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The Effect of Olive Oil Addition into Oatmeal in Lowering Total Blood Cholesterol and LDL (Low Density Lipoprotein) in Wistar Rat Hadinata, Sebastian; Herdiman, Heddy; Tanuwijaya, Fenny
Journal of Medicine and Health Vol 1, No 3 (2016)
Publisher : Maranatha Christian University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Oat contains beta-glucan fiber and olive oil contains unsaturated fatty acids which havebeen proven to decrease blood cholesterol. This research compared the effect between acombination of oatmeal and olive oil and each food as single intake in decreasing total bloodcholesterol and LDL cholesterol. We used 25 rats (Rattus norvegicus L.), divided them into fivegroups; negative control (KN), positive control (KP), olive oil group (KMZ), oatmeal group(KBG), and combination group (KMZ+KBG). The total blood cholesterol and LDL cholesterollevels were measured after 14 days of induction and after 28 days of treatment. Data wereanalyzed using one way ANOVA, continued with LSD test with Î± = 0.05. The result showedthere were 10.85%, 8.85% and 6.60% lower in total blood cholesterol level using KMZ+KBG,KMZ and KBG respectively and 13.85%, 9.33% ,and 8.80% lower in LDL cholesterol levelusing KMZ+KBG, KMZ and KBG respectively. ANOVA test showed a significant decrease ineach treatment. LSD test showed that there was a significant difference between KMZ+KBGcompared to KBG in total blood cholesterol and LDL lowering, but did not showed significantdifference compared to KMZ.Keywords: oatmeal, olive oil, total blood cholesterol, LDL

Suplementasi Vitamin D3 Dosis Tinggi Menurunkan Kalsifikasi Tulang Femur pada Janin Mencit Maranatha, Timothy Imanuel; Herdiman, Heddy; Wargasetia, Teresa Liliana
Jurnal Kedokteran Brawijaya Vol 29, No. 3 (2017)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2017.029.03.1

Kelebihan asupan vitamin D pada mencit yang bunting dapat menyebabkan penurunan massa tulang janin. Penelitian dilakukan untuk mengetahui apakah pemberian suplementasi vitamin D3 dosis tinggi dapat mengganggu kalsifikasi tulang femur janin mencit. Metode eksperimental laboratorium dengan rancangan acak lengkap dilakukan menggunakan lima ekor mencit jantan dan lima ekor mencit (Mus musculus L.) betina galur Swiss Webster berumur 8-12 minggu. Subjek penelitian adalah lima janin mencit dari hasil perkawinan yang hidup. Mencit dibagi ke dalam lima macam perlakuan yaitu KN (kontrol negatif), perlakuan A (13 IU vitamin D3), perlakuan B (13 IU vitamin D3), perlakuan C (13 IU vitamin D3), dan perlakuan D (13 IU vitamin D3). Mencit dikawinkan, kemudian diberi suplementasi sejak usia kebuntingan 11 hari. Pada usia kebuntingan 20 hari, mencit dikorbankan kemudian dilakukan pewarnaan Alizarin Red S terhadap janin. Parameter yang diuji adalah panjang tulang femur janin mencit yang mengalami kalsifikasi setelah diberi perlakuan. Analisis data menggunakan uji Analysis of Varian (ANOVA) satu arah yang dilanjutkan dengan uji Least Significance Different (LSD) dengan Î±=0,05. Hasil menunjukkan bahwa janin mencit yang diberi vitamin D3 dosis tinggi (kelompok C dan D) memiliki panjang kalsifikasi tulang femur yang berbeda bermakna (pâ‰¤0,05) yaitu lebih pendek dibandingkan dengan kontrol negatif, kelompok A, dan kelompok B. Simpulan penelitian adalah pemberian vitamin D3 dosis tinggi menurunkan kalsifikasi tulang femur janin mencit.Kata Kunci: Janin, kalsifikasi tulang, vitamin D3

The Effect of Olive Oil Addition into Oatmeal in Lowering Total Blood Cholesterol and LDL (Low Density Lipoprotein) in Wistar Rat Sebastian Hadinata; Heddy Herdiman; Fenny Tanuwijaya
Journal of Medicine and Health Vol. 1 No. 3 (2016)
Publisher : Universitas Kristen Maranatha

Oat contains beta-glucan fiber and olive oil contains unsaturated fatty acids which havebeen proven to decrease blood cholesterol. This research compared the effect between acombination of oatmeal and olive oil and each food as single intake in decreasing total bloodcholesterol and LDL cholesterol. We used 25 rats (Rattus norvegicus L.), divided them into fivegroups; negative control (KN), positive control (KP), olive oil group (KMZ), oatmeal group(KBG), and combination group (KMZ+KBG). The total blood cholesterol and LDL cholesterollevels were measured after 14 days of induction and after 28 days of treatment. Data wereanalyzed using one way ANOVA, continued with LSD test with Î± = 0.05. The result showedthere were 10.85%, 8.85% and 6.60% lower in total blood cholesterol level using KMZ+KBG,KMZ and KBG respectively and 13.85%, 9.33% ,and 8.80% lower in LDL cholesterol levelusing KMZ+KBG, KMZ and KBG respectively. ANOVA test showed a significant decrease ineach treatment. LSD test showed that there was a significant difference between KMZ+KBGcompared to KBG in total blood cholesterol and LDL lowering, but did not showed significantdifference compared to KMZ.Keywords: oatmeal, olive oil, total blood cholesterol, LDL

Pengaruh Goji Berry (Lycium barbarum) Terhadap Kadar Glukosa Darah Puasa Dan Dua Jam Postprandial Pria Dewasa Normoglikemik Yenny Frida Setiawan; Fenny Fenny; Heddy Herdiman; Willie Japaries; Suminah Suminah
USADA NUSANTARA : Jurnal Kesehatan Tradisional Vol. 1 No. 2 (2023): Juli: USADA NUSANTARA
Publisher : Sekolah Tinggi Agama Buddha Nalanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47861/usd.v1i2.386

Background: Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia due to abnormal insulin secretion, insulin function or both. Based on World Health Organization, DM was the eighth leading cause of death in the world (2012), 43% of deaths happened at age less than 70 years. Microvascular and macrovascular complications caused by DM, long-term therapy, and side effects of therapy have greatly affected the patients’ quality of life. Hence, people have seeked many DM adjuvant therapy from herbs, one of which is goji berries [Lycium barbarum]. The Lycium barbarum polysaccharides (LBP) has been shown to have blood glucose lowering effect. Methods: This study aimed to investigate the effect of goji berries on reducing blood glucose levels. The research was conducted through pre and posttest design on fasting and two hours postprandial blood glucose levels in young adult males before and after receiving 20 g dried goji berries per day for 14 days. Statistical analysis used in this research was paired t test with α=0.05. Results: This study showed that the consumption of goji berries for 14 days did not significantly affect the fasting and two hours postprandial blood glucose levels (p>0.05) of the volunteers. Conclusion: Goji berries did not reduce fasting and two hours postprandial blood glucose levels in normoglycemic males.

The Effect of Olive Oil Addition into Oatmeal in Lowering Total Blood Cholesterol and LDL (Low Density Lipoprotein) in Wistar Rat Sebastian Hadinata; Heddy Herdiman; Fenny Tanuwijaya
Journal of Medicine and Health Vol 1 No 3 (2016)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i3.518

Oat contains beta-glucan fiber and olive oil contains unsaturated fatty acids which havebeen proven to decrease blood cholesterol. This research compared the effect between acombination of oatmeal and olive oil and each food as single intake in decreasing total bloodcholesterol and LDL cholesterol. We used 25 rats (Rattus norvegicus L.), divided them into fivegroups; negative control (KN), positive control (KP), olive oil group (KMZ), oatmeal group(KBG), and combination group (KMZ+KBG). The total blood cholesterol and LDL cholesterollevels were measured after 14 days of induction and after 28 days of treatment. Data wereanalyzed using one way ANOVA, continued with LSD test with Î± = 0.05. The result showedthere were 10.85%, 8.85% and 6.60% lower in total blood cholesterol level using KMZ+KBG,KMZ and KBG respectively and 13.85%, 9.33% ,and 8.80% lower in LDL cholesterol levelusing KMZ+KBG, KMZ and KBG respectively. ANOVA test showed a significant decrease ineach treatment. LSD test showed that there was a significant difference between KMZ+KBGcompared to KBG in total blood cholesterol and LDL lowering, but did not showed significantdifference compared to KMZ.Keywords: oatmeal, olive oil, total blood cholesterol, LDL

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