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All Journal Medical Laboratory Technology Journal Jurnal Kedokteran Universitas Palangka Raya
Rima Agnes Widya Astuti
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Anemia dan Lama Konsumsi Obat Anti Tuberculosis Anny Thuraidah; Rima Agnes Widya Astuti; Dinna Rakhmina
Medical Laboratory Technology Journal Vol. 3 No. 2 (2017): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (841.815 KB) | DOI: 10.31964/mltj.v3i2.157

Abstract

Tuberculosis is an infectious disease due to Mycobacterium tuberculosis germ that can infect several organs, including the lungs, kidneys, and bones. The goal of treatment of tuberculosis is tuberculosis bacilli destroy quickly and prevent recurrence. First category treatment of tuberculosis is isoniazid, rifampin, streptomycin, ethambutol, and pyrazinamide. Although the most anti-tuberculosis drug is acceptable in therapy, but have potentially toxic effects hematologic reactions such as agranulocytosis, eosinophilia, thrombocytopenia, and anemia. This research aims to know the correlation between anti-tuberculosis drug consumption in pulmonary TB patients against anemia. Method of this research was Analytical Survey with a Cross-Sectional design. The average results of red blood cell count for 0 months 5,16 106/uL, 2 months 4,39 106/uL and 6 months 4,61 106/uL, haemoglobin levels for 0 month 15,17 g/dL, 2 months 12,73 g/dL and 6 months 13,28 g/dL as well as hematocrit value for 0 month 44,26 %, 2 months 38,24 % and 6 months 39,04 %. From Spearman statistics analytical was obtained significant of red blood cell count 0.004 < α (0.05), levels of hemoglobin 0.007 < α (0.05) and the value of hematocrit 0.015 < α (0.05), it was concluded there was correlation between long consumption of anti-tuberculosis drug with anemia and the value of the correlation coefficient count of red blood cells -0.531, levels of hemoglobin-0.479 as well as the value of hematocrit -0.440 means has the power correlations are medium. Further research is recommended to use different parameters such as the number of platelets, AST/ALT levels and should use the same patient sample or from 0 months up to 6 months
Efektivitas ekstrak buah senduduk (Melastoma malabathricum l.) sebagai pewarna apusan darah tepi Iqlila Romaidha; Mega Silvia Madani; Larantika Hidayati; Rima Agnes Widya Astuti
Jurnal Kedokteran Universitas Palangka Raya Vol 12 No 1 (2024): Jurnal Kedokteran Universitas Palangka Raya
Publisher : Fakultas Kedokteran, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/jkupr.v12i1.12879

Abstract

Blood comes from the Greek words hemato, hemo, and haima. Blood has an important role in human life. One of the examinations for diagnosing disease is a peripheral blood smear. The smear method is a microtechnical method used to make preparations. Guaranteeing the quality of the examination of blood smears is the quality of the coloring of peripheral blood smears. Giemsa dye is the most commonly used for peripheral blood smears. Giemsa contains chemicals including methylene blue, azur, and eosin. Methylene azur and eosin provide color in the cell nucleus, as does methylene blue, a cytoplasmic dye. Giemsa is not environmentally friendly and has quite high prices. This study aims to determine the effectiveness of senduduk fruit extract with concentrations of 20%, 40%, 60%, 80%, and 100% as an alternative to Giemsa staining in peripheral blood smears. The research method is descriptive-qualitative with a true experimental research design. The extract was made using the maceration extraction method, using a rotary evaporator as a means of concentrating the senduduk extract. In research that has been carried out at each concentration used, the morphology of erythrocytes is very clear. At a concentration of 100%, platelets are clearly visible. The single extract at concentrations of 40%, 60%, and 80% of the cytoplasm still appeared colored. Meanwhile, leukocyte granules were not stained at all concentrations. The most optimal coloring for senduduk fruit extract is coloring at a concentration of 80%, which is quite good at coloring red blood cells and platelets. A concentration of 100% has a clear morphology of blood cells and platelets that can be differentiated from the others
Co-Authors Anny Thuraidah Dinna Rakhmina Iqlila Romaidha Larantika Hidayati Mega Silvia Madani