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All Journal Jurnal Kedokteran Syiah Kuala
Silvia Yasmin Lubis
Fakultas Kedokteran, Universitas Sumatera Utara
Health Professions Medicine & Pharmacology

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Gangguan Jantung pada Anak Penderita Talasemia Mayor Herlina Dimiati; Silvia Yasmin Lubis
Jurnal Kedokteran Syiah Kuala Vol 14, No 3 (2014): Volume 14 Nomor 3 Desember 2014
Publisher : Universitas Syiah Kuala

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Abstract

Abstrak. Talasemia Mayor (TM) memerlukan transfusi berulang secara teratur akibat sistem eritropoisis yang tidak efektif. Transfusi kronis menyebabkan penumpukan zat besi pada jantung. Kelebihan besi, peningkatan curah jantung dan faktor lain berupa mekanisme imun dan perubahan pembuluh darah dianggap sebagai faktor pemicu terjadinya gangguan jantung. Gangguan jantung merupakan penentu utama prognosis dan kelangsungan hidup pada anak penderita TM. Deteksi dini gangguan jantung noninvasif  berupa EKG, ekokardiografi serta MRI T2 star (T2*), dapat mencegah terjadinya gagal jantung dengan pemberian kelasi besi adekuat pada anak yang beresiko.Abstrak. Thalassemia Major (TM) require repeated transfusions regularly due eritropoisis system ineffective. Chronic transfusions lead to a cumulation of iron in the heart. Excess iron, increased cardiac output and other factors such as immune mechanisms and changes in the blood vessels is considered a contributing factor in the occurrence of heart problems. Heart disorders are a major determinant of prognosis and survival in children with TM. Early detection of noninvasive cardiac disorders such as ECG, echocardiography and MRI T2 star (T2 *), can prevent the occurrence of heart failure in the provision of adequate iron chelation in children who are at risk.
Co-Authors Herlina Dimiati