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All Journal Acta Pharmaciae Indonesia : Acta Pharm Indo Journal of Global Pharma Technology
Ade Martinus
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Medicine & Pharmacology

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Perbandingan Stabilitas Aspirin dalam Asam Klorida dan Dalam Dapar Fosfat Sebagai Parameter Pemilihan Medium Disolusi Rehana Rehana; Ade Martinus
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 4 No 2 (2016): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (130.626 KB) | DOI: 10.20884/1.api.2016.4.2.1465

Abstract

Aspirin cenderung dihidrolisis sebagai asam salisilic dan asam asetat , sehingga stabilitas aspirin pada asam klorida dan fosfat buffer adalah parameter penting dalam pilihan medium disolusi . Tujuan dari penelitian ini adalah untuk membandingkan stabilitas aspirin dalam HCl 0,1 N dan fosfat buffer pH 7.4. Penelitianyang dilakukan merupakan penelitian laboratorium eksperimental meliputi analisis aspirin secara menurun setiap jam selama 6 jam yang dilarutkan dalam HCl 0,1 N dan dapar fosfat pH 7,4 menggunakan metode spektrofotometri, waktu yang dihitung adalah ketika aspirin 10 % terhidrolisa ( t10 % ) di kedua media , dan dibandingkan t10 % aspirin HCl 0,1 N dan dapar fosfat pH 7.4. Hasil penelitian menunjukkan bahwa aspirin lebih stabil ( p = 0,003 ) di buffer fosfat pH 7,4 ( t10 % = 445 menit ) dibandingkan HCl 0,1 N ( t10 % = 389 menit ).
The Reconstruction Procedure Using Osteocutaneous Vascularzed Fibula Graft in Limb Salvage Surgery for Recurrence Adamantinoma of Tibia Ade Martinus
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Introduction Adamantinoma is a very rare malignant bone tumor. The recurrence case seems to have more rapid enlarges and more aggressive invasion of surrounding soft tissue. Recently limb salvage has become the primary method of bone tumor treatment due to oncologist orthopaedic surgical advancement and more accurate imaging techniques. The osteocutaneous fibula graft is one of the advance option for intercalary reconstruction of the defect after bone tumor resection. The objectives of this case report are to present the reconstruction procedure of recurrence primary bone tumor using osteocutaneous fibular graft. Case Report.22 year’s old male with mass on right leg that gradually increased in size. He was previously diagnosed to have an adamantinoma, excised in other hospital 5 years ago. Radiograph and MRI examination support a recurrence adamantinoma of tibia and was confirmed by histopathologic result. Discussion we performed a limb salvage procedure via wide excision and reconstruction using osteocutaneous fibular ­graft. We were able to preserve the anterior tibial and posterior tibial neurovascular bundle. The recipient anterior tibial artery and vein was chosen to anastomose to donor vessels. The flap is vital and the patient discharged on 5th day. Conclusion: The limb salvage surgery with reconstruction procedure using osteocutaneous vascular zed fibula graft is a feasible surgical treatment in case of recurrence adamantinoma of tibia. Osteocutaneous fibula graft has been proven to be an ideal choice due to very high bony union rates, provide well-perfused bone, the capability of osteogenesis, and improved regional circulation. Keywords: Adamantinoma, Recurrence, Intercalary reconstruction, Osteocutaneous fibula graft, Limb salvage surgery.
Co-Authors Rehana Rehana