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Poppy Anjelisa Z. Hasibuan
Universitas Sumatera Utara
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Phytochemical Screening And Antidiabetic Test Of Ethanol Extract Of Turmeric Leaves (Curcuma domestica Val.) On Decreasing Blood Glucose Of Diabetic Rats Br Turnip, Nur Ulina M; Harahap, Urip; Hasibuan, Poppy Anjelisa Z.
International Journal of Science, Technology & Management Vol. 4 No. 4 (2023): July 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i4.866

Abstract

The turmeric plant (Curcuma domestica Val.) is a tropical plant that grows a lot on the Asian continent with is use as a food coloring and fragrance. The use of turmeric leaves by residents is only a cooking ingredient not used in large quantities. Even most of these turmeric leaves are considered waste and have minimal utilization. Turmeric leaf methanol extract can be used to lower blood glucose. Turmeric leaf extract has the potential as a valuable food source of its antioxidant components, such as total phenolic compounds and flavonoids which increase radical scavenging activity. In particular, the water extract of turmeric leaves contains high total phenolic compounds (2.741?±?0.099?mg GAE/g) and flavonoids (4.776?±?0.010?mg QCE/g). Diabetes mellitus is a metabolic disorder associated with several chronic complications, such as nephropathy, neuropathy, retinopathy and cardiomyopathy. Part of the turmeric plant leaves is reported to have the ability as an antioxidant. Antioxidant compounds can control blood glucose levels and prevent diabetes complications. This study was conducted to test the ability of turmeric leaf ethanol extract (EEDK) to reduce blood glucose levels in diabetic rats induced by nicotinamide and streptozotocin and to perform phytochemical screening to determine the compounds contained in turmeric leaves so that it becomes an alternative as a diabetes treatment and can prevent damage. or diabetic complications. The results showed that turmeric leaves contained secondary metabolites, namely flavonoids, glycosides, tannins, and triterpenoids/steroids, but there were no alkaloids or saponins. The characterization results show that the sample meets the requirements. Turmeric leaf ethanol extract doses of 400 mg/kg, 200 mg/kg, and 100 mg/kg could reduce the Blood Glucose Level of NA and STZ-induced rats from the fourth day of treatment.
Phytochemical Screening And Test For Reducing Uric Acid Levels In Male Rats After Administration Of Ethanol Extract Of The Herb Binara (Artemisia vulgaris L.) Situmorang, Novidawati Boru; Harahap, Urip; Hasibuan, Poppy Anjelisa Z.
International Journal of Science, Technology & Management Vol. 4 No. 4 (2023): July 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i4.868

Abstract

Hyperuricemia is a metabolic disease generally characterized by high uric acid levels in the blood. The general treatment strategy for hyperuricemia is to decrease uric acid production using xanthine oxidation reductase inhibitors such as allopurinol and uricosuric agents. However, the drugs showed side effects, including skin rashes, diarrhoea and liver damage. To overcome the side effects of synthetic drugs, alternatives are used, namely by researching to find plants that have activity in reducing uric acid levels. The activity of reducing uric acid levels in plants is likely due to the presence of flavonoid compounds as antioxidants. Flavonoids active in reducing uric acid levels are kaempferol through xanthine oxidase inhibitors. Quercetin also has the potential to reduce uric acid levels through inhibition of the xanthine oxidase enzyme. Binara plant (Artemisia vulgaris L.) has flavonoids, tannins, alkaloids, glycosides and saponins which have potential as antioxidants and analgesics, anti-inflammatory, immunomodulating, and hepatoprotective, through secondary metabolites of flavonoids, terpenes, and phenolic acids. The Karo people have traditionally used Binara leaves to treat wounds, diarrhoea and heartburn by chewing some of the leaves and then placing them on the wounds outside the body, such as cuts and for diarrhoea and stomach ulcers and placing them around the sick stomach. This study was conducted to know the anti-hyperuricemia effect of the Ethanol Extract of Herba Binara (Artemisia vulgaris L.) on gout rats; phytochemical screening was carried out first to determine the content of Herba Binara (Artemisia vulgaris L.) compounds. The results showed that Herb Binara fulfilled the simplicia characterization requirements and contained secondary metabolites such as alkaloids, flavonoids, tannins, glycosides, saponins and steroids. Herb Binara Ethanol Extract has been shown to reduce uric acid levels in hyperuricemia rats, with the best concentrations being 400 and 800 mg/kg body weight. This was based on significantly different results p>0.05 compared to the positive control group.
Phytochemical Screening And Antidiabetic Test Of Ethanol Extract Of Sapodilla Kecik Leaves (Manilkara kauki (L) Dubard) On Decreasing Blood Glucose Of Diabetic Rats Purba, Novandi; Harahap, Urip; Hasibuan, Poppy Anjelisa Z.
International Journal of Science, Technology & Management Vol. 4 No. 4 (2023): July 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i4.869

Abstract

The development of traditional medicine needs to be carried out so that Indonesia's natural wealth can be utilized as effectively as possible to improve people's welfare. As with diabetes, some reputable traditional herbal medicines contain antidiabetic properties. Natural antidiabetic drugs derived from compounds isolated from plants can be used as an alternative to traditional medicine for diabetes because they have potential side effects. Diabetes can be treated alternatively by using various substances, especially those containing polyphenols, such as flavonoids. Sapodilla kecik (Manilkara kauki (L.) Dubard) from the Sapotaceae family is a type of plant used in traditional medicine; leaves, roots and bark can be used to treat diarrhoea in children, seeds can be used as a febrifuge, anthelmintic, and as an antileprotic. Secondary metabolites in sapodilla kecik leaves are flavonoids, alkaloids, tannins, triterpenoids and glycosides. This research was carried out by characterizing and screening phytochemicals to determine the content of compounds in Sapodilla kecik (Manilkara kauki (L.) Dubard) and carrying out antidiabetic tests on streptozotocin-nicotinamide-induced diabetic rats. The results showed that sapodilla kecik leaves fulfilled the simplicia characterization requirements. Sapodilla leaves contain secondary metabolites such as alkaloids, flavonoids, tannins, glycosides, saponins and steroids. The ethanol extract of sapodilla kecik leaves at a dose of 500 mg/Kg BW starting from the 4th day of treatment, a dose of 250 mg/Kg BW starting on the 8th day of treatment, and a dose of 125 mg/Kg BW starting on the 12th day was able to reduce the KGD of induced diabetic rats with nicotinamide and streptozotocin.
Co-Authors Br Turnip, Nur Ulina M Novidawati Boru Situmorang Purba, Novandi Urip Harahap