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All Journal Jurnal Kedokteran Syiah Kuala Pharmaciana: Jurnal Kefarmasian
Bambang Prayugo
Universitas Sumatera Utara
Health Professions Medicine & Pharmacology

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POTENSI EKSTRAK IKAN GABUS TERHADAP KESEMBUHAN LUKA DIABETES Bambang Prayugo; Muhammad Ichwan; Zulham Yamamoto
Jurnal Kedokteran Syiah Kuala Vol 21, No 2 (2021): Volume 21 Nomor 2 Agustus 2021
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v21i2.20376

Abstract

Abstrak. Luka diabetes merupakan luka kronis yang berdampak buruk bagi morbiditas, mortalitas, dan psiko-sosio-ekonomi penderita maupun keluarganya. Kondisi hiperglikemia mengakibatkan fase penyembuhan luka tidak berjalan normal. Ekstrak ikan gabus, yang dapat diberikan peroral maupun sebagai bahan kombinasi penutup luka berpotensi terhadap penyembuhan luka diabetes melalui peningkatan jumlah netrofil dan makrofag, neovaskularisasi. Selain itu, ekstrak ikan gabus meningkatkan jumlah fibroblas, deposisi kolagen, peningkatan re-epitelisasi, kekuatan regangan, dan kontraksi pada penyembuhan luka. 
Anredera cordifolia leaves extract accelerates the wound healing of normal and hyperglycemic rats Gembira Arkemo Situmorang; Zulham Yamamoto; M. Ichwan; Bambang Prayugo
Pharmaciana Vol 12, No 1 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (205.772 KB) | DOI: 10.12928/pharmaciana.v12i1.21218

Abstract

Anredera cordifolia ((Madeira vein (English) or Binahong (Indonesia language)) leaves contain ingredients that promote wound healing. This study aims to determine the effect of Madeira vein leaves ethanolic extract (MLE) on normal and hyperglycemic rat wounds. This is an experimental study using male Wistar rats aged 2-3 months, body weight between 250-300 grams induced by a single injection of streptozotocin dose 60 mg/kg BW intraperitoneally. Rats were divided into 8 groups namely normal without MLE, normal with MLE 2.5% w/v, normal with MLE 5% w/v, normal with MLE 10% w/v, hyperglycemia without MLE, hyperglycemia with MLE 2.5% w/v, hyperglycemia with MLE 5% w/v and hyperglycemia with MLE 10% w/v. Punch biopsy was used to create wounds on the skin of rats with a diameter of 8 mm after the blood glucose level measurement was higher than 200 mg/dL. MLE is applied 3 times a day for 14 days on the wounds. Wound contractions occurred in line with the length of treatment days. In normal skin, the area of the wound had decreased by 22% within three days and to 76% at 14 days after wound creation. On the 14th day of treatment, the wound area of hyperglycemic rats decreased > 60%. The largest wound contraction was found when using MLE 10% w/v. Increasing the MLE dose stimulated better wound contraction/healing than control wounds. Wound healing involves many types and products of cells. Starting with hemostasis, wound healing is followed by inflammatory and proliferative phases to form new tissue, angiogenesis, and matrix formation. The MLE content is beneficial for wound healing in normal and hyperglycemic rats. MLE plays a role in accelerating wound healing in normal and hyperglycemic rats. The MLE dose of 10% w/v provides faster wound healing than the 2.5% and 5% w/v doses.
Co-Authors Gembira Arkemo Situmorang M. Ichwan Muhammad Ichwan Yamamoto, Zulham