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All Journal VALENSI Jurnal Jamu Indonesia Indonesian Journal of Jamu
Rizky Arcinthya Rachmania
Program Studi Farmasi, Fakultas Farmasi dan Sains, Universitas Muhammadiyah Prof. Dr. Hamka
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Other

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Studi In Silico Senyawa Alkaloid Herba Bakung Putih (Crinum Asiaticum L.) pada Penghambatan Enzim Siklooksigenase (COX) Rizky Arcinthya Rachmania; Hariyanti Hariyanti; Ririh Zikriah; Aditya Sultan
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 4, No. 2, November 2018
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (717.027 KB) | DOI: 10.15408/jkv.v4i2.7686

Abstract

Inflammation is a response to tissue injury involving the physiological process of cyclooxygenase enzyme activation which has two isoforms, cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes. The use of anti-inflammatory drugs of Non Steroidal Anti Inflammatory (AINS) and steroid groups has side effects in long-term use. The objective of this study was to find out eight active white herbic alkaloid compounds (Crinum asiaticum L.) to be used as anti-inflammatory by inhibiting COX-1 and COX-2 enzymes. Molecular docking method for the prediction of complex structures of proteins called ligand-protein docking using the PLANTS 1.2 software. where the lowest ChemPLP score which is free energy is the molecular tethering parameter. The herbaceous white herbaceae compound obtained the lowest CHEMPLP score of hippadine -83.3684 Kcal / mol and pratorimin -83.2661 Kcal / mol and aspirin comparator -67.3292 Kcal / mol and paracetamol -66.3535 Kcal / mol. Molecular docking in COX-2 shows lycobetaine -87.3991 Kcal / mol is lower than that of the celecoxib -85.3729 Kcal / mol comparator against the cyclooxygenase-2 receptor (COX-2). These results show that the white lycopene alkaloid compounds hyppadine, pratorimin and lycobetaine have better affinity and stability than the comparative compounds. The results of drug scans, hippadin, pratorimin and lycobetaine have the criteria for oral preparations. It can be concluded that herbaceous  white herbaceae are predicted to have potential as anti-inflammatory compounds.  
Molecular Docking Study of Isoflavonoid Erythrina variegata To Plasminogen Receptor as Thrombolytic Agent on Myocardial Infarction Disease Rizky Arcinthya Rachmania; Hariyanti; Dewi Susilawati
Jurnal Jamu Indonesia Vol. 7 No. 1 (2022): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v7i1.172

Abstract

Erythrina variegata is one of the plants that have efficacy as thrombolytic agent. Isoflavonoid compound has the potential to accelerate the changes of plasminogen which plays important role in the forming of fibrin, that causes the formation of fibrin clots that can clog the arteries thus causing myocardial infarction. This study aimed to look at the activity of isoflavonoid compounds from Erythrina variegata bark which are expected to be candidates for thrombolytic drugs. This research aims at looking for the interaction of isoflavonoid compounds of bark  which is expected can be thrombolytic drug candidates. The method used in this research was the molecular docking with Autodock Vina and PyMOL software. The results showed that the value of ΔG binding affinity as ligands standard streptokinase -8.4 kcal/mol and isoflavonoid derivatives that have ΔG binding affinity value was lowest for the folitenol -11.5 kcal / mol and orientanol C -11.4 kcal/mol. Can be concluded that isoflavonoid derivatives in Erythrina variegata have better binding potential compared to streptokinase as standard ligands.
Molecular Docking Study of Isoflavonoid Erythrina variegata To Plasminogen Receptor as Thrombolytic Agent on Myocardial Infarction Disease Rizky Arcinthya Rachmania; Hariyanti; Dewi Susilawati
Jurnal Jamu Indonesia Vol. 7 No. 1 (2022): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v7i1.172

Abstract

Erythrina variegata is one of the plants that have efficacy as thrombolytic agent. Isoflavonoid compound has the potential to accelerate the changes of plasminogen which plays important role in the forming of fibrin, that causes the formation of fibrin clots that can clog the arteries thus causing myocardial infarction. This study aimed to look at the activity of isoflavonoid compounds from Erythrina variegata bark which are expected to be candidates for thrombolytic drugs. This research aims at looking for the interaction of isoflavonoid compounds of bark  which is expected can be thrombolytic drug candidates. The method used in this research was the molecular docking with Autodock Vina and PyMOL software. The results showed that the value of ΔG binding affinity as ligands standard streptokinase -8.4 kcal/mol and isoflavonoid derivatives that have ΔG binding affinity value was lowest for the folitenol -11.5 kcal / mol and orientanol C -11.4 kcal/mol. Can be concluded that isoflavonoid derivatives in Erythrina variegata have better binding potential compared to streptokinase as standard ligands.
Co-Authors Aditya Sultan Dewi Susilawati Hariyanti Hariyanti Ririh Zikriah