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All Journal EKSAKTA: Journal of Sciences and Data Analysis Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Pharmaciana: Jurnal Kefarmasian Universa Medicina Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Healthy-Mu Journal Refleksi Pembelajaran Inovatif JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Zainuri Sabta Nugraha
Departemen Anatomi Fakultas Kedokteran Universitas Islam Indonesia
Humanities Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Journal : JKKI : Jurnal Kedokteran dan Kesehatan Indonesia

 1 
PENGARUH MONOSODIUM GLUTAMAT TERHADAP TAMPILAN BELAJAR KONDISI OPERAN TIKUS PUTIH (Rattus norvegicus) GALUR WISTAR Kinasih D S; Zainuri Sabta Nugraha
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 5, No 2, (2013)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

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Abstract

Latar BelakangSampai saat ini masyarakat masih menggunakan zat aditif dalam mengkonsumsi makanan sehari-hari seperti Monosodium Glutamat (MSG). Efek MSG terhadap kualitas belajar masih diperdebatkan. Beberapa penelitian menyatakan bahwa MSG dapat menurunkan kualitas belajar, namun beberapa penelitian lain tidak memberikan efek kualitas belajar.TujuanUntuk mengetahui bagaimana pengaruh MSG terhadap tampilan belajar tikus putih (Rattus norvegicus) galur Wistar.MetodePenelitian ini merupakan penelitian eksperimental sederhana dengan rancangan pretestposttest controlled group design. Tikus putih sebanyak 18 ekor jantan dan betina dibagi menjadi 3 kelompok masing-masing 6 ekor sebagai kontrol dan perlakuan dengan diberikan MSG 120 mg/hari dan 240 mglhari peroral. Masing-masing kelompok diuji bela jar menggunakan skinner box selama 10 menit sebelum dan 4-5 jam setelah pemberian MSG yang kemudian dihitung jumlah reward dan punishment yang didapatkan selama 12 hari pengujian. Analisis menggunakan uji Oneway AN OVA, dan paired t test.HasilRerata reward pada kelompok kontrol, kelompok perlakuan A dan kelompok perlakuan B berturut-turut adalah 0,21; 0,12; 0,18 (p=0,629). Sedangkan rerata punishment bertututturut0,16; 0,15; 0,32 (p=0,169). Berdasarkan hasil penghitungan paired t-test untuk reward dan punishment pada kelompok A sebelum dan sesudah pemberian MSG nilai p berturut-turut 0,585 dan 0,006 sedangkan nilai signifikan untuk reward dan punishment pada kelompok B sebelum dan sesudah pemberian MSG adalah 0,208 dan 0,489.KesimpulanPenelitian ini membuktikan bahwa MSG dengan dosis 120mg/kgBB/hari dan 240mg/kgBB/hari yang diberikan selama 12 hari tidak berpengaruh terhadap tampilan belajar tikus putih (Rattus norvegicus) galur Wistar.
PENGUJIAN TERHADAP KADAR GAS FORMALIN DI RUANG PRAKTIKUM LABORATORIUM ANATOMI FAKULTAS KEDOKTERAN UNIVERSITAS ISLAM INDONESIA (UII) (Studi level Toksisitas Dibandingkan Dengan Standar Nilai Ambang Batas) Raden Edi Fitriyanto; Zainuri Sabta Nugraha
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 1, No 3, (2009)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

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Abstract

Formaline solvent is widely used in life, example as a preservative cadaver in anatomy laboratory. Forma line solvent can evaporate easily, in the form of gas it should be react with mucous layer quickly, especially at respiratory tract. In human body, it is oxidated become formic acid, especially in the cells of liver and red blood. In many earlier researches, the short-term exposure caused irritation to the local mucous surface of eyes, nose and up respiratory tract. However, the long term exposure caused tumor growth in the rat nose, pulmonary t issue damage and asthma reactions in sensitive individuals. The aim of the study is to measure forma line gas concentration and comparing the result with Thresold Limit Value (TLV) that safety for health. The research is nonexsperimental study with associative analysis. The research objects were practice space, storage cadaver space and lobby of Anatomy Laboratory. The research subjects were divided into 3 phases of measurement, phase I is measurement in the athmosphere (control), phase II is measurement in practice space laboratory during activities and phase Ill is measurement in practice space laboratory with no activities. Formaline gas concentration in practice space Anatomy Laboratory is under the TLV (TLV: 0.3 ppm) with no activities. Duringactivities, it is over the TLV: in preparation space 0,99569 ppm and practise space 0,37804 ppm. Formaline gas concentration in practice space during activities is over the TLV. It is a risk to cause some health disorders, especially to user and staff of the laboratory. It need good planning of practise programs and design of anatomy laboratory based on safety.
PENGARUH PEMBERIAN PROPOLIS TERHADAP EKSPRESI BDNF DI HIPPOCAMPUS TIKUS YANG DIINDUKSI STRES Kuswati Kuswati; Zainuri Sabta Nugraha; Ety Sari Handayani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 3, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss3.art8

Abstract

Background: Brain-derived neurotrophic factor (BDNF) is a neurotrophin secreted by dendrite, which plays a role in differentiation, maturation, neuroplasticity, learning, and memory, which the expression decreases under stress conditions. Propolis contains chrysin which has antioxidant and neuroprotectant effects.Objective: This study aimed to examine the effect of propolis on BDNF expression in the hippocampus of stress-induced rats.Methods: Experimental study using posttest only control group design. The subjects were 25 male Spraque-Dawley rats (Rattus norvegicus), four months old, weighing 200-300 grams. Rats were randomly divided into five groups: group N, did not receive any treatment; group K, received stress treatment; groups P1, P2, and P3, received stress treatment and followed by administered propolis at doses of 100, 150, and 200 mg/kg/day. Social isolation stress was carried out by putting one rat in one cage. Oral propolis administration used oral gavage. In the end, the rats were terminated and brain tissue was collected. Immunohistochemical staining using anti-BDNF antibodies was performed to make histological slides. Observations were made with a light microscope with 1000x magnification in the CA1 area of the hippocampus.Results: There is a significant difference in BDNF expression in the CA1 area of the hippocampus in all groups (p=0.000). The highest BDNF expression was in the P3 group and the lowest in group K.Conclusion: There is an effect of propolis on BDNF expression in the hippocampus of the stress-induced rat. Propolis dose of 100 mg/kgBW/day has increased BDNF expression.
Co-Authors . Harijadi Arie Nugroho Chandra Muhammad Rauf Ety Sari Handayani Ety Sri Handayani Febiawan Ismunandar Fitriyanto, Raden Edi Fuad Khadafianto Ika Fidianingsih Kinasih D S Kuswati Kuswati Kuswati, Kuswati MARIA BINTANG Muchamad Marwan Muhammad Yusuf Hisyam Nurul Hidayah Prilly i Raleka Pahlevawati Sahdella Sahdella Soedjono Aswin Untung Widodo Wimpy Wimpy Yusa Muhammad Thoriq Yusi Maulina