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All Journal Jurnal Ilmu dan Teknologi Kayu Tropis Wood Research Journal : Journal of Indonesian Wood Research Society Wood Research Journal : Journal of Indonesian Wood Research Society
Kuniyoshi Shimizu
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Agriculture, Biological Sciences & Forestry

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Anti-proliferative Activity of Some Oleanolic Acid Derivatives with Potent Topoisomerase Inhibitory Activity on B16 Melanoma Cells Ahmed Ashour; Ryuichiro Kondo; Kuniyoshi Shimizu
Wood Research Journal Vol 9, No 1 (2018): Wood Research Journal
Publisher : Masyarakat Peneliti Kayu Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51850/wrj.2018.9.1.26-28

Abstract

Our previous study included the semisynthetic reactions on oleanolic acid, a common wood-derived oleanane-type triterpene. Ten rationally designed derivatives of oleanolic acid were synthesized based on docking studies and tested for their topoisomerase I and IIα inhibitory activity. Semisynthetic reactions targeted C-3, C-12, C-13 and C-17. Some of these compounds act as dual inhibitors for both topoisomerase I and IIα giving new anticancer agents. The cytotoxic activity of these compounds on B16 melanoma cancer cells was evaluated. Results showed that most of these compounds have a higher cytotoxic activity on B16 melanoma cells.
Anti-proliferative Activity of Some Oleanolic Acid Derivatives with Potent Topoisomerase Inhibitory Activity on B16 Melanoma Cells Ahmed Ashour; Ryuichiro Kondo; Kuniyoshi Shimizu
Wood Research Journal Vol 9, No 1 (2018): Wood Research Journal
Publisher : Masyarakat Peneliti Kayu Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51850/wrj.2018.9.1.26-28

Abstract

Our previous study included the semisynthetic reactions on oleanolic acid, a common wood-derived oleanane-type triterpene. Ten rationally designed derivatives of oleanolic acid were synthesized based on docking studies and tested for their topoisomerase I and IIα inhibitory activity. Semisynthetic reactions targeted C-3, C-12, C-13 and C-17. Some of these compounds act as dual inhibitors for both topoisomerase I and IIα giving new anticancer agents. The cytotoxic activity of these compounds on B16 melanoma cancer cells was evaluated. Results showed that most of these compounds have a higher cytotoxic activity on B16 melanoma cells.
Artocarpin, A Promising Compound as Whitening Agent and Anti-skin Cancer Enos T Arung; Sipon Muladi; Edi Sukaton; Kuniyoshi Shimizu; Ryuichiro Kondo
Jurnal Ilmu dan Teknologi Kayu Tropis Vol 6, No 1 (2008): Jurnal Ilmu dan Teknologi Kayu Tropis
Publisher : Masyarakat Peneliti Kayu Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (202.281 KB) | DOI: 10.51850/jitkt.v6i1.256

Abstract

In our search for natural products from wood on cosmetics and drugs purposes and on the basis of melanin biosynthesis assay guided fractionation, artocarpin was isolated from wood of Nangka (Artocarpus heterophyllus). To evaluate the potency as a whitening agent of artocarpin and its anti-skin cancer (cytotoxicity effect), the MTT assay was used to evaluate its cytotoxicity on cells and melanin biosynthesis assays was performed to determine its whitening agents potency. The evaluation of cytotoxicity on B16 melanoma cells of Artocarpin resulted the IC50 was 10.3 µM and melanin biosynthesis assay with IC50 6.7 µM with out cytotoxicity. Based on the results, suggested that artocarpin have a potent to be developed as whitening agent and skin cancer drug.
Co-Authors Ahmed Ashour Edi Sukaton Enos T Arung Ryuichiro Kondo Sipon Muladi