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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Pharmaciana: Jurnal Kefarmasian
Wiwit Ade Fidiawati
Department Of Pathology Anatomy, Faculty Of Medicine, Universitas Riau
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Public Health

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Gambaran Histopatologi Pankreas Tikus Putih (Rattus norvegicus) Pasca Perlakuan Iskemia-Reperfusi Ginjal Elva Rosiana; Wiwit Ade Fidiawati; Darmawi Darmawi
Jurnal Ilmu Kedokteran Vol 13, No 1 (2019): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (210.415 KB) | DOI: 10.26891/JIK.v13i1.2019.58-66

Abstract

Ischemic-reperfusion injury is defined by a condition of hypoperfusion in the spesific organ followed by reperfusion (reoxygenation) inducing tissue damage. Tissue damage produces reactive oxygen species (ROS) leading to oxidative stress condition. Oxidative stress mediate the lipid peroxidation reactions, harm the cell and finally facilitate the cell death. The aim of this study was to evaluate the histopathologic feature of white rat’s pancreas post renal ischemiareperfusion. This study was an experimental laboratory research with post-test-only control group design including 20 male white rats. Rats were divided into 5 groups, control, treatment 1 (45 minutes ischemia), treatment 2 (45 minutes ischemia followed by 1 hour reperfusion), treatment 3 (45 minutes ischemia followed by 2 hours reperfusion) and treatment 4 (45 minutes ischemia followed by24 hours reperfusion). We found the change of the histopathological characteristics of white rat’s pancreas in term of edema, leukocyte infiltration and vacuolization.
Repurposing drugs in endometrial cancer using genomic variants database Darmawi Darmawi; Donel S; Wiwin Suhandri; Winarto Winarto; Wirawan Adikusuma; Lalu Muhammad Irham; Wiwit Ade Fidiawati; Renardy Reza Razali; Auren Nathania; Leina Putri Zahra
Pharmaciana Vol 13, No 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.27201

Abstract

Endometrial cancer (EC) is the fourth most frequent gynecological cancers, and its incidence and mortality rates have increased over the last decade. Cytotoxic therapy with carboplatin and paclitaxel is the recommended first-line treatment for EC patients. However, the options for following therapy are limited. The latest advances in molecular studies have uncovered the nature of genetic alterations in EC, compelling methods for further research into the treatment of EC since they may disclose to tailored pharmacological therapy. The aim of this study to identify novel drug candidates in treating EC using genomics variants and biological pathway. The genomic variants of  EC were downloaded from cBioportal database. We established connection between the biological EC risk genes from cBioportal database and the DrugBank database. Finally, we used Connectivity Map (CMap) analysis to identify possible drugs whose mechanisms coincided with therapeutic targets and rank them based on the scoring system. We identified novel potential candidate drugs for EC, they are Bosutinib and Nilutamide which exhibit robust scores in the CMap analysis compare to paclitaxel. We also discovered BCR-ABL1 and AR as potential biomarker-driven therapy in EC. This study demonstrates the possibility of using genetic network analysis combined with bioinformatics to repurpose drugs for the treatment of EC. Further study will investigate the mechanisms of using BCR-ABL1 and AR targeting in the treatment of EC.
Co-Authors Auren Nathania Darmawi Darmawi Donel S Elva Rosiana Lalu Muhammad Irham Leina Putri Zahra Renardy Reza Razali Winarto Winarto Wirawan Adikusuma Wiwin Suhandri