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All Journal Science and Technology Indonesia Jurnal Penelitian Sains INDRA: Jurnal Pengabdian kepada Masyarakat

Rennie Puspa Novita

Unknown Affiliation

Author-ID : 2484694

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics

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Furosemide self nano emulsifying drug delivery system (SNEDDS) formulation comprising of capryol-90, polysorbate-80, and peg-400 with simplex-lattice-design Najma Annuria Fithri; Mardiyanto Mardiyanto; Rennie Puspa Novita; Vicky Andrean
Science and Technology Indonesia Vol. 2 No. 4 (2017): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Preparation of SNEDDS aims to improve solubility and absorption of furosemide in the body to reduce the dosage and minimize the side effects of drugs. Ternary diagram constructed from composition mixture produced nanoemulsion in the range of 20-40% of capryol-90, 20-40% polysorbate-80 and 40-60% PEG-400. Formulations of SNEDDS using Design-Expert®10 with simplex-lattice-design method in the study was aimed to investigate the effect of SNEDDS each component's proportions towards test responses. Emulsification time, drug content and viscosity were best demonstrated by run-7 with consecutive values of 131.68±2.14 seconds, 99.89±2.68% and 0.87±0.0043 mm2/s. The optimum formula was obtained through entering test response parameter data of all thirteen formula. Drug content and emulsification time was 107.0 ± 1.44% and 155.59±1.56 seconds with viscosity value 0.91±0.00 mm2/s. From the physical stability studies, SNEDDS formulas were stable and did not show phase separation when exposed to temparature stress testing.

Hepatoprotective effect of ethanol extract of matoa leaves (Pometia pinnata) against paracetamol-induced liver disease in rats Yosua Maranatha Sihotang; Eka Windiasfira; Hendro David Ginola Barus; Herlina Herlina; Rennie Puspa Novita
Science and Technology Indonesia Vol. 2 No. 4 (2017): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

The hepatoprotective effects of matoa leaves were evaluated by paracetamol-induced injury in rat’s hepatocytes. The ethanolic extract of matoa leaves (EEML) at doses of 200, 300, 500 mg/kg, po and silymarin at dose of 100 mg/kg, po were given for seven days. Silymarin was given as the reference drug. Hepatoprotective effect was studied by measuring the level of AST, ALT, ALP and total protein in serum. In vivo, oral treatment with EEML at dose of 500 mg/kg significantly reduced AST, ALT, ALP in serum whereas total protein was not significantly reduce in each groups. These results indicate that the hepatoprotective action of EEML is likely related to its potent antioxidative activity. Neutralizing reactive oxygen species enhancing the activity of original natural hepatic-antioxidant enzymes may be the main mechanisms of EEML against paracetamol-induced injury. Keywords: Matoa Leaves (Pometia pinnata), Paracetamol, Silymarin, Hepatoprotection

Co-Authors Annisa Amriani S Dapid Caniago Eka Windiasfira Fitrya Fitrya Hendro David Ginola Barus Herlina . Indah Solihah Mardiyanto Mardiyanto Najma Annuria Fithri Riana Sari Puspita Rasyid Vicky Andrean Yosua Maranatha Sihotang

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Journal : Science and Technology Indonesia