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All Journal Health Notions Media Medika Muda Parapemikir Jurnal Ilmiah Farmasi
Prasetyowati Prasetyowati
Faculty Of Medicine, Diponegoro University, Indonesia
Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health

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Supplementation of Zinc Sulphate Decrease for Cytokine Levels TNF-Α, IL-1β and IL-6 in Multibacillary Leprosy Patients Joko Kurnianto; Hertanto W S; Prasetyowati Prasetyowati; Suharyo H. S.
Health Notions Vol 3, No 4 (2019): April
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hn30407

Abstract

Background: The role of zinc as an anti-oxidant and anti-inflammatory has been widely proven, this substance is relatively inexpensive and easily available to the public. Serum zinc levels of leprosy patients and patients with leprosy reactions are lower compared to healthy people, and proinflammatory cytokines including TNF-α, IL-1β and IL-6 play a role in the mechanism of leprosy reactions. Research on the effect of zinc supplementation on leprosy sufferers who have not experienced a reaction has not been done. Objective: To analyze the effect of 40 mg / day dose of zinc sulphate supplementation for 12 weeks on the levels of proinflammatory cytokines levels TNF-α, IL-1β and IL-6 in type MB leprosy patients. Method: This is an experimental study using a randomized control group pretest and posttest design. The study participants were MB patients with 121 patients who did not experience a leprosy reaction, the sample was taken randomly as many as 31 patients as a supplementation group (treatment), and 31 patients as Control group. BMI measurements, food intake by re-call method, Hb level using Hematology Analyzer, serum zinc levels using Atomic Absorption Spectrophotometry (AAS) method, TNF-α, IFN-γ, and IL-1β levels used the ELISA method. Data were analysed using chi-square and t-tests. Results: Zinc sulfate supplementation dose of 40 mg / day for 12 weeks in type MB leprosy patients was able to maintain a decrease in zinc levels of 1.22 pg / dL higher than leprosy patients who did not receive zinc supplementation, reduce levels of IL-1β (p=0.032). However, statistically there is insufficient evidence to reduce levels of TNF-α (p=0.063) and IL-6 (p=0.389) and risk factors. Conclusion: The study confirmed that 40 mg / day supplementation of zinc sulfate for 12 weeks in type MB leprosy patients able to maintain a decrease in serum zinc levels, reduce IL-1β levels. Keywords: Supplementation, Cytokines, Type MB leprosy
KAJIAN MENGENAI JENIS SPESIES MALASSEZIA DAN WARNA LESI PITIRIASIS VERSIKOLOR Widyawati Widyawati; Prasetyowati Prasetyowati; Subakir Subakir
Media Medika Muda Vol 2, No 3 (2017)
Publisher : Faculty of Medicine Diponegoro University

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Abstract

Pendahuluan: Pitiriasis versikolor (PV) merupakan infeksi jamur superfisial yang bersifat kronik, ditandai dengan adanya makula hipopigmentasi maupun hiperpigmentasi yang disertai dengan skuama halus. Terdapat 14 spesies Malassezia yang pada keadaan tertentu dapat berubah menjadi patogen dan menimbulkan beberapa kelainan pada kulit.Tujuan: Mengetahui jenis spesies Malassezia pada lesi hipopigmentasi dan hiperpigmentasi pitiriasis versikolorMaterial dan Metode: Penelitian ini merupakan penelitian deskriptif dengan pendekatan cross sectional. Dilakukan di sub bagian Dermatomikologi, Bagian/SMF Ilmu Kesehatan Kulit dan Kelamin RSUP dr Kariadi Semarang serta laboratorium Mikrobiologi FK UNDIP/RS dr Kariadi Semarang, dengan 80 sampel. Lesi PV diidentifikasi berdasarkan perubahan warna. Dilakukan pemeriksaan mikroskopis kerokan kulit dan KOH 10%, kemudian dilakukan kultur disertai dengan pemeriksaan gambaran morfologi, pemeriksaan biokimiawi asimilasi Tween 20, 40, 60, 80. Analisis data dengan menggunakan Uji Chi Square.Hasil Penelitian: Warna lesi yang paling banyak didapatkan pada penelitian ini adalah lesi hipopigmentasi (73%). Sedangkan lesi hiperpigmentasi sebanyak 27%.Spesies Malassezia yang berhasil diidentifikasi adalah Malassezia yamatoensis (76%), Malassezia furfur (23,8%), Malassezia equine (1,6%), dan Malassezia caprae (1,6%). Hasil analisis statistik antara jenis spesies dan warna lesi yang paling banyak, dengan menggunakan Uji Chi Square didapatkan (p=0,075)Kesimpulan: tidak didapatkan hubungan bermakna antara warna lesi dengan jenis spesies Malassezia Kata kunci: Malassezia sp, pitiriasis versikolor
Pengaruh Suplementasi Seng Sulfat 40 mg/hr Selama 12 Minggu terhadap Kadar Sitokin proinflamasi TNF-α, IL-1β dan IL-6 Pada Penderita Kusta Multi Basiler Joko Kurnianto; Hertanto WS; Prasetyowati Prasetyowati; Suharyo HS
Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 1 (2019): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v8i1.1293

Abstract

The role of zinc as an anti-oxidant and anti-inflammatory has been widely proven, this substance is relatively inexpensive and easily available to the public. Serum zinc levels of leprosy patients and patients with leprosy reactions are lower compared to healthy people, and proinflammatory cytokines including TNF-α, IL-1β and IL-6 play a role in the mechanism of leprosy reactions. Research on the effect of zinc supplementation on leprosy sufferers who have not experienced a reaction has not been done. Objective: To analyze the effect of 40 mg / day dose of zinc sulphate supplementation for 12 weeks on the levels of proinflammatory cytokines and the incidence of reactions in type MB leprosy patients. An experimental study with a randomized control group pre and post test design approach, the subjects of this study were MB patients with 121 patients who did not experience a leprosy reaction, the sample was taken randomly as many as 31 patients as a supplementation group (treatment), and 31 patients as Control group. BMI measurements, food intake by re-call method, Hb level using Hematology Analyzer, serum zinc levels using Atomic Absorption Spectrophotometry (AAS) method, TNF-α, IFN-γ, and IL-1β levels used the ELISA method. Data analysis using chi-square correlation statistical test and mean (mean) test. Zinc sulfate supplementation dose of 40 mg / day for 12 weeks in type MB leprosy patients was able to maintain a decrease in zinc levels of 1.22 pg / dL higher than leprosy patients who did not receive zinc supplementation, reduce levels of IL-1β (p: 0.032 ) However, statistically there is insufficient evidence to reduce levels of TNF-α (p: 0.063) and IL-6 (p: 0.389) and risk factors. Food intake is associated with the incidence of leprosy reactions (p 0.05).Keywords:Supplementation, cytokines, leprosy type MB.Conclusion: The most recent findings in this study were 40 mg / day supplementation of zinc sulfate for 12 weeks in MB type leprosy patients able to maintain a decrease in serum zinc levels, reduce IL-1β levels, and risk factors. Food intake correlated with the incidence of leprosy reactions
Co-Authors Hertanto W S Hertanto WS Joko Kurnianto Joko Kurnianto Subakir Subakir Suharyo H. S. Suharyo HS Widyawati Widyawati