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DISTRIBUSI GAMBARAN HISTOPATOLOGI PASIEN KANKER SERVIKS UTERI DI RSUD DR. ZAINOEL ABIDIN BANDA ACEH Fajriah Fajriah; Riska Apriliana
Jurnal Kedokteran Syiah Kuala Vol 13, No 1 (2013): Volume 13 Nomor 1 April 2013
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v13i1.3425

Abstract

Abstrak. Kanker serviks masih merupakan penyebab kematian kedua tersering pada wanita diseluruh dunia dan menempati posisi tertinggi di negara berkembang. Tujuan penelitian ini adalah untuk mengetahui distribusi pasien kanker serviks di RSUD dr. Zainoel Abidin Banda Aceh berdasarkan usia, paritas, stadium klinik, dan gambaran histopatologi. Jenis penelitian ini adalah penelitian deskriptif. Data diambil dengan melihat rekam medis pasien kanker serviks. Sampel penelitian adalah pasien kanker serviks yang berobat dan di rawat inap di RSUD dr. Zainoel Abidin Banda Aceh periode 1 Januari 2010 – 30 Juni 2012. Subjek penelitian berjumlah 22 pasien. Hasil penelitian ini menunjukkan bahwa distribusi frekuensi pasien kanker serviks paling tinggi pada usia 40 tahun (81,8%), memiliki riwayat persalinan ≥ 5 kali (59,1%), stadium lanjut (81,8%), dan jenis karsinoma skuamosa (77,3%), jenis adenokarsinoma (22,7%). Penelitian ini juga menunjukkan bahwa kanker serviks jenis karsinoma skuamosa paling banyak ditemukan pada pasien berusia 40 tahun (68,2%) dan pasien dengan riwayat persalinan ≥ 5 kali (45,5%), dan kasus stadium lanjut paling banyak ditemukan pada pasien berusia 40 tahun (63,6%) dan pasien dengan paritas ≥ 5 kali (50%). Kanker serviks paling banyak ditemukan pada kelompok usia 40 tahun, memiliki riwayat persalinan ≥ 5 kali, stadium lanjut, dan jenis karsinoma skuamosa. Abstract. The cervical cancer is still being the second most common cause of death for a women in worldwide and becoming the highest position in the developing country. The aim of this study was to determine the distribution of cervical cancer patients at RSUD dr. Zainoel Abidin Banda Aceh based on age, parity, clinical stadium, and histopathology. This is a descriptive study. All supporting data was collected from cervical cancer patients medical records. The sample were cervical cancer patienst hospitalized at RSUD dr. Zainoel Abidin Banda Aceh from January 1st, 2010 to June 30th, 2012. Total of this study subject is 22 patients. The results of this study indicated that the frequency and distribution of the highest cervical cancer patients by age 40 was 81,8%, delivery history ≥ 5 times was 59,1%, advanced stage was 81,8%, and squamous carcinoma type was 77,3%., adenocarcinoma type (22,7%).This study also showed that cervical cancer with squamous carcinoma type most commonly found in patients 40 (68,2%), and patients with delivery history ≥ 5 times (45,5%), and advanced stadium most found in patients age 40 (63,6%) and patient with delivery history  ≥ 5 times (50%). Cervical cancer is the most prevalent in the age group 40, delivery history ≥ 5 times, advanced stadium and squamous carcinoma type.
PENGARUH TORSIO TESTIS TERHADAP GANGGUAN PROSES SPERMATOGENESIS PADA TESTIS TIKUS (Rattus norvegicus) Nora Adliyanti Basar; Dahril Dahril; Tita Menawati; Fajriah Fajriah
Jurnal Kedokteran Syiah Kuala Vol 17, No 2 (2017): Volume 17 Nomor 2 Agustus 2017
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v17i2.8987

Abstract

Abstrak. Torsio testis adalah terputarnya atau melilitnya korda spermatika, yang menyebabkan terputusnya aliran darah ke testis dan struktur jaringan di dalam skrotum. Penelitian yang bertujuan untuk mengidentifikasi efek variasi durasi waktu torsio testis terhadap proses spermatogenesis yang meliputi: jumlah sel Sertoli, spermatogonia, spermatosit primer, dan round spermatid testis Rattus norvegicus dilakukan dengan menggunakan rancangan acak lengkap (RAL) dan dibagi dalam 3 kelompok yaitu kontrol (KO) dan perlakuan (P1 dan P2). Kelompok perlakuan diinduksi torsio 360o pada testis kiri selama 4 dan 8 jam. Masing-masing kelompok terdiri dari 5 ekor tikus yang diamati langsung (efek cepat) dan 5 ekor tikus yang diamati setelah 30 hari dilakukan detorsi (efek lambat). Data dianalisa dengan metode ANOVA multifaktorial dan dilanjutkan dengan uji Tuckey HSD. Hasil penelitian menunjukkan bahwa rerata jumlah sel Sertoli pada KO: 142,00 ± 12,36; P1: 48,40 ± 8,00; P2: 35,70 ± 16,28, rerata jumlah spermatogonia KO: 975,30 ± 95,12; P1: 563,70 ± 170,44; P2: 321,10 ± 181,20, rerata jumlah spermatosit primer KO: 1307,50 ± 87,57; P1: 881,50 ± 253,65 ; P2: 505,80 ± 163,69, rerata round spermatid KO: 1237,20 ± 148,75; P1: 766,10 ± 277,68; P2: 473,00 ± 133,25. Berdasarkan hal tersebut, dapat disimpulkan bahwa torsio testis selama 4 dan 8 jam mengakibatkan perubahan jumlah sel Sertoli, spermatogonia, spermatosit primer, dan round spermatid (P0,05). Diharapkan, penanganan segera kasus torsio testis dapat menurunkan angka kerusakan testis.  (JKS 2017; 2: 83-93)Kata kunci : torsio testis, proses spermatogenesis, jumlah sel SertoliAbstract. Testicular torsion is the spermatic cord twisted, which causes the interruption of blood flow to the testicles and structures within the scrotum. The research was subjected to identify the effect of various duration of testicular torsion to spermatogenesis process include on the amount of Sertoli cells, spermatogonia, primary spermatocytes, and spermatids round of Rattus norvegicus testes. This experimental research using completely randomized design (CRD) and contains of 3 groups: control (KO) and experimental groups (P1 and P2). The experimental groups which contains 20 rats underwent 360o unilateral left testicular torsion for 4 hours (P1) and 8 hours (P2). Five rats for each groups were examined after testicular torsion induced (short term effect) besides five other remained were examined after 30 days testicular tortion repaired (long term effect). Data were analyzed using ANOVA multifactorial followed by Tuckey’s HSD test. The result showed significant differences (P0,05). Between KO: 142.00 ± 12.36; P1: 48.40 ± 8.00; and P2: 35.70 ± 16.28 in the amount of Sertoli cells, between KO: 975.30 ± 95, 12: P1: 563.70 ± 170.44; P2: 321.10 ± 181.20 in the amount of spermatogonia, between KO: 1307.50 ± 87.57; P1: 881.50 ± 253.65; P2: 505, 80 ± 163.69 in the amount of primary spermatocytes, between KO: 1237.20 ± 148.75; P1: 766.10 ± 277.68; P2: 473.00 ± 133,25 in the amount of spermatids round. Therefore, testicular torsion for 4 and 8 hours resulted in changes in the amount of Sertoli cells, spermatogonia, primary spermatocytes, and spermatids round (P0,05). Expected, the immediate treatment of cases of testicular torsion may reduce the number of testicular damage. (JKS 2017; 2: 83-93)Keywords: testicular torsion, spermatogenesis process, the amount of Sertoli cell
Co-Authors Dahril, Dahril Nora Adliyanti Basar Riska Apriliana Tita Menawati Liansyah