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All Journal Acta Biochimica Indonesiana Abdimas Universal
Veronika Ika Budiastuti
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Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Law, Crime, Criminology & Criminal Justice Social Sciences

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Pelatihan PELATIHAN PEMBELAJARAN KLINIK TERINTEGRASI DENGAN MENGGUNAKAN MODUL YANG BERBASIS PENDEKATAN SYMPTOM PADA PRECEPTOR DI PUSKESMAS Siti Munawaroh; Veronika Ika Budiastuti; Eti Poncorini Pamungkasari; Atik Maftuhah; Dian Nugroho; Maria Sekar Cahyaningrum; Stefanus Erdana Putra; Muhammad Hafidzan
Abdimas Universal Vol. 3 No. 2 (2021): Oktober
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Balikpapan (LPPM UNIBA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36277/abdimasuniversal.v3i2.137

Abstract

Primary healthcare is one of the vehicles in learning for students of the medical profession. The preceptor clinic in primary healthcare is expected to guide and direct students studying there so that it can be effective. Integrated learning in all fields of medical science that is applied is expected to prepare medical graduates who are ready to enter the community. The symptom and sign approach is considered one of the effective methods in learning primary healthcare. Therefore, we intend to provide integrated clinical learning training using a module based on the symptom approach at primary healthcare. This community service involves ten primary healthcare located in the Boyolali and Klaten areas. The activity begins with exploring the problems that exist when guiding students of the medical profession who study primary healthcare. Then proceed with introducing guidance methods using clinical learning guides with a sign and symptom approach and ends with training evaluations. The participants of this activity received this training and provided some input regarding the existing modules. Suggestions from the primary healthcare preceptors were used as input to improve the modules that had been prepared.
Dose-dependent anticholesterol effects of Fuji apple simplicia in a rat model of metabolic syndrome Himawan Pramudana Amiruddin; R. Prihandjojo Andri Putranto; Amalina Shabrina; Veronika Ika Budiastuti
Acta Biochimica Indonesiana Vol. 9 No. 1 (2026): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.233

Abstract

Background: Metabolic syndrome-associated dyslipidemia increases cardiovascular disease risk. Fuji apples (Malus domestica) contain bioactive compounds that may modulate cholesterol metabolism. Objective: To evaluate dose-dependent anticholesterol effects of Fuji apple simplicia in metabolic syndrome rats. Methods: Thirty male Wistar rats were allocated into five groups (n=6): negative control, positive control (metabolic syndrome without treatment), and three treatment groups receiving simplicia at 150, 300, or 450 mg/200 g body weight/day for 28 days. Metabolic syndrome was induced using high-fat diet and streptozotocin-nicotinamide injection. Total cholesterol was measured using enzymatic colorimetric assay and analyzed using mixed ANOVA. Results: Simplicia produced significant dose-dependent cholesterol reductions compared to positive control (p<0.001). Reductions were 71.77 mg/dL (34.09%), 100.53 mg/dL (47.78%), and 112.02 mg/dL (52.75%) at doses of 150, 300, and 450 mg/200 g body weight/day, respectively. Conclusion: Fuji apple simplicia exhibits significant anticholesterol activity in metabolic syndrome rats through a dose-dependent mechanism, supporting its potential as a complementary intervention for hypercholesterolemia management in metabolic syndrome.
Co-Authors Amalina Shabrina Atik Maftuhah Dian Nugroho Eti Poncorini Pamungkasari Himawan Pramudana Amiruddin Ibnu Ridhwan Maria Sekar Cahyaningrum Muhammad Hafidzan R. Prihandjojo Andri Putranto Siti Munawaroh Stefanus Erdana Putra Tian Wahyu Kinasih Ulya Amalia Utiya Nabila Maulani Vita Yuniar Saraswati Wida Wahyu Puspitaningrum