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All Journal Jurnal Ilmiah Aplikasi Isotop Radiasi
Siti Nurhayati
Center for Technology of Radiation Safety and Metrology, National Nuclear Energy Agency Jalan Lebak Bulus Raya No. 49, Kotak Pos 7043 JKSKL, Jakarta 12440, Indonesia.
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Immunology & microbiology Materials Science & Nanotechnology

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Frequencies of Micronucleus in Mononucleated Cells of People Living in Takandeang Village – A High Level of Natural Radiation Area in Indonesia Sofiati Purnami; Masnelli Lubis; Suryadi Suryadi; Siti Nurhayati; Dwi Ramadhani; Mukh Syaifudin
Jurnal Ilmiah Aplikasi Isotop dan Radiasi Vol 14, No 2 (2018): Desember 2018
Publisher : BATAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (414.156 KB) | DOI: 10.17146/jair.2018.14.2.4624

Abstract

Our previous study showed that the micronucleus frequencies of Botteng Village inhabitants in Mamuju (a high background radiation area) were higher compared to control samples even though the difference was not significant. To validate our previous study result, here in this study we assessed the micronucleus frequencies in mononucleated cells of Takandeang Village inhabitants. Twenty seven healthy adult subjects from Takandeang Village and normal background radiation area were included in this study. Micronucleus numbers (MN) in 1000 mononucleated cells (MNC) were evaluated in this study. Results showed that mean MN numbers in MNC (MNMNC) of Takandeang Village inhabitants were significantly higher compared to control samples [3.96 ± 0.488 vs 1.96 ± 1.675; p<0.05]. The age and gender factors did not affect the MNMNC in all samples (p>0.05). It is possible that the high background radiation exposure received by Takandeang Village inhabitants induced not only the clastogenic but also aneugenic effect in lymphocytes. Overall our study showed that scoring of MNMNC can provide additional information in cytokinesis block micronucleus (CBMN) assay. Further study should be performed to validate this study results. The 24 hours culture time should be used in the further study to obtain more comprehensive results. 
Co-Authors Dwi Ramadhani Masnelli Lubis Mukh Syaifudin Sofiati Purnami Suryadi Suryadi