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Anna Martiana
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Medicine & Pharmacology

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Inhibitory Effect of Neem Leaves on Glucose Transport Lia Safitrie Johansyah; Vycke Yunivita; Anna Martiana; Augusta Y. L. Arifin
Althea Medical Journal Vol 5, No 4 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (494.386 KB) | DOI: 10.15850/amj.v5n4.501

Abstract

Background: Neem leaf is known as a diabetic herbal treatment in India, however, its antihyperglycemic effect and the mechanism is still unknown. Quercetin is proven to inhibit glucose transporter in the small intestine, and this active substance is present in Neem leaves. The study was conducted to explore the inhibitory effect of Neem leaves infusion on glucose transport and whether the effect was reversible or irreversible.Methods: This study was conducted in the Biochemistry Laboratory Faculty of Medicine Universitas Padjadjaran in the period of October to November 2012 by using in situ perfusion method. Five male Wistar rats were given three treatments; glucose as initial control, glucose with Neem infusion, and glucose again as last control. The samples of perfusion solution were taken for every treatment and were measured using spectrophotometry method.Results: There was a reduction in glucose absorption (15.9%) between the first (47.28+17.57 mg/dL) and the second treatment (39.75+14.85 mg/dL). The transported glucose level in the third treatment was further reduced after the first treatment (37.15+13.15 mg/dL).Conclusions: Neem leaves infusion has inhibitory effect on glucose transport that irreversibly reduced further. Further study is needed with a larger sample size to confirm this phenomenon. 
Effect of Spondias dulcis Leaves Infusion on Glucose Transport Rate through Rat Intestine Epithelium Cell Membrane Krisna Destia; Anna Martiana; Sylvia Rachmayati
Althea Medical Journal Vol 3, No 4 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (194.92 KB)

Abstract

Background: Nowadays, people consume herbal remedies made from plants which are believed to be able to relieve certain symptoms and restore normal metabolic functions. Golden apple (Spondias dulcis) leaf has the potential to lower blood glucose. The purpose of this experiment was to observe the anti–hyperglycemic effect of S. dulcisleaves infusion on glucose transport rate through intestinal mucosal membrane of Wistar rats.Methods: An experimental study was conducted from October 2013 to November 2014. Nine male Wistar rats were selected aged 12–16 weeks, weighted 250–400 grams, healthy, actively moving, and had never been used in experiments. The rats were anesthetized, cut open and given three kinds of treatments: three kinds of glucose solutions were flowed through the intestinal tract using in situ perfusion method. Samples obtained from the rat’s intestine were measured with a spectrophotometer to obtain glucose rate transported through intestinal membrane from every treatment. The results of condition 1 and 2, and condition 1 and 3 were then compared.Results: The means of glucose transported through rat intestines epithelium cell membrane were 6.43 mg/dl, 9.40 mg/dl and 9.81 mg/dl. Statistic test result showed there was no significant difference on the glucose transported in every treatment.Conclusions: Glucose absorption rate in rat intestine doesnot decrease after they are given S. dulcis leaves infusion. Therefore, this experiment concludes that S. dulcis leaves do not affect the glucose transport rate in rat intestines epithelium cell membrane. [AMJ.2016;3(4):562–5] DOI: 10.15850/amj.v3n4.939
Co-Authors Augusta Y. L. Arifin Krisna Destia Lia Safitrie Johansyah Sylvia Rachmayati Vycke Yunivita