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Windhy Monica
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Biochemistry, Genetics & Molecular Biology

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CCR2-V64IPolymorphism in Multidrug-Resistant TuberculosisPatients in Dr. Moewardi General Hospital in Surakarta Windhy Monica; Afiono Agung Prasetyo; Marwoto .
Nexus Biomedika Vol 4, No 3 (2015): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Genetic variants of CCR2 (CC chemokine receptor type 2) are associated with susceptibility to tuberculosis (TB), however its association with Multidrug-Resistant Tuberculosis (MDR-TB) is still unknown. The aim of the present study was to find out the status of CCR2-V64I polymorphisms among MDR-TB patients in Dr. Moewardi General Hospital in Surakarta. Methods: Blood samples from 36 MDR-TB patients in Dr. Moewardi General Hospital in Surakarta were subjected to DNA isolation. The DNA was genotyped for CCR2-V64I polymorphisms by a polymerase chain reaction with sequence-specific primers (PCR-SSP). Results: The wild type (GG) was found in 21/36 (58%) samples. The heterozygous genotype (GA), homozygous genotype (AA), and A allele frequencies in the population respectively were 39%, 3%, and 22%. Conclusion: The frequency of mutant type (GA and AA) was found lower than the wild type (GG) in the population of MDR-TB patients. Keywords: CCR2-V64I, MDR-TB, Surakarta
Co-Authors Afiono Agung Prasetyo Marwoto .