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All Journal INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Majalah Kedokteran Andalas
Sajid Darmadipura
Unknown Affiliation
Health Professions Medicine & Pharmacology Public Health

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LIPID PEROXIDATION AFTER INTRACORTICAL INJECTION OF FERRIC CHLORIDE INCREASES THE INCIDENCE OF SEIZURES IN YOUNG RATS Golden, Nyoman; Agus Bagiada, Nyoman; Darmadipura, Sajid
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 3, No. 2 Juli 2009
Publisher : Udayana University

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Abstract

Clinical studies have shown that the incidence of early posttraumatic seizures ishigher in children than in adults and it has been proposed that iron-induced lipidperoxidation has an important role in the development of epileptogenic foci. In this study,we examined some of the hypothesized reasons for the difference in the incidence ofearly posttraumatic seizures between young and adult rats. Twelve young and twelveadult rats were randomized into 4 groups. Group 1 and 2 were control groups, eachcomprising of 6 young rats and 6 adult rats respectively and were given intracorticalinjections of normal saline. Group 3 and 4 were injury groups, again comprising 6 youngrats and 6 adult rats respectively and were given intracortical injections of FeCl3. All ratswere observed for 6 hours post injection for the occurrence of seizures and were thenkilled. The injected hemispheres were extirpated and tested for malondialdehyde (MDA)level and superoxide dismutase (SOD) activity as indices of oxidative damage. Resultsshowed that seizures were observed only in Group 3. Increased MDA level and decreasedSOD activity were observed in Group 3 (ANOVA, p<0.001). Increased MDA levels anddecreased SOD activity were significantly higher in rats with seizures (Group 3) than inthose without seizures (independent t-test, p<0.001). We conclude was that differentlevels of lipid peroxidation induced by intracortical ferric chloride injection may accountfor the different seizure incidence between young and adult rats
MEDICAL ETHICS, LOCAL WISDOM AND PROFESSIONALISM Sajid DarmadiPura
Majalah Kedokteran Andalas Vol 37 (2014): Supplement 1 | Published in March 2014
Publisher : Faculty of Medicine, Universitas Andalas

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AbstractRecengy the problem of profession, professional, professionalism, and ethics in medicinehave been attracting much the public, the media, the professionals, and even also the medicalpractitioners.This may be stimulated by several cases involving medical professionals exposedby the press, originaiing from the decreasing comprehension on the above named terms' Theline differentiating profession from business is too becoming vague. Professionalism that shouldcontain also high ethical moral standards and humanitarian values beside the knowledge andskill is decreasing in comprehension among the medical practitioner and other professionals ingeneral. A clear normative definition of each of those terms is needed. As lndonesian physicians,we should refer and apply the basic principles stated in Pancasila, i.e' the philosophical moralbasis of the lndonesia foundation in providing medical and health service. Further our reflectionsgo on to whether the principles of Pancasila can replace the ethical principles of Bioethics, thewestern concept. Accepting the western completely would likely mean accepting the culturalimperialism, while replacing the western values or principles totally is unnecessary consideringthat many of the western conform our local wisdom'Keywords: Profession, professionalism, medical ethics, Pancasila, local wisdom'transculturalism and value recipi"ocity'
Co-Authors Nyoman Agus Bagiada Nyoman Golden