Article Per Year (5 Year)
p-Index From 2020 - 2025
0
P-Index
This Author published in this journals
All Journal Jurnal Sains Materi Indonesia
Sudirman Sudirman
Pusat Teknologi Bahan Industri Nuklir (PTBIN) - BATAN Kawasan Puspiptek, Serpong 15314, Tangerang Selatan
Materials Science & Nanotechnology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
SYNTHESIS AND IMMOBILIZATION OF CAPTOPRILIN HYDROGEL POLYVINYL ALCOHOL-POLYVINYL PIRROLIDONE PREPARED BY FREEZING-THAWAND GAMMA RADIATION Erizal Erizal; Darmawan Darmawan; Sudirman Sudirman; Sudaryanto Sudaryanto
Jurnal Sains Materi Indonesia Vol 14, No 4: JULI 2013
Publisher : Center for Science & Technology of Advanced Materials - National Nuclear Energy Agency

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (251.995 KB) | DOI: 10.17146/jsmi.2013.14.4.4383

Abstract

SYNTHESIS AND IMMOBILIZATION OF CAPTOPRILIN HYDROGEL POLYVINYL ALCOHOL-POLYVINYL PIRROLIDONE PREPARED BY FREEZING-THAWAND GAMMA RADIATION. In order to apply the hydrogel as a matrix for controlled drug release, the polyvinylalcohol (PVA)-polyvinyl pirrolidone (PVP) hydrogels have been synthesized and used for immobilization of captopril. The mixture of PVA-PVP solution containing captopril were freezing and thawing followed by gamma irradiation from Co-60 with the doses of 10 kGy, 20 kGy and 30 kGy. The water absorption and gel fraction of hydrogels were measured gravimetrically. The chemical changes of hydrogels were determined using Fourier Transform Infrared (FT-IR) spectrometer. The release of captopril were monitored using Ultra Violet-Visible (UV-Vis) spectrophotometer. It was found that with increasing cycled of freeze-thawing and irradiation dose up to 30 kGy, gel fraction and water absorption of hydrogels increase. FT-IR spectra demonstrated that there was strong intermolecular crosslinking between the PVAand PVP. The release rate of captopril from hydrogel increases with increasing irradiation dose. The release pattern indicates that the captopril released in medium were with zero order during most of the release period and generally with burst effect. The results suggest that crosslinked PVA-PVP hydrogels are suitable for controlled release of drug.
SINTESIS BAHAN MAGNETIK PSEUDO BROOKITE Fe2TiO5 BERBASIS SUMBER DAYA MINERAL LOKAL Prijo Sardjono; Wisnu Ari Adi; Sudirman Sudirman
Jurnal Sains Materi Indonesia Vol 14, No 3: APRIL 2013
Publisher : Center for Science & Technology of Advanced Materials - National Nuclear Energy Agency

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (461.355 KB) | DOI: 10.17146/jsmi.2013.14.3.4416

Abstract

SINTESIS BAHAN MAGNETIK PSEUDO BROOKITE Fe2TiO5 BERBASIS SUMBER DAYA MINERAL LOKAL. Telah dilakukan sintesis dan karakterisasi bahan magnet pseudobrookite Fe2TiO5 dari sumber daya alam lokal pasir besi. Mineral pasir besi diperoleh dari pesisir pantai Banten. Pasir besi ini dipreparasi dengan teknik mechanical milling untuk memperoleh ukuran partikel yang kecil. Kemudian pasir besi hasil milling dilakukan leaching dan seperator magnetic untuk menghilangkan pengotor-pengotor non magnetik. Hasil pemisahan dengan separator magnetic ditambahkan TiO2 sesuai kaidah stoikiometri untuk dibuat bahan magnet pseudobrookite Fe2TiO5. Sintesis pseudobrookite Fe2TiO5 menggunakan metode reaksi padatan melalui proses mechanical milling dan di sintering pada suhu 1.000 oC selama 5 jam. Hasil refinement dari pola difraksi sinar-X menunjukkan bahwa telah terbentuk bahan magnet pseudobrookite Fe2TiO5 dengan struktur kristal orthorombik (grup ruang C m c m), parameter kisi a = 3,7233(5) Å; b = 9,774(1) Å dan c = 9,968(1) Å, α  = β = γ = 90o, volume unit sel sebesar V = 362,8(1) Å3 dan kerapatan atomik sebesar ρ = 4,178 g.cm-3. Hasil pengukuran sifat magnetik menunjukkan bahwa pseudobrookite Fe2TiO5 hasil sintesis bersifat soft magnet dengan medan koersivitas dan magnetisasi remanen berturut-turut adalah 461 Oe dan 0,2 emu/g. Disimpulkan bahwa telah berhasil dibuat bahan magnet pseudobrookite Fe2TiO5 dari bahan baku sumber daya alam lokal pasir besi
Co-Authors Darmawan Darmawan Erizal Erizal Prijo Sardjono Sudaryanto Sudaryanto Wisnu Ari Adi