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The correlation between interleukin-4 (IL-4) and programmed cell death-ligand 2 (PD-L2) expression with clinicopathological characteristics on prostate cancer Prakoso, Ragil Unggul; Danarto, Raden; Soerohardjo, Indrawarman; Dany, Yurisal Akhmad; Dwianingsih, Ery Kus
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 01 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i01.12438

Prostate cancer (PCa) is the most frequent cancer diagnosed worldwide and the second most common malignancy in men. IL-4 is one of cytokines related to the inflammation process. An increase level of IL-4 in patients with PCa might be related to progression to castrate-resistance prostate cancer. Programmedcell death-ligand 2 (PD-L2) plays an important role in the anti-tumor immune system, however the exact mechanism is not fully understood. This study aimed to investigate the correlation between IL-4 and PD-L2 expression with the clinicopathological characteristic of PCa. The IL-4 and PD-L2 examinations wereperformed using quantitative real-time polymerase chain reaction (qRT-PCR) while clinicopathological characteristics were described by the Gleason score and International Society of Urological Pathology (ISUP) grade. Data collected were then analyzed using Pearson and Spearman test. In total, 20 patients withPCa tissue were collected between 2015 and 2020. The mean level of IL-4 and PDL2 were higher in metastatic PCa/M-PCa (105.64 and 665.42 ng/mL) compared to non-metastatic PCa/NM-PCa (41.62 and 215.06 ng/mL). A significant difference with medium correlation between IL-4 and PD-L2 with Gleason score and ISUPgrade was observed on all samples (p = 0.035 and 0.045; r = 0.454 and 0.473). However, no significant difference with weak correlation was observed on each group (p = 0.136 and 0.858; r = 0.065 and 0.506). Interestingly, there was a significant difference with very strong correlation observed between IL-4 andPD-L2, both on all samples (p = 0.001; r = 0.955) and on each group (p = 0.001 and 0.001; r = 0.917 and 0.955). In conclusion, there is a correlation between IL-4 and PD-L2 with the clinicopathological characteristics of PCa.

Diagnostic performance of sex hormone binding globulin (SHBG) expression in predicting prostate cancer (PCa) Lubis, Anggiat Pratama; Danarto, H R; Indrawarman; Yurisal Akhmad Dany; Ery Kus Dwianingsih
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 2 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i2.13906

Globally, 1.3 million new cases of prostate cancer (PCa) and 359,000 deaths were reported in 2018. Due to rapid population growth and increasing rates of aging worldwide, the PCa has become the 5th leading cause of death in men. Sex hormone binding globulin (SHBG) presents in both men and women and its expression is often associated with the development of PCa and breast cancers. This study was conducted to assess the diagnostic performance of SHBG expression in predicting PCa. A total of 31 patients with PCa and 14 patients with BPH as a control were involved in this study. The SHBG expression of formalin-fixed paraffin-embedded (FFPE) prostate tissue was examined by the quantitative reverse transcriptase polymerase chain reaction (RT-PCR). Receiver operator characteristic (ROC) curves were produced and the area under the curve (AUC) was calculated to evaluate the diagnostic performance of the SHBG expression in predicting the PCa. The AUC of SHBG expression was 0.868 (95% CI 0.764-0.971; p<0.001) which indicated good diagnostic performance. The cutoff value was 6.731 which corresponded to 80% accuracy, 71% sensitivity, and 100% specificity. In conclusion, SHBG expression in prostate cancer tissues could be a molecular marker in PCa diagnosis. ABSTRACT Secara global terdapat 1,3 juta kasus baru kanker prostat (prostate cancer/PCa) dan 359.000 kematian dilaporkan pada tahun 2018. Karena pertumbuhan populasi yang cepat dan meningkatnya angka usia lanjut di seluruh dunia, PCa telah menjadi penyebab kematian utama ke-5 pada pria. Sex hormone binding globulin (SHBG) terdapat pada pria dan wanita dan ekspresinya sering dikaitkan dengan perkembangan PCa dan kanker payudara. Penelitian ini dilakukan untuk menilai potensi SHBG sebagai penanda molekuler dalam diagnosis PCa. Sebanyak 31 pasien PCa dan 14 pasien BPH sebagai kontrol dilibatkan dalam penelitian ini. Ekspresi SHBG dari jaringan prostat formalin-fixed paraffin-embedded (FFPE) diperiksa dengan the quantitative reverse transcriptase polymerase chain reaction (RT-PCR). Receiver operator characteristic (ROC) dihasilkan dan the area under the curve (AUC) dihitung untuk mengevaluasi kinerja diskriminatif ekspresi SHBG dalam diagnosis PCa. AUC ekspresi SHBG adalah 0,868 (95% CI 0,764-0,971; p<0,001) yang menunjukkan kinerja diskriminatif yang baik. Nilai cutoff adalah 6,731 yang berhubungan dengan akurasi 80%, sensitivitas 71% dan spesifisitas 100%. Kesimpulannya, ekspresi SHBG pada jaringan kanker prostat dapat menjadi penanda molekuler dalam diagnosis PCa

Research Trend On Healthcare (Hospital Financial) Failure And Activity-Based Costing Methods: A Bibliometric Analysis Dany, Yurisal Akhmad; Pribadi, Firman
Jurnal Riset Kesehatan Vol 13, No 2 (2024): NOVEMBER 2024
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jrk.v13i2.12206

Hospital financial failure means bankrupt in economic point-of-view. While from the patient care perspective, it can compromise healthcare delivery and deliver possible harm due to substandard services. Leveraging digitalization and information technology can significantly enhance financial management, improve efficiency, and ultimately support sustainable healthcare services. This bibliometric analysis through Scopus database. Retrieved articles were examined based on annual publication numbers, contributing countries, subject areas, authors, and cited documents. Visual analysis was done using VOSviewer to provided insights into word co-occurrence in clusters and R Studio's Bibliometrix package was employed to identify the most contributing countries and the most cited publications. The analysis on total 429 articles revealed that healthcare and activity-based costing is an emerging trend, with a growing number of publications each year. The United States emerged as the leading country in this research area, though other nations also contributed significantly. Medicine was identified as the most common subject area. VOSviewer analysis identified seven clusters related to the topic. Activity-based costing has evolved to accurately assess product costs in changing business landscapes, particularly in healthcare, where it helps optimize profits. The findings indicate a growing awareness of the importance of financial management in sustaining healthcare services globally. However, the study's reliance on a single database and lack of a comprehensive systematic review limit its scope, potentially excluding relevant research from other sources.

Research Trend On Healthcare (Hospital Financial) Failure And Activity-Based Costing Methods: A Bibliometric Analysis Dany, Yurisal Akhmad; Pribadi, Firman
Jurnal Riset Kesehatan Vol 13 No 2 (2024): NOVEMBER 2024
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jrk.v13i2.12206

Hospital financial failure means bankrupt in economic point-of-view. While from the patient care perspective, it can compromise healthcare delivery and deliver possible harm due to substandard services. Leveraging digitalization and information technology can significantly enhance financial management, improve efficiency, and ultimately support sustainable healthcare services. This bibliometric analysis through Scopus database. Retrieved articles were examined based on annual publication numbers, contributing countries, subject areas, authors, and cited documents. Visual analysis was done using VOSviewer to provided insights into word co-occurrence in clusters and R Studio's Bibliometrix package was employed to identify the most contributing countries and the most cited publications. The analysis on total 429 articles revealed that healthcare and activity-based costing is an emerging trend, with a growing number of publications each year. The United States emerged as the leading country in this research area, though other nations also contributed significantly. Medicine was identified as the most common subject area. VOSviewer analysis identified seven clusters related to the topic. Activity-based costing has evolved to accurately assess product costs in changing business landscapes, particularly in healthcare, where it helps optimize profits. The findings indicate a growing awareness of the importance of financial management in sustaining healthcare services globally. However, the study's reliance on a single database and lack of a comprehensive systematic review limit its scope, potentially excluding relevant research from other sources.

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