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Afiono Agung Prasetyo
Sebelas Maret University
Biochemistry, Genetics & Molecular Biology

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Toxoplasma gondii Coinfection in HIV/AIDS Patients of Dr. Moewardi Hospital in Surakarta Irvan Raharjo; Yulia Sari; Afiono Agung Prasetyo
Nexus Biomedika Vol 4, No 2 (2015): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Coinfection of T. gondii and HIV/AIDS will result in severe clinical symptoms. Age and gender are risk factors that are often associated with the occurrence of this coinfection. This study aimed to determine the seroprevalence of T. gondii and HIV/AIDS coinfection as well as to determine its association with age and gender. Methods: Serological test, ELISA, was performed in order to determine the presence of IgM anti-Toxo and IgG anti-Toxo in 51 blood samples taken from HIV/AIDS patients at Dr. Moewardi Hospital in November 2011. Results: The positive rates of IgM anti-Toxo and IgG anti-Toxo were 25.5% (13/51) and 17.6% (9/51), respectively. IgM anti-Toxo was associated with age ? 37 years (aOR 9.34 (95% CI 1.77549.174; p = 0.008)). Unless otherwise stated, no statistical association could be drawn. Conclusions: Screening on T. gondii infection is recommended for all HIV/AIDS patients since the positivity rates of anti-Toxo antibodies were found high in these patients. Keywords: Toxoplasma gondii, HIV/AIDS coinfection
Interleukin-10 of Positive and Negative HIV RNA Patients in Dr. Moewardi General Hospital in Surakarta Emirita Wulan Pradeta; Afiono Agung Prasetyo; Yulia Sari
Nexus Biomedika Vol 4, No 2 (2015): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: HIV infection may cause imbalance of immune system and impacts on IL-10 status which has several immunological roles that may affect HIV infection itself. The aim of this study was to investigate the association between IL-10 and HIV RNA status. Methods: The IL-10 levels in the plasma samples obtained from 60 HIV patients in Dr. Moewardi General Hospital in Surakarta were analyzed by ELISA (Enzyme-Linked Immunosorbent Assay). Results: Elevated IL-10 level was found in 21.7% (13/60) samples and predominantly in positive HIV RNA (OR 2.67; 95% CI 0.40-17.96) and male (OR 1.22; 95% CI 0.36-4.17) patients. Conclusion: Elevated IL-10 level was associated with positive HIV RNA status and gender. Keywords: IL-10, HIV RNA
Co-Authors Emirita Wulan Pradeta Irvan Raharjo Yulia Sari