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All Journal FIAT JUSTISIA: Jurnal Ilmu Hukum Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)
Yuswanto Yuswanto
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Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology

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EVALUASI TERHADAP PERDA TENTANG RETRIBUSI DAERAH KOTA BANDARLAMPUNG Yuswanto Yuswanto
Fiat Justisia: Jurnal Ilmu Hukum Vol 1 No 2 (2007)
Publisher : Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25041/fiatjustisia.v1no2.672

Abstract

Lahirnya Undang-undang No.  22 Tahun 1999 tentang Pemerintahan Daerah UU No.  25 Tahun 1999 tentang Perimbangan Keuangan Antara Pemerintah Pusat dan Daerah,  ternyata menimbulkan berbagai persoalan khususnya dalam perkembangan pajak Daerah dan terutama Retribusi Daerah.  Kedua peraturan tersebut menjadikan Daerah seakan berlomba-lomba menciptakan jenis retribusi Daerah Terbitnya Peraturan Pemerintah(PP)  No.  25 Tahun 2000 tentang Kewenangan Pemerintah Dam Kewenangan Propinsi Sebagai Daerah Otonom ternyata bukan sebagai solusi bagi perkembangan pajak daerah dan retribusi daerah.  Akibat terbitnya PP yang multitafsir ini menjadikan Daerah Kabupaten/Kota menganggap semua kewenangan yang tidak tertulis dalam PP imi merupakan kewenangan yang bagi kedua Daerah itu.  Akibatnya,  di berbagai Daerah terutama otomatis Kabupaten/Kota bermunculam Perda tentang retribusi Daerah baru yang berkaitan dengam kewenangannya yang tidak diatur dalam PP itu.  Kata Kunci Perda,  Retribusi Daerah,  Evaluasi Terhadap Perda
UJI KELARUTAN UNTUK SELEKSI FASE MINYAK, SURFAKTAN DAN KOSURFAKTAN DALAM PREPARASI SELF-NANO EMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) FUROSEMID lis Wahyuningsih; Sugiyanto Sugiyanto; Yuswanto Yuswanto; Ronny Martein
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine"
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (169.872 KB) | DOI: 10.31942/jiffk.v0i0.1351

Abstract

ABSTRACT Furosemide has a low solubility in water and leads to absorption profile this drug is highly variable after oral administration. Self-nano emulsifying drug delivery system (SNEDDS) is a drug delivery system that can be developed for furosemide to improve its absorption profile. Selection of oil phase, surfactant and cosurfactant has an important role in furosemide SNEDDS. The solubility of furosemide performed in the oil phase: oleic acid, red palm oil, and olive oil. The solubility of furosemide was also measured in a surfactant: tween 80, tween 20 and cremophor RH40 and the cosurfactant: propilenglikol (PG), polyethylene glycol (PEG) 400 and glycerol. The solubility test was performed at a temperature of 37°C and furosemide levels in the oil phase, surfactant and cosurfactant were determined by a spectrophotometer. Furosemide solubility in the oil phase of oleic acid, red palm oil, and olive oil are (158, 80 and 32) mg/mL respectively. Meanwhile, furosemide solubility in surfactant tween 80, tween 20 and cremophor RH40 are (278.889; 202.527 and 237.250) mg/mL respectively. In addition, the solubility of furosemide in a cosurfactant PG, PEG 400 and glycerol are (92.0; 1374.867 and 225.044) mg/mL respectively. This study concluded that the greatest furosemide solubility in the oil phase, surfactant and cosurfactant respectively is oleic acid, tween 80 and PEG 400. These materials can be selected as a component of furosemide SNEDDS. Key words: furosemide, SNEDDS, oil phase, surfactant, cosurfactant
Co-Authors lis Wahyuningsih Ronny Martein Sugiyanto Sugiyanto