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Pengaruh Disleksia terhadap Perkembangan Anak Dhila Thasliyah; Anjely Doni Lasmi; Visakha Vidyadevi Wiguna
Jurnal Ilmiah Universitas Batanghari Jambi Vol 22, No 1 (2022): Februari
Publisher : Universitas Batanghari Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33087/jiubj.v22i1.1781

Abstract

The purpose of preparing this article is to understand more deeply about effect of dyslexia in children aged 1 to 5 years old. The method used is a literature study from various sources, such as: 1) journal reviews, 2). scientific writing articles. Selection of journals and articles focused on children with dyslexia, while reviews of articles and journals were carried out in the last 10 years from 2010-2021. Dyslexia is defined as a syndrome that has difficulty learning the components of words and sentences as well as difficulties in learning about everything related to time. The risk factors for dyslexia in children are genetic and family environment. The impact of dyslexia on children’s development can be in the form of difficulties in reading skills, personality, behavior, and quality of life disorders. In addition, it also affects language development disorders, declarative consolidation disorders during sleep, and dyslexia comorbidities.
POTENSI PITAVASTATIN DENGAN NANOPARTIKEL POLY(DL-LACTIDE-CO-GLYCOLIDE) (PLGA) DRUG DELIVERY SYSTEM SEBAGAI TERAPI ADJUVAN PADA PENYAKIT JANTUNG KORONER Visakha Vidyadevi Wiguna; Abiyyu Didar Haq; Luh Gde Sri Adnyani Suari
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 3 (2022): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.3 Edisi Desember 202
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i3.453

Abstract

ABSTRACT Background: During COVID-19 pandemic, people’s mobility is decreased. This phenomenon leads to the increase of sedentary lifestyle hence increasing the risk of cardiometabolic diseases. One of the disease that has a strong connection with sedentary lifestyle is Coronary Artery Disease (CAD). CAD is the most common cardiovascular disease that causes death contributing as much as 12% of all death in the world. Percutaneous coronary intervention (PCI) therapy in the acute phase of myocardial infarct can lower the infarct area but the risk of ischemic-reperfusion injury limits its therapeutic effect. Methods: This literature review uses journal articles that are sourced from online databases such as PubMed and Google Scholar. The literature search utilized several keywords such as “pitavastatin”, “drug delivery system”, “nanoparticle”, “PLGA”, “myocardial infarction”, “ischemic-reperfusion injury”. The search yielded 34 relevant literatures which used in this literature review Discussion: Pitavastatin is a statin which possesses a significant effect on LDL-C, TG, and HDL-C. Furthermore, pitavastatin also possess cardioprotective effect on ischemic-reperfusion injury by decreasing oxidative stress and increasing intracellular antioxidant. PLGA nanoparticle is proven to increase the therapeutic effect of pitavastatin because of its ability to deliver timely and its anti-inflammatory effect. . Conclusion: Pitavastatin encapsulated by PLGA nanoparticle has the ability to prevent ischemic-reperfusion injury. Current therapeutic strategy has not been able to deliver pitavastatin into the infarct site adequately in the timely manner hence PLGA needed as drug delivery system.