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Cathelicidin, vitamin D3 dan imunitas terhadap tuberkulosis Yunita Arliny; Maryatun Hasan
Jurnal Kedokteran Syiah Kuala Vol 20, No 3 (2020): Volume 20 Nomor 3 Desember 2020
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v20i3.18610

Abstrak. Tuberkulosis (TB) merupakan salah satu penyakit infeksi yang menjadi masalah di dunia. Risiko untuk mendapatkan infeksi TB dipengaruhi oleh imunitas alamiah melawan mikobakteria. Peptida antimikroba merupakan salah satu barrier pertahanan alamiah. Cathelicidin adalah suatu peptida anti mikroba yang berperan pada proses imunitas terhadap TB. Cathelicidin Leusin Leusin-37 (LL-37) merupakan satu-satunya cathelicidin yang ada pada manusia dan dapat diekspresikan dari beberapa sel temasuk sel imun. Inducer Cathelicidin yang paling poten adalah 1,25-dihydroxyvitamin D3 yang merupakan bentuk aktif vitamin D 25(OH)D3. Tinjauan pustaka ini membahas tentang cathelicidin, vitamin D3 dam peranannya pada imunitas terhadap TB.Kata kunci: Cathelicidin, 1,25-dihydroxyvitamin D3, vitamin D 25(OH)2D3, imunitas, TuberkulosisAbstract. Tuberculosis is one of the most important infectious diseases worldwide. The susceptibility to this disease depends to great extent on the innate immune response against mycobacteria. Antimicrobial peptides are one of the natural defense barriers. Cathelicidin Leucine Leucine-37 (LL-37) is the only cathelicidin present in humans and synthesized by several cells including immune cells. The most effective inducer of Cathelicidin is 1,25-dihydroxyvitamin D3 (1,25(OH)2 D3), which is an active form of vitamin D 25(OH)D3. This review discusses cathelicidin, vitamin D3 and its role in immunity against TBKeywords: Cathelicidin, 1,25-dihydroxyvitamin D3, vitamin D 25(OH)D3, immunity, Tuberkulosis

SINDROM METABOLIK PADA PENYAKIT PARU OBSTRUKTIF KRONIK Yunita Arliny
Jurnal Kedokteran Syiah Kuala Vol 12, No 2 (2012): Volume 12 Nomor 2 Agustus 2012
Publisher : Universitas Syiah Kuala

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Abstrak. Penyakit paru obstruktif kronik sering dikaitkan dengan beberapa penyakit seperti penyakit jantung, osteoporosis, diabetes dan sindrom metabolik. Penyakit jantung dan kanker paru-paru adalah penyebab utama kematian pada pasien dengan COPD. Sindrom metabolik adalah kumpulan dari beberapa komponen yang terkait dengan risiko kejadian kardiovaskular dalam bentuk lingkar pinggang meningkat, tekanan darah tinggi, dislipidemia dan peningkatan kadar glukosa darah. Berat badan pada pasien dengan PPOK memberikan prognosis yang baik, tetapi di sisi lain meningkatkan risiko penyakit kardiovaskular.Abstract. Chronic obstructive pulmonary disease is often associated with several diseases such as cardiovascular disease, osteoporosis, diabetes and metabolic syndrome. Cardiovascular disease and lung cancer is the leading cause of death in patients with COPD. Metabolic syndrome is a collection of some of the components associated with the risk of Cardiovascular events in the form of increased waist circumference, elevated blood pressure, dyslipidemia, and elevated levels of blood glucose. Weight gain in patients with COPD provide a good prognosis but on the other hand increases the risk for cardiovascular disease.

TUBERKULOSIS DAN DIABETES MELLITUS IMPLIKASI KLINIS DUA EPIDEMIK Yunita arliny
Jurnal Kedokteran Syiah Kuala Vol 15, No 1 (2015): Volume 15 Nomor 1 April 2015
Publisher : Universitas Syiah Kuala

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Hubungan antara Tuberkulosis (TB) dan diabetes mellitus (DM) telah dikenal dalam waktu lama. Dalam beberap decade insidens TB telah menurun dinegara-negara perpenghasilan tinggi akan tetapi insidens tetap tinggi di negara-negara dengan taraf ekonomi dan gizi yang masih buruk serta memiliki insidens HIV yang tinggi. Dalam kondisi yang sama prevalens DM juga menunjukkan peningkatan secara global. Penelitian menunjukkan bahwa DM merupakan faktor risiko yang penting bagi TB dan dapat mempengaruhi klinis serta respons pengobatan serta DM merupakan risiko timbulnya TB resisten obat (MDR TB). Tinjauan pustaka ini mengulas tentang peranan DM terhadap TB dari segi klinis, respons terapi serta faktor yang terkait dengan terapi pada TB dengan DM.

PENGUKURAN KADAR FIBRINOGEN SEBAGAI PETANDA INFLAMASI SISTEMIK PADA PASIEN PENYAKIT PARU OBSTRUKTIF KRONIK Yunita Arliny
Jurnal Kedokteran Syiah Kuala Vol 12, No 1 (2012): Volume 12 Nomor 1 April 2012
Publisher : Universitas Syiah Kuala

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AbstrakPendahuluan: peradangan sistemik adalah penanda morbiditas dan mortalitas yang signifikan pada pasien dengan COPD. Fibrinogen merupakan salah satu protein fase akut yang dapat digunakan sebagai penanda inflamasi sistemik dan sindrom metabolik. Penelitian ini dilakukan untuk mengevaluasi kadar fibrinogen pada pasien PPOK stabil.Metode: Dalam studi cross sectional observasional, fourthy sepertiga pasien PPOK stabil kami mengukur kadar fibrinogen plasma tersebut.Hasil: Ada 43 pasien PPOK stabil. Rerata usia pada pasien PPOK stabil adalah 63,28 ± 5,595 tahun, FEV1 1238,14 ± 481,3, 54,30 ± 13,9% diprediksi. Tingkat fibrinogen meningkat (rata-rata 364,51 ± 70,09 mg / dl). Tingkat fibrinogen yang berkaitan dengan prediksi FEV1 (r = -, 312, p 0,05) dan frekuensi eksaserbasi.Kesimpulan: Studi menemukan bahwa tingkat fibrinogen meningkat pada pasien PPOK stabil. AbstractIntroduction: Systemic inflammation is relevant extrapulmonary markers of morbidity and mortality in patients with COPD. Fibrinogen is one of acute phase protein that can be used as marker of systemic inflammation and metabolic syndrome. This study was undertaken to evaluate the relations fibrinogen level in stable COPD patients.Methods: In observasional cross sectional study, fourthy-third stable COPD patients we measured the plasma fibrinogen levels.Results:There were 43 stable COPD patients. The mean of age in stable COPD patients was 63.28±5.595 years, FEV1 1238,14±481,3, 54,30±13,9% predicted. Fibrinogen level was increased (mean 364,51±70,09 mg/dl). Fibrinogen level were related to predicted FEV1 (r=-,312;p0,05) and frequency of exacerbations.Conclusion: Study found that fibrinogen level was increased in stable COPD patients.

Neutrophil To Lymphocyte Ratio as A Marker of COVID-19 Disease Severity in Banda Aceh Devi Efrina; Herry Priyanto; Novita Andayani; Yunita Arliny; Budi Yanti
Jurnal Respirologi Indonesia Vol 41, No 4 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i4.207

Background: Patients with severe COVID-19 always coincide with high mortality rate, meanwhile, inflammatory immunity parameters in COVID-19 infection such as Neutrophil to Lymphocyte Ratio (NLR) reflect the infection progress. These are used by clinicians for early identification of patients at high risk or to determine when it is a serious disease. This study aims to determine the effectiveness of NLR as a marker of COVID-19 pneumonia severity.Method: This study was conducted using a retrospective cross-sectional analytical design at the Regional General Hospital of DR. Zainoel Abidin Banda Aceh from June to September 2020. Patients' demographic characteristics, comorbidities, clinical manifestations of COVID-19 infection, chest x rays, examination of blood samples at admissions such as leukocytes, lymphocytes, neutrophils and NLR were extracted from medical record data. The patients were divided into four groups according to the disease severity, namely mild, moderate, severe and critical.Result: A total of 105 medical records were collected for COVID19 patients, meanwhile, 51 to 70 years was the largest age group (60.8%) with twice male than female. Moreover, fever, cough, shortness of breath and weakness are the most common symptoms found in treated patients while almost two-thirds of the patients have bilateral pneumonia. Generally, the levels of leukocytes, neutrophils, NLR were found to increase while the levels of lymphocytes decreased, in addition, more than half of the COVID19 patients were severe. There was a strong relationship between an increase in NLR levels and COVID-19 disease severity (95% CI, α: 0.05, p = 0.001)Conclusion: Based on the results, NLR is applicable as an early inflammatory marker which reflects severe and critical COVID19 infection and also suitable as an objective basis for early identification and management of severe COVID-19 pneumonia.

Specific levels of calcidiol, calcitriol, cathelicidin and interferon gamma in diabetic patients with TB infection in Jakarta, Indonesia; Case control study Yunita Arliny; Dewi Behtri Yanifitri; Budi Yanti; Diennisa Mursalin
Jurnal Respirologi Indonesia Vol 41, No 4 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i4.221

Vitamin D plays a role in regulating the immune system via Vitamin D receptors, expressed by T-helper cells (Th). Cathelicidin LL-37 is an antimicrobial peptide that acts as the primary barrier against the Mycobacterium tuberculosis bacterial infection, which is induced by calcitriol, the active form of Vitamin D3. Interferon gamma (IFN-γ) is a cytokine released by Th-1 cells, and is essential for the elimination of M. tuberculosis. This study aims to determine the state of, and correlation between, calcidiol, calcitriol, cathelicidin and IFN-γ levels, as well as other clinical factors among patients with Type 2 Diabetes Mellitus (T2DM) with active TB coinfection. Further analysis is also performed to study the differences between T2DM patients with active tuberculosis, latent TB and without TB infection.

Immunological Aspects of Latent Tuberculosis Infection in Diabetes Mellitus Yunita Arliny
Jurnal Respirologi Indonesia Vol 41, No 4 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i4.219

AbstractThe interaction of diabetes mellitus (DM) with tuberculosis (TB) is currently a health concern. Diabetes mellitus is one of the main risk factors for TB infection to become latent TB and / or progress to active TB. Immune mechanisms contribute to this increased risk. The disruption of the mycobacteria recognition process, phagocyte activity and cellular activity will affect the disruption of cytokine and chemokine production. Hyperglycemia that occurs will result in delayed adaptive immune response resulting in reduced Th1, Th2, and Th17 cells as well as the cytokines produced by these cells that play a role in macrophage activation and TB inflammatory response. Understanding of the immune mechanisms that underlie the sensitivity of DM to TB infection, especially latent TB, will facilitate the implementation of strategies in screening and therapy to deal with the double burden of both diseases. The purpose of this literature study focuses on the relationship of DM with latent TB infection in terms of immunology.

Endobronchial Tuberculosis: Diagnosis and Treatment Approach Yunita Arliny; Diennisa Shafira Mursalin
Respiratory Science Vol. 2 No. 1 (2021): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i1.24

Endobronchial tuberculosis (EBTB) is defined as tuberculosis (TB)infection of the tracheobronchial tract. Tracheal and bronchial involvement from TB infection was first reported by Morten in 1698. Endobronchial tuberculosis is a form of TB that is difficult to diagnose because the lesions are frequently undetectable by sputum examination and chest X-ray alone. Endobronchial tuberculosis is present in 10-40% of active TB patients and more than 90% of cases are accompanied by bronchial stenosis of various degrees. The main goal of therapy in active EBTB is to eradicate Mycobacterium tuberculosis in the tracheobronchial tract and further prevent stenosis. Complications of EBTB apart from airway stenosis are atelectasis, haemoptysis and shortness of breath accompanied by wheezing even after administration of anti-tuberculosis drugs (ATD).

Peran Suplementasi Mikronutrient Dalam Tatalaksana COVID 19 Yunita Arliny
Jurnal Kedokteran Syiah Kuala Vol 22, No 1 (2022): Volume 22 Nomor 1 Maret 2022
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v22i1.21968

Penyembuhan Infeksi COVID-19 bergantung pada sistem imun. Sistem imun yang baik dianggap memegang peranan penting untuk melindungi tubuh terhadap keparahan gejala klinis yang terjadi. Telah diketahui bahwa selama masa infeksi akan mengakibatkan peningkatan kebutuhan energi sehingga dibutuhkan asupan makronutrient yaitu karbohidrat, lemak dan protein yang cukup untuk dapat mengaktifkan sistem imun dengan baik. Mikronutrient berperan dalam rangkaian respon imun terhadap berbagai mikroorganisme termasuk infeksi virus, mulai dari interaksi awal host-virus, aktivasi imun alami hingga adaptif. Imunitas yang sehat memerlukan keterlibatan beberapa mikronutriet, yang tidak dapat bekerja jika hanya terpenuhi satu jenis nutrient saja. Beberapa mikronutrient tersebut adalah vitamin A, C, D, B6, B12, Besi (Fe), Zinc (Zn), selenium (Se).

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