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Yulia Margaretta Sari
Division Of Urogynecology And Reconstruction, Department Of Obstetrics And Gynecology, Faculty Of Medicine, Andalas University, Padang, West Sumatra, Indonesia
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Nursing Public Health

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PERBANDINGAN KEJADIAN KEHAMILAN PREEKLAMPSIA BERDASARKAN KOMPONEN METABOLIK Yulia Margaretta Sari; Joserizal Serudji; Rizanda Machmud
Andalas Obstetrics And Gynecology Journal Vol 3, No 2 (2019)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.3.2.116-129.2019

Abstract

In preeclampsia occurring carbohydrate and fat metabolism disorders. Components of the metabolic syndrome such as insulin resistance, obesity, and dyslipidemia contributes to the occurrence of preeclampsia. This was an obser-vational analytic study with Kohort design and has been performed in Obgyn Department of M. Djamil Hospital Padang, primary health care in Koto Berapak, Private Practice Midwive in Lintau from July 2013 to May 2014. 60 samples of second trimester of pregnancy with positive Roll over test. Each subject was examined BMI, fasting blood glucose, LDL, HDL, triglycerides, and insulin levels. Then divided into two groups, positive metabolic components group and negative metabolic components group. Statistical analysis to assess significance using the unpaired t test and chi square on SPSS 18.0 for windows. There was no significant association between metabolic components and preeclampsia (p> 0.05). Other metabolic components such as HDL level and insulin resistance were not statistically significant with preeclampsia (p> 0.05). HOMA IR examination also showed no significant association with the in-cidence of preeclampsia. However, the subgroup analysis showed a mean insulin levels higher in preeclampsia patients compared with normal pregnancies (p <0.05). BMI showed a significant association with preeclampsia (p <0.05). subgroup analysis showed a mean insulin levels higher in preeclampsia patients compared with normal pregnancies (p <0.05). BMI showed a significant association with preeclampsia (p <0.05). subgroup analysis showed a mean insulin levels higher in preeclampsia patients compared with normal pregnancies (p <0.05). BMI showed a significant association with preeclampsia (p <0.05).Keywords: Preeclampsia, metabolic syndrome, fasting blood glucose, LDL, HDL, triglycerides, HOMA-IR, BMI
A Case Report: Vesico Vaginal Fistula Rezi Amalia; Yulia Margaretta Sari`
Andalas Obstetrics And Gynecology Journal Vol. 6 No. 2 (2022)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.6.2.209-213.2022

Abstract

Background: Vesica vaginal fistula is a part of urogenital fistula wich condition that present fistula between bladder and vagina and make urine mold through vagina. Case Report: Nullipara woman, 48 years old, admitted with complaining mold of urine from vagina since ten months ago after seven days having surgery procedure. Complaint appeared seven days after hysterctomi procedure as indication of uterine myoma. The vital signs are normal. On Per Speculum examination, clearly see there are fluids on the posterior fornix. Methylene blue test show result one fistula is at the top anterior of vagina, 6 cm proximal from hymenal ring about 1-1.5 cm. The patient underwent fistulorraphy with a vaginal approach using the futh mayo technique Discussion: Vesica vaginal fistula usually occur in the development country. Predisposition factors of it caused by hysterectomy procedure, besides trauma during labor and complications of pelvic surgery may also too. Physical and additional specific examination conventionally or minimally invasive like cystoscopy, cystography with contrast can obtain diagnosis, determine the location, size and number of fistula. Surgery is the mainstay therapy for urogenital fistula through trans vaginal or trans abdomen. Approaching depends on knowledge, experience and collaboration with other experts if needed. Surgery is the mainstay therapy for urogenital fistula through trans vaginal or trans abdomen. Approaching depends on knowledge, experience and collaboration with other experts if needed. Surgery is the mainstay therapy for urogenital fistula through trans vaginal or trans abdomen. Approaching depends on knowledge, experience and collaboration with other experts if needed.
Skene Duct Cyst in Childhood: A Case Report Agung Wijaya Kusuma; Bobby Indra Utama; Yulia Margaretta Sari
Andalas Obstetrics And Gynecology Journal Vol. 7 No. 2 (2023)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.7.2.446-452.2023

Abstract

Introduction. Vaginal cysts are uncommon and may be either congenital or acquired. the most common vaginal cysts is a urothelial cyst or a paraurethral cyst. With an incidence of 1 in every 2000–7000 live births, paraurethral cysts are an uncommon cause of interlabial mass in newborns and account for less than 0.5 per cent of all congenital urinary system anomalies. Study Purpose. This report describes a rare Vaginal cyst in a child at the posterior vaginal wall.. Results.this is a case report study about a girl 1-year-8-months old with vaginal cyst since the age of 2 months. Physical examination and ultrasound finding revealed a cystic mass size 3x3x1 cm in posterolateral of the right vaginal wall extended to right periurethral. Management of this case was extirpation of the vaginal cyst.Conclusion. A vaginal cyst is an uncommon case in a child. Vaginal cysts have several possible etiologies, such as possibly embryological origin, ectopic inclusion tissue or possibly due to urological abnormalities. Diagnosis requires a thorough understanding of diagnostic possibilities and a systematic evaluation. This patient has been treated with surgical excision due to a high success rate.
Pelvic Floor Distress Inventory (PFDI)-20 Score In Patients With Pelvic Organ Prolaps (POP) Yulia Margaretta Sari; Mila Permata Sari
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 2 (2024)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.2.693-702.2024

Abstract

Background :Pelvic organ prolapse (POP) is a common and benign condition in women. It was the fall of one or more components of the vagina and uterus, which allows surrounding organs to herniate into the vaginal area, a disease known as cystocele, rectocele, or enterocele. The PFDI-20 score has been used to evaluate symptoms and quality of life in all POP patients. Objectives : To analyze the PFDI-20 score in patients with POP. Method : An observational study involving POP patients was undertaken at RSUP Dr. M. Djamil Padang from December 2023 to January 2024. The variables include demographic information (age, parity, obstetric and gynecological history) gathered from medical records, as well as complaints and POP symptoms obtained through an interview using the Indonesian PFDI-20 score. Data was analyzed univariately and bivariately. Statistical significance was set at p<0.05, and statistical analyzes were conducted using Kruskal-Wallis. The statistical program used for the analysis was SPSS 25.0. Results : Twenty-eight ladies participated. Their average age was 64.43 years (SD=10.49), parity number was 4.5 (SD=2.2), and PDFI-20 score was 136.61 (SD=54.21). In terms of POP, 53.6% (15) were IV. In terms of prolapse type, all patients had uterine prolapses, with the majority also having cystocele and rectocele (96.4%). Total vaginal hysterectomy (TVH) was performed in 82.1% (23), with over half of the patients undergoing anterior colporrhaphy (AC), posterior colpoperineorrhaphy, or colpocleisis. The majority of the complaints concerned inactive sexual activity (92.0%) and frequency (64.3%). The bivariate analysis with Kruskal Wallis test revealed no statistically significant relationships between PDFI-20 score and degree of POP (p<0.05). Conclusion : Although we were unable to identify a significant correlation, the PFDI-20 score was demonstrated to be a reliable tool for assessing symptoms and quality of life in all POP patients.
Obstructed Hemivagina and Ipsilateral Renal Agenesis (OHVIRA) Syndrome: A Rare Case Report Ega Atista; Yulia Margaretta Sari
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.1.163-169.2026

Abstract

Introduction: The Herlyn-Werner-Wunderlich (HWW) syndrome, also known as obstructed hemivagina and ipsilateral renal agenesis (OHVIRA), is a rare form of Mullerian Duct Anomalies (MDA). The patient with OHVIRA syndrome has dysmenorrhea, abdominal pain, and a lump in the belly. Although the exact cause and pathology of OHVIRA syndrome are unknown, early diagnosis and treatment can reduce acute symptoms and preserve normal fertility. Case Report: This article reports a case of 15 a 15-year-old woman who complained of foul mucopurulent discharge. Ultrasound finding uterus didelphys, right obstructed hemivagina with resultant pyocolpos, and suspected of right renal agenesis. The patient was diagnosed with OHVIRA syndrome. The patient underwent vaginal septal resection, and the pyocolpos was drained. Discussion: Intraoperatively, a completely obstructed longitudinal vaginal septum was identified on the right hemivagina, with purulent fluid consistent with pyocolpos. After septal resection, adequate drainage was achieved and communication between both hemivaginas was established. Postoperatively, the patient showed clinical improvement, with resolution of vaginal discharge and relief of vaginal obstruction. No intraoperative or immediate postoperative complications were observed. During short-term follow-up, the patient remained asymptomatic, with no evidence of recurrent obstruction or infection. Conclusion: This case highlights several important aspects of OHVIRA syndrome, including its atypical postpartum presentation, diagnostic challenges, and unpredictable reproductive outcomes. Ultrasonography plays a key role in early detection. Vaginal septal resection and drainage are effective in relieving symptoms and preventing complications. Reporting this rare presentation contributes to improved awareness and timely management of OHVIRA syndrome in adolescents.
The Role of Transforming Growth Factor Beta (TGF-β) in Pelvic Organ Prolapse : A Systematic Review Yulia Margaretta Sari; Bobby Indra Utama; Zelly Dia Rofinda; Aisyah Elliyanti
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.1.58-69.2026

Abstract

Introduction: Pelvic organ prolapse (POP) is a gynaecological disorder with a rising prevalence, significantly affecting quality of life. While the pathogenesis of POP is multifactorial, alterations in the extracellular matrix (ECM) have been implicated, particularly the role of transforming growth factor-beta (TGF-β) in ECM remodelling. However, the precise relationship between TGF-β and POP remains unclear. Methods: A systematic review was conducted following PRISMA guidelines. Relevant studies were identified from PubMed, Scopus, Web of Science, and the Cochrane Library. Inclusion criteria focused on studies investigating TGF-β expression in women with POP. Data extraction included study design, patient demographics, TGF-β detection methods, and key findings. Results: Analysis of nine studies revealed mixed findings. Four studies reported a significant reduction in TGF-β1 expression in POP patients, suggesting impaired ECM regulation via the TGF-β1/Smad3 pathway. Three studies found no significant differences in TGF-β levels between POP and control groups, while one study linked increased TGF-β1 levels to severe prolapse, possibly as a compensatory response. Variations in methodology, sample size, and patient characteristics contributed to inconsistencies across studies. Conclusion: Current evidence suggests that TGF-β1 plays a role in POP pathogenesis, with lower levels potentially weakening ECM integrity and higher levels in advanced cases reflecting a failed reparative response. Further research is needed to explore TGF-β interactions with other biomarkers and assess its potential as a therapeutic target.
Treatment of Prepubertal Labial Adhesion: A Case Report Ibnuzaer Khalilullah; Bobby Indra Utama; Yulia Margaretta Sari
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.1.179-186.2026

Abstract

Introduction : Labial adhesion is a condition in which the labia minora adhere to each other, either partially or completely, and is most commonly observed in prepubertal girls. The highest incidence typically occurs between the ages of 3 months and 6 years, a period during which lower estrogen levels make the vulvar mucosa more susceptible to irritation and adhesion. Objective : To report and discuss a rare case of labial adhesion on prepubertal. Methods : A prepubertal girl diagnose with labial adhesion at Dr. M. Djamil Central Hospital was reported and discuss the management. Result : A four-year-old girl was referred to the outpatient urogynecology clinic by a network hospital for labial adhesion. Upon general assessment, the child's development appeared appropriate for her age. Her medical history did not reveal any significant illnesses, surgical procedures, or history of sexual abuse, and her general physical examination was normal. Upon inspection, the labia majora were normal, but he labia minora appeared fused with a 0.2 cm gap at the proximal area of the adhesion. The adhesions appear thick and non-transparent For this patient, we decided to proceed with excision of the labial area without first attempting estrogen therapy. Seven days post-operation, the patient returned for a follow-up visit in good condition. The surgical wound was dry, urination was normal, and the examination showed a normal vaginal opening. Conclusion: From this case report, we conclude that for long-standing labial adhesion characterized by tissue thickening, labial excision is the appropriate and effective treatment option.
Differences in Pelvic Floor Muscle Strength Before and After Normal Delivery in Patients Who Give Birth in The Working Area of The Padang City Public Health Center Muhammad Al Fath; Yulia Margaretta Sari; Firdawati Firdawati; Yusrawati Yusrawati; Bobby Indra Utama; Puja Agung Antonius
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 2 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.2.282-290.2026

Abstract

Background: Vaginal delivery can cause physiological changes in the pelvic floor muscles and increase the risk of dysfunction such as urinary incontinence or pelvic organ prolapse. However, the extent to which uncomplicated vaginal delivery affects pelvic floor muscle strength is unknown, especially in the Padang City Community Health Center (Puskesmas) area. Objective: To determine differences in pelvic floor muscle strength before and after vaginal delivery in patients who gave birth in the Padang City Community Health Center (Puskesmas) area. Methods: This was a prospective cohort study with 30 primigravida respondents who met the inclusion criteria. Muscle strength was measured using perineometry in the final trimester and 3 months postpartum. Data were analyzed using a paired t-test (α = 5%). Results: The average age of respondents was 28.27 years. Statistical tests showed no significant difference in pelvic floor muscle strength before and after delivery (p = 0.792), indicating that postpartum strength does not affect pre-delivery strength. Conclusion: Uncomplicated vaginal delivery does not significantly affect pelvic floor muscle strength. Decreased strength may be influenced by other factors such as obstetric trauma, birth weight, and exercise during pregnancy. Longer-term follow-up studies are needed for a more comprehensive understanding.
Co-Authors Agung Wijaya Kusuma Aisyah Elliyanti Antonius, Puja Agung Bobby Indra Utama Dia Rofinda, Zelly Dia Ega Atista Firdawati Firdawati Ibnuzaer Khalilullah Mila Permata Sari Muhammad Al Fath Rezi Amalia Rizanda Machmud Yusrawati Yusrawati