Article Per Year (5 Year)
p-Index From 2020 - 2025
0
P-Index
This Author published in this journals
All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Kimia Terapan Indonesia
Adang Hardi Gunawan
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Clearance profile of radioactive gold nanoparticle (198Au) conjugates-poliamidoamin generation 4-nimotuzumab ; potential radio-pharmaceutical theranostic agent Nurhatidjah Awaliyah Halid; Abdul Mutalib; Anung Pujiyanto; Adang Hardi Gunawan
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (581.999 KB) | DOI: 10.12928/pharmaciana.v7i2.6725

Abstract

Theranostic agents are agents that combine diagnostic and therapeutic capabilities into a single agent. The presence of conjugated cancer which is therapeutic agents such as nimotuzumab monoclonal antibodies with radioactive gold nanoparticles stabilized with Polyamidoamine Generation 4 (PAMAM G4) dendrimer can actively interact with specific cancer cells. Radioactive gold (198Au) as a radiation transmitter β (961 keV) capable for killing cancer cells and (412 keV) γ rays that give a golden image in the body, thus acting as a theranostic agent. The purpose of this study was to obtain confident results of conjugate safety by observing the constituent clearance of 198AuNP-PAMAM G4-Nimotuzumab. The result of the conjugate clearance will be the reference for the metabolic state as a new, stable and complete radiofarmaka upon reaching the desired target. This study began with the synthesis of the conjugate of 198AuNp-PAMAM G4-nimotuzumab and then tested the clirens and analyzed the results of urine and mouse feces that had been injected with conjugate. Total clearance was obtained about 47.38% of the 198AuNP-PAMAM G4-Nimotuzumab conjugates that have been excreted through urine (18.26%) and stool (29.11%.). Urine and feces were analyzed with SDS-PAGE giving the spot above the 150 kDa band and showing the conjugate molecular weight. FTIR analysis of urine and feces by showing aldehyde functional groups (C = O), alcoholic groups (O-H), amine groups (C-N), and amine groups (N-H) indicating the presence of AuNP-PAMAM G4-Nimotuzumab conjugates in urine and mouse feces. The results of urine and fecal excretion of the conjugate are still conjugate-shaped supported by SDS PAGE analysis, UV-Vis spectrophotometer absorption analysis and functional group analysis with FTIR that has been conducted.
RADIONUCLIDIC IMPURITIES IN PERTECHNETATE SOLUTION ELUTED FROM 99mTc-CHROMATOGRAPHIC GENERATOR LOADED WITH 99Mo-FISSION PRODUCT Sunarhadijoso Soenarjo; Adang Hardi Gunawan
Jurnal Kimia Terapan Indonesia Vol 7, No 1-2 (1997)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3245.144 KB) | DOI: 10.14203/jkti.v7i1-2.222

Abstract

Medical radioisotope of 99mTc was firstly produced in Indonesia through the nuclear reaction of 98Mo (n;y) 99Mo -> 99mTc. The separation of the resulting 99mTc from the postirradiated natural MoO3 was carried out by solvent extraction using methyl ethyl ketone. Instead of this method, Radioisotope Production Center (RPC) BATAN has routinely produced 99mTc-chromatographic generator loaded with 235U-flSsion-produced 99Mo to provide 99mTc. By such generator, 99mTc can be easily and repeatedly liberated in the form of pertechnetate by vacuum elution using saline solution. Some fission- produced radionuclides, however, potentially contaminate the pertechnetate fraction. Gamma spectrometric determination was carried out to evaluate the level of radionuclidic impurities contaminating 99mTc-pertechnetate solution eluted from 99mTc- chromatographic generator produced over a 10-month period in 1993 - 1994. Radioactivity yield of the resulting 99mTc was independent to the origin of the loaded 99Mo. The 99mTc-pertechnetatate fractions were frequently contaminated with 99Mo, 131I and 103Ru, but the contamination did not exceed maximum permissible level. The fluctuation of contamination level may be influenced by irradiation parameters and separation techniques applied to the production of the loaded 99Mo.
Co-Authors Abdul Mutalib Anung Pujiyanto Nur Hatidjah Awaliyah Halid Sunarhadijoso Soenarjo