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All Journal International Journal of Integrated Health Sciences Althea Medical Journal Berkala Ilmu Kesehatan Kulit dan Kelamin
Jono Hadi Agusni
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Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Association between Patient’s Basic Characteristic and Clark Level in Cutaneous Malignant Melanoma Egie Rahmalaelani; Hermin Aminah Usman; Jono Hadi Agusni
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Malignant melanoma is  a cancer that begins in the melanocytes. Melanoma is commonly happened on older people, male and located on sun exposure body area, such as face, neck and lower limb. Melanoma cases occur less than 5% of skin cancer but cause a majority of skin cancer deaths because melanoma has an aggressive behavior. Age, sex, location of lesion, and type of melanoma influences the melanoma invasion. The cutaneous melanoma invasion could be assessed with the Clark level. This study is aimed to determine the association between patient’s basic characteristic and Clark level in cutaneous malignant melanoma.Methods: This study used cross sectional analytic design. The medical records and histopathology slide from the Department of Anatomic Pathology Dr. Hasan Sadikin General Hospital from 2008−2012 took as a sample. Forty one data were meet the inclusion criteria.  Furthermore, those data were analyzed using chi-square test.Result: Overall, patient’s characteristic in this study, commonly occurred on female (66%), 50−59 years group age (35%), non-cephalic/acral location (71%), and the level V in Clark level (73%). Location of lesion showed an association with Clark level (p=0.023), whereas, age and sex was not significant (p=0.679 and p=0.389).Conclusions: There is an association between location of lesion and Clark level [AMJ.2017;4(1):25–9]DOI: 10.15850/amj.v4n1.1015 
Comparison of the Effectiveness of Phosphorus 32 Application and 10 Mg/Cc Triamcinolone Acetonide Intralesional Injection on Keloid Hani Indrayati; Jono Hadi Agusni; Asmaja Soedarwoto; Achmad Hussein S. Kartamihardja
International Journal of Integrated Health Sciences Vol 4, No 1 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Objective: To analyze the effectiveness of phosphorus 32 (32P) application compared to 10 mg/cc triamcinolone acetonide (TA) intralesional injection in keloid.Methods: A single blind (evaluator blind) randomized clinical trial on 52 keloids was conducted during the period of May – August 2014 in Tumor and Skin Surgery Clinic, Department of Dermatovenereology and Department of Nuclear Medicine and Molecular Imaging, Dr. Hasan Sadikin General Hospital Bandung.Results: Lesions were divided into two groups with each group consisted of 26 lesions. Group A was treated with 32P application whereas group B was treated with 10 mg/cc TA intralesional injection. Flattening of the lesion of more than 50% was higher in the group treated with 32P application (76.9%) compared to the group that was treated with 10 mg/cc TA intralesional injection (57.7%) on the 8th week, but the difference was not statistically significant (p>0.05).Conclusions: Based on the statistical analysis, the application of 32P was as effective as the intralesional injection of 10 mg/cc TA for keloid lesions.Keywords: Flattening, keloid, phosphorus 32, triamcinolone acetonide DOI: 10.15850/ijihs.v4n1.683
Triamcinolone Acetonide and 5-Fluorouracil Intralesional Combination Injection in Keloid Treatment Jono Hadi Agusni; Eva Krishna Sutedja; Franky Chandra
International Journal of Integrated Health Sciences Vol 5, No 1 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Objective: To evaluate the effectiveness of steroid and 5-fluorouracil (5-FU) injection combination for keloid management.Methods: A 22-year-old female patient was presented with recurrent skin lesions. The skin lesions first appeared 10 years prior to consultation, had been surgically excised, and were given triamcinolone acetonide injection. However, no improvement was observed. A decision was made to use and evaluate treatment using an intralesional 4 mg (0.1 ml of 40 mg/ml) triamcinolone acetonide and 45 mg (0.9 ml of 50 mg/ml ) 5-FU injection combination for 5 weeks.Results: Clinical improvements were observed in the third week as the lesions softened and pruritic sensation dinimished. At the end of the fifth week, improvements in the form of keloid lesion flattening and size reduction were observed.Conclusions: Intralesional injection using a combination of triamcinolone acetonide and 5-fluorouracil is effective for keloid lesion treatment.Keywords: 5-fluorouracil, intralesional injection, keloid, triamcinolone acetonide DOI: 10.15850/ijihs.v5n1.959
The Correlation between Interleukin-10 Serum with Bacterial Index in Multidrug Therapy-treated Leprosy Patients Eva Krishna Sutedja; Jono Hadi Agusni; Hartati Purbo Dharmadji
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 1 (2016): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (403.285 KB) | DOI: 10.20473/bikk.V28.1.2016.16-22

Abstract

Background: Immune respons disturbance oftenly found in leprosy patient, mainly in various T cell subset and cytokine immune system arranger. Interleukin-10 produced by Th 2 cell, Th3 cell, monocyte, dendritic cell, eosinophil, mast cell, and keratinocyte. Interleukin 10 (IL-10) works in active macrophage to end the respons to microbe and restore the system to the resting state after the microbes are destroyed. Purpose: To analyze correlation between IL-10 level with Bacterial Index (BI)  in Multidrug Therapy (MDT)-treared leprosy patient. Methods: Cross sectional analytical observational study of 43 subjects, consisting of 38 males (88.4%) and 5 females (11.6%). The IL-10 examination used quantitative sandwich enzyme immunoassay, human IL-10 Quantikine® ELISA methods from R & D systems® Result: There was positive correlation between IL-10 and BI of MDT-treated leprosy patient (r = 0,504; p=0,001). Conclusion: The increasing of IL-0 correlated with high BI. Interleukin-10 level is higher in MB type than PB type of leprosy patients.Key words: Interleukin-10 (IL-10), bacterial index (BI).
Co-Authors Achmad Hussein S. Kartamihardja Asmaja Soedarwoto Egie Rahmalaelani Eva Krishna Sutedja Franky Chandra Hani Indrayati Hartati Purbo Dharmadji Hermin Aminah Usman