacks as the result of detection takes long time and can lead to over diagnosis. Dielectrophoresis (DEP) is a method that can be used to obtain the cell electrical properties such as capacitance, conductivity, and permittivity. A device was designed in this study using a pair of electrodes and main channel with two inlets and two outlets. COMSOL software is adopted to analyze channel particle flow. Results show the configuration of microfluidic device and its dimensions. For potential application, DEP may be used as a non-invasive technique to distinguish normal cell from cancerous cell, which can lead to early detection as it offers a real-time warning. The simulations reveal that the electrodes captured the particles successfully and sorted them within specific time. The chance of cell capture and the ability of the electrodes to sort the cells is around 80%. In addition, an ideal design of the microfluidic chip was established, incorporating the cell and dielectric properties.
Tapered Microchannel for Multi-particles Passive Separation Based on Hydrodynamic Resistance Ida Laila Ahmad; Mohd Ridzuan Ahmad
Indonesian Journal of Electrical Engineering and Computer Science Vol 5, No 3: March 2017
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijeecs.v5.i3.pp628-635

Abstract

Researches on separation of multi-particles utilizing microfluidic have been flourishing in recent years with the aid from advancements in microfabrication design and technology. Generally, separation is beneficial for biomedical application especially involving heterogeneous samples. Due to inherent problems of samples isolation, a simple and efficient separation device is required. Here, we present a passive tapered microchannel for multi-particles separation using hydrodynamic principle. Our emphasis is on the effect of hydrodynamic resistance coupled with tapered microchannel design. In the experiment, successful multi-particles samples separation was observed. The results were further analyzed and were in agreement with the proposed concept. This method opens the route toward robust, low-cost and high-throughput, thus it may holds potential to be integrated as one functional module in micro total analysis system.
Co-Authors Ida Laila Ahmad Nur Fatien Najwa Mohamad Narji