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Creatine-kinase concentration of the cerebrospinal fluid in childhood acute bacterial meningitis Fx. Wikan Indrarto, Fx. Wikan Indrarto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 31, No 04 (1999)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (147.675 KB)

Abstract

Background: Acute bacterial meningitis is one of paediatric emergency cases which results in high morbidity and mortality. Diagnostic procedures using cerebrospinal fluid (CSF) are often unsatisfactory. A simple and rapid procedure is required for early diagnosis and prompt treatment.Objectives: The aims of this study were to assess total cerebrospinal fluid creatine-kinase (CSF-CK) level in childhood acute bacterial meningitis and to assess the diagnostic values of CSF-CK level compare with routine CSF analysis (i.e. cell count, morphology, chemical, C reactive protein and culture) which is accepted as diagnostic gold standard for acute meningitis.Materials and methods: All patients hospitalized in the Pediatric Department Sardjito Hospital for suspected acute bacterial meningitis in July-December 1998, underwent lumbar puncture. The level of CSF-CK and routine analyses were examined for diagnosis acute bacterial meningitis.Results: Forty five children with suspected meningitis were included in this study. CSF-CK 16 U/I had sensitivity 50%, specificity 80%, positive predictive value 42%, negative predictive value 85% and likelihood ratio 2,75. Mean of CSF-CK in childhood acute bacterial meningitis was 82,84 U/I.Conclusion : CSF-CK level was not sensitive, but it is a specific diagnostic test for childhood bacterial meningitis.Key words: acute bacterial meningitis - CK-CSF - diagnostic test
Creatine-kinase concentration of the cerebrospinal fluid in childhood acute bacterial meningitis Fx. Wikan Indrarto Fx. Wikan Indrarto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 31, No 04 (1999)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (147.675 KB)

Abstract

Background: Acute bacterial meningitis is one of paediatric emergency cases which results in high morbidity and mortality. Diagnostic procedures using cerebrospinal fluid (CSF) are often unsatisfactory. A simple and rapid procedure is required for early diagnosis and prompt treatment.Objectives: The aims of this study were to assess total cerebrospinal fluid creatine-kinase (CSF-CK) level in childhood acute bacterial meningitis and to assess the diagnostic values of CSF-CK level compare with routine CSF analysis (i.e. cell count, morphology, chemical, C reactive protein and culture) which is accepted as diagnostic gold standard for acute meningitis.Materials and methods: All patients hospitalized in the Pediatric Department Sardjito Hospital for suspected acute bacterial meningitis in July-December 1998, underwent lumbar puncture. The level of CSF-CK and routine analyses were examined for diagnosis acute bacterial meningitis.Results: Forty five children with suspected meningitis were included in this study. CSF-CK 16 U/I had sensitivity 50%, specificity 80%, positive predictive value 42%, negative predictive value 85% and likelihood ratio 2,75. Mean of CSF-CK in childhood acute bacterial meningitis was 82,84 U/I.Conclusion : CSF-CK level was not sensitive, but it is a specific diagnostic test for childhood bacterial meningitis.Key words: acute bacterial meningitis - CK-CSF - diagnostic test
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