<![CDATA[ABSTRACTBackground:   Cirrhosis patients  with renal failure  are  at  high  risk  for  death  and  reduced survival  as  compared  with  those  without  renal failure,  and have poor prognosis.  Some studies  have suggested  that  cystatin  C did  more  accurate  than creatinine /0  detect glomerulusfiltration   rate (GFR) in patients  with cirrhosis.  Model  of End Stage  Liver Disease  (MELD) score can be used in patients  with cirrhosis  with variously  Widely severity  disease  and etiologies.  Until nmv, there is no study about correlation  between  levels of cystatin  C to disease severity  in cirrhosis based on MELD score.Objective:  This present  study  was to investigate  the correlation  between levels of cyst at ill C with disease severity  in cirrhosis  based on MELD score.Method:  Study  design  was cross sectional s t u d y,    This     study      was    conducted         at Gastoenterohepatology        outpatient    clinic   and Internal Medicine  ward of Dr Sardjito  General Hospital,    Yogyakarta.   Inclusion    criteria    were patients   with   cirrhosis   diagnosed    by  clinical criteria,  laboratory  and  USG.findillg,  age  >  18 years,  had  complete  medical  record  and  obtained informed consent. Exclusion criteria were chronic kidney  disease,  sepsis, hepatocellutare  carcinoma, used high doses  of steroid, had thyroid dysfunction. hypertension  and diabetes mellitus.Result:  The mean  of cystatin  C based  on categorical   MELD   score  were  MELD   <10  = 0.93±0.19  mgll;  MELD   IO-19=1.08±0.26   mg/l; MELD  20-29  =  1.25±O.27 mgll;  MELD  30-39  = 2.49 mg/l and  MELD  >40  = 2.43 mgll;  0)=0.013; 95%  CI  0.000-0.061).    There  was  a  significant correlation  between  cystatin  C to MELD  score  as demonstrated  byp=O.OOOand r=0.485.Conclusion:    Our data  suggested   a significant    correlation    with  medium   strength between cystatin  C to severity  disease  of cirrhosis based 011 MELD score. Keywords:  cirrhosis,  cystatin  C, MELD score  ]]>
