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All Journal Acta Pharmaciae Indonesia : Acta Pharm Indo
Esti Dyah Utami
Department of Pharmacy, Faculty of Health Sciences, Universitas Jenderal Soedirman. Purwokerto (Indonesia)
Medicine & Pharmacology

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Hubungan Karakteristik Pasien dengan Kepatuhan Minum Obat dan Kualitas Hidup Pasien Rawat Jalan Strok Iskemik di RSUD Banyumas Nindita Rachmania; Nia Kurnia Sholihat; Esti Dyah Utami
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 8 No 1 (2020): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (242.812 KB) | DOI: 10.20884/1.api.2020.8.1.2359

Abstract

Pasien strok memiliki risiko tinggi pada terjadinya strok berulang sehingga pasien strok perlu diberikan terapi pencegahan yaitu obat antiplatelet. Kualitas hidup pada pasien pasca strok dapat membantu mengevaluasi terapi yang telah diterapkan. Tujuan penelitian ini adalah untuk mengetahui karakteristik pasien apa saja yang berhubungan terhadap kepatuhan minum obat dan kualitas hidup pasien strok iskemik di RSUD Banyumas. Jumlah sampel penelitian sebanyak 44 orang dan menggunakan teknik total sampling. Kepatuhan minum obat diukur menggunakan kuesioner MARS-5 sedangkan kuesioner WHOQOL-Bref digunakan untuk mengukur kualitas hidup. Hasil yang didapat pada penelitian ini adalah tidak ada hubungan antara karakteristik pasien yaitu jenis kelamin, usia, pendidikan, pekerjaan dan status tinggal terhadap kepatuhan minum obat antiplatelet. Terdapat hubungan yang signifikan antara karakteristik pasien yaitu usia (p=0.004), pendidikan (p=0.000), pekerjaan (p=0.013) dan status tinggal (p=0.042) terhadap kualitas hidup pasien strok iskemik.
Psidium guajava leaves extract decreased leukocytes and lymphocytes count in Complete Freund's Adjuvant-induced arthritis rats Hanif Nasiatul Baroroh; Rupa Lesty; Esti Dyah Utami; Nur Ayunie Zulkepli
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.1.5789

Abstract

Background: Psidium guajava is one of the herbal plants that has demonstrated antioxidant and anti-inflammatory properties. Objective: This study aimed to determine the effect of P. guajava leaves extract on leukocytes and lymphocytes in rats. Methods: Fifty rats were divided into five groups. Complete Freund’s Adjuvant (CFA) was employed to generate an animal model of arthritis. Group I (arthritis control) received CMC Na, group II (positive control) received dexamethasone 3 mg/kg BW, and groups III-V received 250, 500, and 750 mg/kg BW of the ethanol extract of P. guajava leaves orally. Total leukocyte counts were calculated on days 13 and 29, and on day 29, the histological joints were inspected. Results: The P. guajava leaves extract decreased the number of lymphocytes and total leukocytes. Before and after treatment, the group receiving doses of 250 mg/kg BW and 750 mg/kg BW of the extract showed a significant decrease in leukocytes. With treatment of 250, 500, and 750 mg/kg BW of P. guajava leaves ethanol extract, the lymphocyte count was also reduced. The P. guajava leaves extract at 750 mg/kg body weight showed the greatest effectiveness in suppressing leukocytes and lymphocytes. Conclusion: The extract of P. guajava leaves has the potential to be developed as an anti-inflammatory for arthritis.
Co-Authors Hanif Nasiatul Baroroh Nia Kurnia Sholihat Nindita Rachmania Nur Ayunie Zulkepli Rupa Lesty