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All Journal Cermin Dunia Kedokteran JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Hanny Setyowati
Department of Research and Development, Borobudur Natural Industry, Semarang, Indonesia
Health Professions Medicine & Pharmacology Public Health

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Gambir (Uncaria gambir Roxb) as Natural Cosmeceutical Agent Hanny Setyowati
Cermin Dunia Kedokteran Vol 44, No 3 (2017): Infeksi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v44i3.836

Abstract

Uncaria gambir contains varying amounts of polyphenols, mainly catechins. Catechin has a photo-protection activity which can be applied as sunscreen. The future goal of this cosmeceutical product is to prevent skin photo-damaging by UV-radiation.Uncaria gambir mengandung banyak komponen polifenol, terutama catechin. Catechin, sebagai senyawa utama tanaman gambir, memiliki aktivitas perlindungan terhadap cahaya matahari sehingga dapat diaplikasikan dalam sediaan tabir surya. 
Potential use of Purslane (Portulaca oleracea L.) as alternative wound healing therapy Hanny Setyowati
Cermin Dunia Kedokteran Vol 44, No 11 (2017): Kardiovaskuler
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v44i11.707

Abstract

Portulaca oleraceae (Indonesian name: Krokot) is a herbaceous succulent annual plant, distributed in tropical region. Chemical constituents such as flavonoids, alkaloids, fatty acids, terpenoids, polysaccharides, vitamins, sterols, proteins, and minerals have been isolated from this plant. The pharmacological properties, based on scientific research, are claimed as antibacterial, antiulcerogenic, anti-inflammatory, antioxidant, and especially for wound-healing. Triterpenoids and flavonoids play an important role, promotes wound contraction and increases epithelialization rate in the wound-healing process.Portulaca oleraceae (nama Indonesia: Krokot) adalah tumbuhan perdu sepanjang musim, tersebar di daerah tropis. Senyawa kimia seperti flavonoid, alkaloid, asam lemak, terpenoid, polisakarida, vitamin, sterol, protein, dan mineral telah diisolasi dari tanaman ini. Aktivitas farmakologis, berdasarkan hasil penelitian, dilaporkan sebagai antibakteri, antiulkus, antiinflamasi, antioksidan, dan terutama untuk penyembuhan luka. Triterpenoid dan flavonoid memiliki peran penting, yakni menstimulasi penyempitan bekas luka dan mempercepat penutupan luka.
Formulation of chewable lozenges of Som Jawa (Talinum paniculatum (jacq.) gaertn) leaves extract applied as antiscorbut Candida albicans Hanny Setyowati; Wahyuning Setyani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 1, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss1.art4

Abstract

Background: The bioactive compounds of Som Jawa (Talinum paniculatum (Jacq.) Gaertn) have many variations;one of them is flavonoid. This compound has antifungal activity towards Candida albicans, which the leading cause of topical infection. Chewable lozenges are one of the novel methods of delivering drugs for local action, especially in the mouth. Objective: To formulate chewable lozenges from Som Jawa leaves extract and evaluate their active substances.Methods: Extraction was done by rmaceration method with ethanol. The extract was evaporated using a rotary evaporator, then followed by a phytochemical investigation to express the active ingredients inside extract. Colour test was used to identify active ingredients. Som Jawa leaves extract was then formulated into chewable lozenges. Testing of physical properties of the chewable lozenges includes organoleptic test, weigh uniformity, hardness, elasticity, friability, chewiness and moisture content. Antifungal activity was tested by using a diffusion method. Result: Som Jawa leaves extract with the concentration of 50% can inhibit the growth of Candida albicans with inhibition zone diameter of 22.69 mm. The organoleptic test resulted that the dosage is odourless, brown, and chewy. Weigh uniformity resulted that all lozenges were meet the British Pharmacopoeia range with the CV < 5%. The hardness test resulted for approximately of 0.2732 Kgf. The average of elasticity, friability, and chewiness respectively was 0.0826 Kgf, 6.046 mm, and 0.4998 Kgf.mm. Conclusion: This formula chewable lozenge was potential as alternative herbal medicine for topical infection.
Co-Authors Wahyuning Setyani