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All Journal BIOTROPIC The Journal of Tropical Biology SRIWIJAYA JOURNAL OF MEDICINE
Hetti Rusmini
Departemen Farmakologi, Fakultas kedokteran Universitas Malahayati, lampung, Indonesia
Agriculture, Biological Sciences & Forestry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Pengaruh Pemberian Calcitriol terhadap Kadar Limfosit pada Tikus Putih (Rattus norvegicus) Galur Wistar Jantan yang Dipapar Asap Rokok Jordy Oktobiannobel; Hetti Rusmini; Retno Ariza Soeprihatini Soemarwoto; Syafa’atun Malihah
Biotropic : The Journal of Tropical Biology Vol. 5 No. 1 (2021): Biotropic, Volume 5 Nomor 1, 2021
Publisher : Program Studi Biologi, Fakultas Sains dan Teknologi, Universitas Islam Negeri Sunan Ampel Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29080/biotropic.2021.5.1.29-40

Abstract

The health impact for active and passive smokers is damage to the organs and respiratory tract. The body organs initially experience inflammation which increases the number of white blood cells, one of which is an increase in lymphocytes. One of the efforts to reduce the damage caused free radical by cigarette smoke is by consuming Calcitriol. Objective: To determine the effect of presenting Calcitriol on lymphocyte levels in male Wistar rats (Rattus norvegicus) exposed to cigarette smoke. Methods: This type of research is a pure experimental (true-experiment) using a pre and post-test research design with a control group design to check lymphocyte levels in male Wistar rats (Rattus norvegicus). 24 rats were divided into 6 groups simultaneously. Random, namely the control group 1 (exposed to cigarette smoke and not given Calcitriol), group 2 (exposed to cigarette smoke and not given Calcitriol), placebo control group (exposed to cigarette smoke and given olive oil), treatment 1 (exposed to cigarette smoke and given Calcitriol with a dose of 0.25 µgr / head), treatment 2 (exposed to cigarette smoke and given Calcitriol at a dose of 0.5 µgr / head) and treatment 3 (exposed to cigarette smoke and given Calcitriol at a dose of 1 µgr / head). Results: Paired t-test lymphocyte levels showed evidence that stated (p <0.05) in the K2 group (p = 0.014), the K3 group (p = 0.049), the P1 group (p = 0.012) and the P3 group (0.001) . Meanwhile, group K1 (p = 0.115) and group P2 (p = 0.066) had no statistical difference. Conclusion: Calcitriol administration can reduce lymphocyte levels in male Wistar rats exposed to cigarette smoke.
Pengar uh Gel Kulit Nanas Madu Terhadap Penyembuhan Luka Terbakar Derajat Dua Pada Tikus Putih (Rattus Novergicus) Hetti Rusmini; Asmia Djunishap; Muhammad Nurly Nuha Naufal; Muhammad Fikri Hanif
Sriwijaya Journal of Medicine Vol. 2 No. 3 (2019): Vol 2, No 3, 2019
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v2i3.48

Abstract

Kulit nanas (Ananas comosus. L) merupakan limbah dari olahan buah nanas yang populer dikonsumsi oleh masyarakat. Kulit nanas mengandung senyawa flavonoid yang mampu mempercepat proses penyembuhan luka bakar derajat 2. Penelitian ini bertujuan untuk mengetahui efek penyembuhan luka bakar dari gel kulit nanas pada tikus yang telah diberikan luka bakar derajat 2. Penelitian ini merupakan penelitian eksperimental dengan desain post test only control group. Ekstrak kulit nanas dibuat dengan menggunakan metode ekstraksi maserasi. Subjek penelitian yang digunakan dalam uji efektifitas penyembuhan luka bakar derajat 2 ini adalah tikus putih (Rattus novergicus). Sampel terdiri dari 5kelompok perlakuan yaitu kelompok yang diberi gel kulit nanas dengan konsentrasi 10%, 20%, dan 30% dan kelompok kontrol bioplacenton disertai kontrol negatif. Analisis data menggunakan One Way ANOVA. Hasil penelitian ini menemukan bahwa efektivitas gel kulit nanas dengan konsentrasi optimal 20% dengan efek penyembuhan setara dengan obat komersil bioplasenton.
Co-Authors Asmia Djunishap Jordy Oktobiannobel Muhammad Fikri Hanif Muhammad Nurly Nuha Naufal Retno Ariza Soeprihatini Soemarwoto Syafa’atun Malihah