Lukman Hakim
Fakultas Farmasi Universitas Gadjah Mada

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KAITAN PENGGUNAAN OBAT ANALGETIK DAN ANTI INFLAMASI NON STEROID DENGAN KEJADIAN GAGAL GINJAL KRONIK PADA PASIEN HEMODIALISIS DI RSU PKU MUHAMMADYAH YOGYAKARTA Woro Supadmi; Lukman Hakim
Jurnal Ilmiah Farmasi Vol. 9 No. 2 (2012): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol9.iss2.art2

Abstract

Gagal ginjal kronik merupakan masalah kesehatan, sosial dan ekonomi dengan peningkatan insidensi, prevalensi dan morbiditas. Penelitian ini bertujuan untuk mengetahui apakah ada kaitan dan nilai odds ratio antara penggunaan analgetik dan OAINS dengan kejadian GGK di RSU PKU Muhammadiyah Yogyakarta. Penelitian ini menggunakan rancangan case control, kelompok kasus adalah pasien gagal ginjal kronik yang melakukan hemodialisa dan kelompok kontrol adalah pasien yang melakukan rawat inap tidak terdiagnosa GGK. Data sekunder diperoleh dari rekam medik pasien, data primer diperoleh melalui wawancara mendalam dengan panduan lembar pertanyaan. Data dianalisis dengan tabel 2x2 chi-square. Hasil penelitian menunjukkan bahwa penggunaan analgetik tidak berkaitan dengan kejadian GGK (OR 0,1;p>0,05;CI 0,018-0,366). Penggunaan OAINS berkaitan dengan kejadian GGK (OR 4,4; p<0,05;CI 0,906-21,97). Penggunaan analgetik dan OAINS berkaitan dengan kejadian GGK (OR 5,1;p<0,05;CI 1,057-24,78). Lama penggunaan analgetik tidak berkaitan dengan kejadian GGK (OR 1,4;p>0,05;CI 0,307-5,94), jumlah tablet penggunaan analgetik berkaitan dengan kejadian GGK (OR 23;p<0,05;CI 3,981-131). Lama penggunaan OAINS tidak berkaitan dengan kejadian GGK (OR 0,4;p>0,05;CI 0,018-7,29), jumlah tablet penggunaan OAINS berkaitan dengan kejadian GGK (OR 12;p<0,05;CI 0,936-153). Lama penggunaan analgetik dan OAINS tidak berkaitan dengan kejadian GGK (OR 0,6;p>0,05;CI 0,036-6,9), jumlah tablet penggunaan analgetik dan OAINS tidak berkaitan dengan kejadian GGK (OR 1,1;p>0,05;CI 0,138-7,934).Kata kunci : analgetik, faktor risiko, GGK (Gagal Ginjal Kronik), OAINSABSTRACTChronic renal failure is a matter of health, social and economi with increasing incidence, prevalence and morbidity. This study was aimed to observe assosiation between the used of analgesics and NSAIDs and calculate odds ratio of chronic renal failure incidence at PKU Muhammadiyah Hospital in Yogyakarta. The study used analytical observation with case control desingn,group of case cosisted as chronic renal failure patients who do hemodialysis and group of control who are not diagnosed with chronic renal failure. Secondary data were obtained from patient’s medical records, the primary data were obtained through indepth interview by guided questionnaire. Data analysis was using the 2x2 table and analyzed with chi square test to find out the correlation and the odds ratio between the use of analgesics and NSAIDs of chronic renal failure incidance. The used of analgesics not assosiation of chronic renal failure incidence (OR 0.1;p>0.05;CI 0.018 to 0,366). The used of NSAIDs assosiation of chronic renal failure incidence (OR 4.4;p< 0,05;CI 0.906 to 21.97). The used of analgesics and NSAID assosiation of chronic renal failure incidence (OR 5.1;p<0.05;CI 1.057 to 24.78). Duration of the used of analgesics not assosiation of renal failure incidence (OR 1.4;p>0.05;CI 0.307 to 5.94), the used total tablets analgesics correlation of chronic renal failure incidence (OR 23;p<0.05;CI 3.981 to 131). Duration of the used of NSAIDs was not assosiation of chronic renal failure incidence (OR 0.4;p>0.05;CI 0.018 to 7.29), number of totals tablets NSAIDs assosiation of chronic renal failure incidence (OR 12;p<0.05;CI 0.936 to 153). Duration of the used of analgesics and NSAIDs were not assosiation of chronic renal failure incidence (OR 0.6;p>0.05;CI 0.036 to 6.9), number of totals tablets to the used of analgesics and NSAIDs were not assosiation of chronic renal failure incidence (OR 1.1;p>0.05;CI 0.138 to 7.934).Keywords: analgesics, chronic renal failure, NSAIDs, risk factors
EVALUATION THE EFFICIENCY OF INPATIENT DRUG DISTRIBUTION IN THE PHARMACY DEPARTEMENT OF TARAKAN HOSPITAL IN CENTRAL JAKARTA Ika Purwidyaningrum; Lukman Hakim; Sri Wahyuni Pujitami
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 2, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.53

Abstract

Drug management in Hospital which consist of stages are selection, procurement, distribution and use. Result of preliminary observation done in Pharmacy departement of Tarakan Hospital found some inefficiency problem in distribution steps such as expired and damage control, conformity of record to physical checks on drug management, etc. Therefore, it necessary to evaluation the efficiency rate of inpatient ward drug management distribution. Research design was descriptive, retrospective and concurrent with the evaluation of documents relating to inpatient drug distribution process. The study used a sample of drugs including Class A medicines criteria. Data collected in the form of qualitative and quantitative data from observations of documents and interviews with relevant officers. Data was presented in tabular and textual descriptions. Data evaluation was descriptive using SPSS. Measurement of the efficiency of drug distribution was done by using indicators of the efficiency of Depkes and WHO, then compared with that indicator to determine the existence of inefficiency. The results showed, that according to several indicators inpatient ward drug distribution was not been efficient, inefficiency drug management indicators at this stage of the distribution occurs on a match between the physical card stock while (93.27%).Damaged and / or expired drugs in 2008 was 0.23% in 2009 was 0.48%. Prescriptions are not served in 2008 was 1.52%, 2.28% in 2009. TOR in 2008 was 6 times and in 2008 was 6.9 times. Efficient distribution of drugs already on the length of service time and the availability of prescription drugs Key words: drug distribution, efficiency, Pharmacy departement of Tarakan Hospital
DIGOXIN DOSE EVALUATION ON HEART FAILURE PATIENTS WITH RENAL DISFUNCTION IN RSUP DR. SARDJITO, YOGYAKARTA Jhonson P Sihombing; Lukman Hakim; AM Wara Kusharwanti
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 1, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.20

Abstract

Digoxin is a medicine with narrow therapeutic index. Digoxin is widely used for heart failure treatment. Adjustment of digoxin dose is needed in patient with renal dysfunction. This research were done to evaluate digoxin dose in heart failure patient with renal dysfunction. This research was retrospective and prospective research, performed in Dr. Sardjito hospital during January 2010 to March 2011. Data were collected from patient medical record and then evaluated with descriptive method. From 43 patients, percentage men compare to women were 56 % : 44 %. Most patients come from age of 50 – 59 (34.88%). Dose calculation based on pharmacokinetic concept found that some of digoxin dose in patients were exceed digoxin therapeutic concentration. From 19 women patients there were 11 patients use digoxin dose exceed digoxin therapeutic concentration when calculate by pharmacokinetic while from 24 men patients there were 14 patients use digoxin dose exceed digoxin therapeutic concentration when calculate by pharmacokinetic. Dose recalculation method was mostly based on literature data particularly for pharmacokinetic parameter values i.e. volume distribution, half life, and clearance. Therefore, the corrected doses suggested in this thesis should be regarded as theoretical estimates. Furthermore, it was also found that patients did not get appropriate loading dose of digoxin. However, drug dosing for digoxin were individual dose, therefore overall found that patient clinical outcome was generally better. Keywords : digoxin, heart failure, renal dysfunction, clinical outcome