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All Journal The Journal of Pure and Applied Chemistry Research
Minarti Minarti
Indonesian Institute of Sciences (LIPI)
Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology

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Structure Modification of Quinine on C-9 Hydroxyl Group via Esteriļ¬cation Reaction Teni Ernawati; Minarti Minarti; Puspa Dewi Narrij Lotulung
The Journal of Pure and Applied Chemistry Research Vol 9, No 1 (2020): Edition January-April 2020
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2020.009.01.505

Abstract

Concept the role played by modified quinine in the asymmetric hydroxyl group inspired studies of modified quinine as chiral organic that lead to drug discovery development. A simple and efficient method for C-9 alkylation and arylation of quinine derivatives was reported. Series quinine derivatives were synthesized through the esterification of the hydroxyl group of quinine. The reaction with various alkyl and aryl carbonyl chloride resulted in the series of ester quinine derivatives. The structure of quinine derivatives was characterized by IR, melting point, UV, 1H NMR, 13C NMR, LCMS.
Co-Authors Puspa Dewi Narrij Lotulung Teni Ernawati