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N.L.P. Indi Dharmayanti

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Author-ID : 253298

Veterinary

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The Structure and Role of Segment 7 (Matrix Protein) and Segment 8 (Non Structural) in The Life Cycle and Virulence of Influenza Virus Dharmayanti, N.L.P. Indi
Indonesian Bulletin of Animal and Veterinary Sciences Vol 20, No 2 (2010)
Publisher : Indonesian Animal Sciences Society

Matrix (M) and Non Structural (NS) proteins are smallest segments of influenza virus genome. The noncoding sequences at each end include the sequences of 11 â 13 nucleotides at the 5â ends and 9 â 11 nucleotides at the 3â end which are highly conserved between seven or eight different RNA segments and very similar for A, B and C influenza viruses. Protein of M1 is an essential structural component of the virion and participates in other steps during the replication of influenza virus. During early viral infection, dissociation of M1 from RNP is required for entry of viral RNP into the cytoplasm of the host cell. On the other hand, NS1 is a multifunctions protein that performs a plethora of activities, which may additionally contribute toward efficient virus replication and virulence during infection. The role of NS1 are temporal regulation of viral RNA synthesis, control of viral mRNA splicing, enhancement of viral mRNA translation, regulation of virus particle morphogenesis, suppression of host immune/apoptotic responses, activation of phosphoinositide 3âkinase (PI3K); and involvement in strain-dependent pathogenesis. This paper reviews the structure and role of two proteins i.e. Matrix and Nonstructural to understand the character of influenza virus especially in virulence and pathogenesis ability of virus other than hemagglutinin (HA) and neuraminidase (NA) protein as known. Key words: Influenza virus, matrix protein, non structural protein

Genetic variation on internal protein matric (M1) and non structural protein (NS1) of Indonesian avian influenza virus H5N1 subtype N.L.P. Indi Dharmayanti
Jurnal Ilmu Ternak dan Veteriner Vol 16, No 1 (2011): MARCH 2011
Publisher : Indonesian Center for Animal Research and Development (ICARD)

The mutation and genetic variation of avian influenza virus ussually associated with Hemmaglutinin (HA) and Neuraminidase (NA). The HA and NA protein are surface glycoproteins which have role for receptor binding site of the virus, determine virus subtype and genetic variation occured in those proteins. On the other site, the virus have the internal protein that posses function for virus replication. This study analyzed the mutation on the the internal protein virus especially the Matrix (M1) and non structural (NS1) protein and its three dimensioanal structure of proteins. The methods used in this study were virus propagation, (Reverse Transcriptase Polymerase Chain Reaction) RT-PCR sequencing of M1 and NS1 and using DS Modeller dan DS Standalone from Discovery Studio for Modeling and Simulation to predict the three dimentional structure of the proteins. The result of this study showed that Indonesian AI H5N1 subtype had genetic variation internal protein and have no change on conserved of condition such as putative zinc finger and nuclear localization signal (NLS). Genetic variation that occured on PDZ motif of NS1 especially have human origin motif that might be correlated with virus adaptation on human. Key Words: Avian Influenza, Matrix (M1), Non Structural (NS1), Genetic Variation

The Structure and Role of Segment 7 (Matrix Protein) and Segment 8 (Non Structural) in The Life Cycle and Virulence of Influenza Virus N.L.P. Indi Dharmayanti
WARTAZOA, Indonesian Bulletin of Animal and Veterinary Sciences Vol 20, No 2 (2010): JUNE 2010
Publisher : Indonesian Center for Animal Research and Development

Matrix (M) and Non Structural (NS) proteins are smallest segments of influenza virus genome. The noncoding sequences at each end include the sequences of 11 – 13 nucleotides at the 5’ ends and 9 – 11 nucleotides at the 3’ end which are highly conserved between seven or eight different RNA segments and very similar for A, B and C influenza viruses. Protein of M1 is an essential structural component of the virion and participates in other steps during the replication of influenza virus. During early viral infection, dissociation of M1 from RNP is required for entry of viral RNP into the cytoplasm of the host cell. On the other hand, NS1 is a multifunctions protein that performs a plethora of activities, which may additionally contribute toward efficient virus replication and virulence during infection. The role of NS1 are temporal regulation of viral RNA synthesis, control of viral mRNA splicing, enhancement of viral mRNA translation, regulation of virus particle morphogenesis, suppression of host immune/apoptotic responses, activation of phosphoinositide 3–kinase (PI3K); and involvement in strain-dependent pathogenesis. This paper reviews the structure and role of two proteins i.e. Matrix and Nonstructural to understand the character of influenza virus especially in virulence and pathogenesis ability of virus other than hemagglutinin (HA) and neuraminidase (NA) protein as known. Key words: Influenza virus, matrix protein, non structural protein

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