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All Journal VALENSI JPSCR : Journal of Pharmaceutical Science and Clinical Research
Muhamad Widyo Wartono
Universitas Sebelas Maret
Chemistry Environmental Science Public Health

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Isolasi dan Identifikasi Senyawa Seskuiterpen dari Curcuma soloensis Val. (Temu Glenyeh) Soerya Dewi Marliyana; Muhamad Widyo Wartono; Fajar Rakhman Wibowo; Gesti Munasah
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 4, No. 2, November 2018
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (729.169 KB) | DOI: 10.15408/jkv.v4i2.7443

Abstract

Curcuma soloensis Val. is a family plant Zingiberaceae and is known as "temu gelnyeh". This plant has been used as a medicinal plant but has not been widely reported about its chemical components. Therefore, this study was carried out to isolation and identification of the chemical components of the C. soloensis Val. rhizome. Isolation was done by extraction, fractionation, and purification. The fractionation and purification of the compound were carried out using chromatography methods. The identification of the compound was determined by spectroscopic methods including 1D-NMR (1H NMR, 13C NMR) and 2D-NMR (HSQC, HMBC). Based on NMR spectra data analysis and compared with literature, the compound obtained yellow liquid was ar-turmerone (2-methyl-6- (4-methylphenyl) hept-2-en-4-on) which was a terpenoid sesquiterpene. Ar-turmerone is the first compound that found from Curcuma soloensis Val. rhizome.  
Steroid Β-Sitosterol Dari Kayu Batang Slatri (Calophyllum soulattri BURM. F) Soerya Dewi Marliyana; Muhamad Widyo Wartono; Ida Dahlia
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 6, No 1 (2021)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v6i1.44850

Abstract

Callophyllum soulattri Burm. F. merupakan salah satu spesies dari genus Callophyllum. Salah satu kandungan metabolit sekunder dari C. soulatrri adalah golongan senyawa steroid. Golongan steroid mempunyai beragam bioaktivitas antara lain antiinflamsi, antioksidan, antipoliferasi, antibakteri, antimalaria dan antikanker. Eksplorasi tumbuhan C. soulatrri masih terbatas oleh karena itu perlu dilakukan isolasi dan identifikasi metabolit sekunder dari tumbuhan tersebut. Satu senyawa golongan steroid telah berhasil diisolasi dan diidentifikasi dari ekstrak kayu batang C. soulattri. Metanol dipakai sebagai pelarut untuk maserasi, sedangkan fraksinasi dan pemurnian menggunakan metode Kromatgrafi Vakum Cair (KVC) yang dipantau dengan Kromatografi Lapis Tipis (KLT). Senyawa hasil isolasi ditentukan strukturnya dengan metode spektroskopi FTIR dan NMR (1H NMR, 13C NMR, HSQC dan HMBC) serta dibandingkan dengan pustaka. Berdasarkan hasil interpretasi spektra FTIR dan NMR, senyawa yang berhasil diisolasi dari ekstrak metanol kayu batang C. soulatrri adalah β-sitosterol berbentuk padatan berwarna putih.
Co-Authors Fajar Rakhman Wibowo Gesti Munasah Ida Dahlia Soerya Dewi Marliyana Soerya Dewi Marliyana