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All Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Kedokteran Meditek
Visakha Revana Irawan
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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The Association between Metaplasia and Gastric Malignancy with Helicobater pylori Infection Riki Tenggara; Visakha Revana Irawan
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 18, No 2 (2017): VOLUME 18, NUMBER 2, AUGUST 2017
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (373.519 KB) | DOI: 10.24871/182201794-97

Abstract

Background: Helicobacter pylori (H. pylori) infection is the main cause of peptic ulcer disease, gastric mucosa metaplasia, and gastric malignancy. The hypothesis of this study is whether there’s an association between metaplasia and gastric malignancy with H. pylori infection.Method: We conducted a retrospective study on 1.127 dyspepsia subjects who performed endoscopy between 2001 to 2011 at a hospital in North Jakarta. Data is obtained based on endoscopy and histopathology data. Investigation of H. pylori in this study using histopathology examination.Results: Of the 1.127 dyspepsia subjects who performed endoscopy and biopsy, there were 130 (11,54%) H. pylori-positive subjects. Gender proportion was composed of 55,37% men and 44,63% women, with median age was 47 years. On the histopathology examination, we obtained 45 metaplasia subjects with median age of 45 years and 7 malignancy subjects with median age of 64 years. Metaplasia was found in 33 of 997 (3,31%) H. pylori-negative subjects and 12 of 130 (9.23%) H. pylori-positive subjects. All gastric malignancy subjects had H. pylori-negative results.Conclusion: There was an association between metaplasia and H. pylori infection, but no association between gastric malignancy and H. pylori infection.
Gangguan Fungsi Tiroid pada Penggunaan Amiodaron David Susanto; Visakha Revana Irawan
Jurnal Kedokteran Meditek VOL. 22 NO. 58 JANUARI-APRIL 2016
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v22i58.1267

Abstract

AbstrakAmiodaron merupakan obat anti aritmia yang efektif untuk mengontrol ritme aritmia yang mengancam, namun pengobatan ini dapat memberikan berbagai efek samping. Disfungsi tiroid merupakan efek samping yang cukup sering terjadi selama terapi amiodaron. Hal ini disebabkan karena tingginya jumlah ion iodin dan adanya hambatan pada aktivitas enzim deiodinase. Disfungsi tiroid yang disebabkan oleh amiodaron, memiliki variasi klinis, mulai dari tanpa gejala, hipotiroid, hingga tirotoksikosis. Di perlukan pemantauan pengobatan jangka panjang karena eliminasi amiodaron yang memanjang dan waktu paruh yang terkait dengan komplikasinya. Kata Kunci: amiodaron, gangguan tiroid, hipotiroid, tirotoksikosis  AbstractAmiodarone is an effective anti arrhytmic agent to control the rhytm of life threatening arrhytmia but will causevarious side effects. Thyroid dysfunction is not uncommon during amiodarone therapy and is caused by iodide excess and inhibition of deiodinase activity. Amiodarone induced thyroid dysfunction and it varies from asymptomatic variation in thyroid function to clinically hypothyroidism and thyrotoxicosis. Amiodarone should be monitored due to its prolong elimination and half life which is associated with its complication. Keywords: amiodarone, hypothyroidism, thyroid disorder, thyrotoxicosis
Co-Authors David Susanto Riki Tenggara