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All Journal Jurnal Ilmu Kefarmasian Indonesia Jurnal Farmamedika (Pharmamedica Journal) Sciences of Pharmacy
Rika Sari Dewi
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Uji Efek Anti-inflamasi dan Analgesik Ekstrak Etanol 70% Kulit Batang Kayu Manis (Cinnamomum burmannii Blume.) Secara In Vivo Dewi, Rika Sari; Sandhiutami, Ni Made Dwi; Evangelia, Beatrix Melani; Bakhtiar, Muhammad Taher
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1374

Abstract

Cinnamon bark is known as a medicinal plant to has anti-inflammatory and analgesic effects in vitro. This activity is due to bark of cinnamon containing several compounds including cinnamaldehyde, cinnamic alcohol, cinnamic acid and coumarin. The aim of this study was to observe anti-inflammatory and analgesic effects in vivo. Anti-inflammatory test using Winter method and rats. Rats were divided into five groups negative control (aquadest), positive control (sodium diclofenac), and three extract groups with different doses (300, 400, and 500 mg/kg BW). In an analgesic test using the Siegmund method and mice. Mice were also divided into five groups negative control (aquadest), positive control (sodium diclofenac), and three extract groups with different doses (300, 400, 500 mg/kg BW). Based on a statistical test, 70% ethanol extract of cinnamon bark has anti-inflammatory and analgesic effects, also showed that there was a significant difference between the positive controls and the three extract doses. This shows that the anti-inflammatory and analgesic activity of diclofenac sodium is better than the ethanol extract of cinnamon bark in reducing the edema volume of rats and the amount of mice stretch. In conclusion,cinnamon bark showed no significant increment in high doses of anti-inflammatory and analgesic.
POTENSI EKSTRAK ETANOL 70% DAUN JAMBU BOL (SYZYGIUM MALACCENSE (L.) MERR. & L.M. PERRY) TERHADAP KADAR MALONDIALDEHID DAN AKTIVITAS ANTIOKSIDAN ENZIM SUPEROKSIDA DISMUTASE PADA MENCIT Dewi, Rika Sari; Dwi Sandhiutami , Ni Made; Tasya K. Siagian , Inneke
Jurnal Farmamedika (Pharmamedika Journal) Vol 10 No 2 (2025): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/ath.v10i2.353

Abstract

Daun Jambu bol (Syzygium malaccense (L.) Merr. & L.M.Perry) memiliki senyawa polifenol seperti flavonoid, asam fenolat dan tannin telah dianggap sebagai antioksidan. Penelitian ini bertujuan menguji aktivitas antioksidan ekstrak etanol 70% daun jambu bol (Syzygium malaccense (L.) Merr. & L.M.Perry) berdasarkan parameter kadar malondialdehid (MDA) dan aktivitas superoksida dismutase (SOD). Mencit dibagi menjadi 6 kelompok yaitu: kelompok kontrol normal, kelompok kontrol negatif, kelompok kontrol positif diberikan vitamin C (2,6 mg/20gBB), dan 3 kelompok dosis ekstrak etanol 70% daun jambu bol (5; 10; 20 mg/20gBB). Pengukuran kadar MDA dilakukan dengan metode TBARs dan pengukuran aktivitas SOD dilakukan dengan metode Adrenochrome Assay. Hasil pengukuran kadar MDA pada kelompok normal, kelompok kontrol negatif, kelompok kontrol positif, kelompok dosis 5 mg/20gBB; 10 mg/20gBB; 20 mg/20gBB secara berturut-turut adalah 2,4814 nmol/mL; 5,0557 nmol/mL; 3,0153 nmol/mL; 4,7122 nmol/mL; 4,1289 nmol/mL; 3,5013 nmol/mL sedangkan untuk hasil pengukuran aktivitas SOD pada hati mencit adalah 124,9967 U/mL; 60,34 U/mL; 188,76 U/mL; 129,31 U/mL; 148,85 U/mL; 168,9667 U/mL. Kesimpulan hasil yang didapatkan adalah ekstrak etanol 70% daun jambu bol (Syzygium malaccense (L.) Merr. & L.M.Perry) memiliki potensi antioksidan dengan menurunkan kadar MDA dan meningkatkan aktivitas SOD.
Potential of Ciplukan Leaf (Physalis Angulate L.) Infusion as A Bronchodilator in Pulmonary Histopathology of Sprague Dawley White Rats Dewi, Rika Sari; Saragih, Kristin Grave Gracia
Sciences of Pharmacy Volume 3 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0301216

Abstract

Ciplukan leaves contain alkaloid compounds and exhibit pharmacological activity as bronchodilators. Bronchodilators are utilized in chronic inflammatory respiratory conditions such as asthma, involving various cell types such as mast cells, eosinophils, and epithelial cells. The objective of this study was to evaluate the effectiveness of administering Ciplukan leaf infusion as a bronchodilator. A total of 24 Sprague Dawley rats were divided into 6 groups: normal control (K1), negative control (K2), positive control (K3), 200 mg/kg BW dose (K4), 400 mg/kg BW dose (K5), and 800 mg/kg BW dose (K6). On days 1 and 8, rats were sensitized with 0.35 mg OVA + 1 mg AlOH3 in 0.9% NaCl (i.p). On days 15, 17, and 19, rats were re-sensitized with inhaled OVA. From day 20 to 28, K1 and K2 received no treatment, K3 received 2 mL/day of salbutamol, and the dose groups were administered 2 mL/day of Ciplukan leaf infusion; all treatments were carried out simultaneously. On day 29, rats were dissected, and their lung organs were collected for histopathological preparation. Research findings revealed a reduction in bronchiolar epithelial thickness across groups in the following order: 495.05; 584.95; 334.69; 421.70; 482.81; 484.95 µm. The sequential lung eosinophil counts were 19; 44; 37; 23; 17; and 27, and mast cell counts were 9; 22; 13; 15; 13; and 7. Statistical analysis demonstrated significant differences at the 200 mg/kg BW dose for the parameters of bronchiolar epithelial thickness and eosinophil count, as well as significant differences in mast cell counts at the 800 mg/kg BW dose and negative control group.
Co-Authors Bakhtiar, Muhammad Taher Evangelia, Beatrix Melani Ni Made Dwi Sandhiutami Saragih, Kristin Grave Gracia Tasya K. Siagian , Inneke