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All Journal Alchemy : Journal of Chemistry
Wang-Hsien Ding
Department of Chemistry, National Central University, Chung-Li 320, Taiwan, R.O.C
Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Materials Science & Nanotechnology

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Optimization of Silylation for Parabens Determination by Gas Chromatography-Mass Spectrometry Djatmika, Rosalina; Ding, Wang-Hsien
ALCHEMY Vol 5, No 2 (2016): ALCHEMY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (640.488 KB) | DOI: 10.18860/al.v5i2.3743

Abstract

A low cost, environmental friendly and convenient method for parabens derivatization using Gas Chromatography-Mass Spectrometry (GC-MS) analysis is investigated. Derivatization is needed to enhance the thermal stability, detectability, and volatility of parabens to make them amenable for gas chromatographic analysis. This method involved on-line derivatization by silylating reagent: N-Methyl-N-tert-butyldimethylsilyltrifluoroacetamide (MTBSTFA), N,O-bis (trimethylsilyl) trifluoroacetamide (BSTFA), N-methyl-N-trimethylsilyltrifluoroacetamide (MSTFA), and N,O-bis(trimethylsilyl)acetamide (BSA). The variables affected the derivatization process, such as, types and volumes of silylating reagents, injection port temperature, and purge-off time, were evaluated to obtain the optimal condition for determination of parabens. The Relative Response Factors (RRF) was used as a parameter of parabens derivatization efficiency to obtain the best compromise condition of each variable. On a comprehensive level, a comparison of the optimal condition of each silylating reagent was evaluated. Moreover, 1 µL of MSTFA  at 260°C of injection port temperature and 2.5 min purge-off time (in splitless mode) obtained the most effective of derivatization process.
Co-Authors Rosalina Djatmika