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All Journal Journal of Health (JoH) Jurnal Surya Medika
Raihana Raihana
Universitas Sari Mulia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Efek Ekstrak Etanol Akar Pasak Bumi (Eurycoma Longifolia, Jack) terhadap Ekspresi HRAS pada Organ Hati Tikus Galur Sprague Dawley pada Pemberian Doxorubicin Noval Noval; Raihana Raihana
Jurnal Surya Medika (JSM) Vol 5 No 1 (2019): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (888.766 KB) | DOI: 10.33084/jsm.v5i1.952

Abstract

Doxorubicin chemotherapy agents cause serious side effects in normal cells, especially in the liver and heart caused by free radicals. RAS is an important component of the signal transduction pathway that controls cell proliferation, differentiation and survival. The pasak bumi root (Eurycoma longifolia, Jack) has been reported to have acted as an antioxidant and hepatoprotector. This study aims to determine the effect of giving ethanol extract of pasak bumi root on HRAS expression in healthy mice given doxorubicin. This research was conducted by dividing the test animals into 7 groups, namely doxorubicin control group 4.67 mg / kgBB, group II control ethanol extract of pasak bumi roots 200 mg / kgBB, group III, IV and V were the treatment groups given doxorubicin 4.67 mg / kgBW with ethanol extract of the pasak bumi root, each 50 mg / kgBB; 100 mg / kgBB; 200 mg / kgBW, group VI solvent control and group VII healthy control. The study was continued by painting using an immunohistochemical method to see the expression of HRAS in each experimental group. Data analysis was performed by calculating per cent expressions, then proceed with statistical tests using SPSS. The results of statistical tests showed that there were significant differences between the doxorubicin control group (18.56 ± 1.85) and the treatment of group 5 (10.43 ± 1.71) and there were no significant differences between the doxorubicin control group (18.56 ± 1, 85) with group 3 treatment (17.80 ± 4.23) and group 4 treatment (16.70 ± 1.97). From the results of the study concluded that the ethanol extract of pasak bumi roots at a dose of 200 mg / KgBB can reduce the expression of HRAS in the administration of doxorubicin
Trigliserida dan Kolesterol Total sebagai prediktor mortalitas pasien stroke: literatur review Bagus Rahmat Santoso; Eirene E.M. Gaghauna; Raihana Raihana
Journal of Health (JoH) Vol 10 No 1 (2023): Journal of Health (JoH) - January
Publisher : LPPM STIKES Guna Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30590/joh.v10n1.459

Abstract

Stroke is the leading cause of morbidity and mortality worldwide, who rank in 3rd after heart disease and cancer. Data based on the results of Riskesdas 2018 the prevalence of stroke is 10.9% and 15.4% of stroke case caused Indonesia. The province with the 3rd highest incidence is South Kalimantan at 12.7% per mil. Hypertriglyceridemia and hypercholesterolemia are risk factors for ischemic stroke. Low triglyceride and total cholesterol levels contribute to intracerebral haemorrhage. This study to analyse the relationship of laboratory results triglycerides and total cholesterol to mortality in stroke patients. Method: Study are used literature review, searching online journals and sources from databases. Using keywords, namely stroke mortality, total cholesterol, and triglycerides. Results of the literature review, it was found that there were 18 journals were analysed that triglycerides and total cholesterol predictors of prognosis and mortality in stroke patients. Range of values affect is high triglyceride levels > 200 mg/dL and high total cholesterol levels >160-240 mg/dL affect the formation of atherosclerosis effect on blood vessel blockage occurs in ischemic stroke patients. Low triglyceride levels <150 mg/dL and low cholesterol <120-180 mg/dL causes malnutrition which can worse in stroke patients. Low levels of triglycerides and cholesterol effect on the integrity of cell membranes and resistance to rupture, resulting in prolonged bleeding. From this analysis it can be concluded that high or low levels of triglycerides and total cholesterol had effect on prognosis and mortality in stroke patients based on the pathophysiology that occurs.
Co-Authors Bagus Rahmat Santoso Eirene E.M. Gaghauna Noval Noval