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All Journal The Journal of Pure and Applied Chemistry Research Indonesian Journal of Pharmaceutical Science and Technology
Suman Das
BCSIR Laboratories, Chittagong, Bangladesh
Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Materials Science & Nanotechnology Medicine & Pharmacology

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Estimation of Ketorolactromithamine in Phamaceutical Samples and Biofluids by The New Validated UPLC Method Mohammad Nasir Uddin; Monir Uddin; Md. Touhidul Kabir; Suman Das
The Journal of Pure and Applied Chemistry Research Vol 6, No 2 (2017): Edition of May-August 2017
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (866.59 KB) | DOI: 10.21776/ub.jpacr.2017.006.02.318

Abstract

A new UPLC method has been described to determine ketorolac tromethamine in pharmaceutical samples and biofluids. Drug was eluted using a reversed-phase Gemini 3U, C18, 110R (150 × 4.6 mm, 3 μm) column when a mobile phase composition 90:05:05 (v/v) consisting CH3OH, CH3CN and NaH2PO4 under isocratic program.Ketorolac tromethamine was eluted at a short of time 2.02 min. Ketorolac tromethamine isolated from biofluids after liquid-phase extraction. The results were linear up to 10 µg mL-1 with the correlation coefficients greater than 0.999. The sensitivity limits, LOD and LOQ were 0.016 and 0.051 µg mL-1, respectively. The method is simple, fast and reliable with good specificity and sensitivity and will be suitable for routine analysis of ketorolac tromethamine.
Degradation Study of Ketorolactromethamine by a Validated UPLC Method Mohammad Nasir Uddin; Md. Al-Amin; Md. Nazmul Haque Mijan; Suman Das
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (577.906 KB) | DOI: 10.24198/ijpst.v6i1.16508

Abstract

UPLC stability indicating method was developed for determining ketorolac tromethamine in its degradation study at different conditions. An isocratic mobile phase composition of 60:10:30 (v/v) containing CH3OH, CH3CN and 5mM NaH2PO4 and C18 column were used at a flow rate of 0.20 mL min-1. Satisfactory retention time was found 2.13±0.05 min at 320 nm when monitored by DAD detector. Forced degradation studies of ketorolac tromethamine was also performed at the following conditions: acid and basic hydrolysis, heat (50-70°C for 1 hr), photolytic (UV and sunlight for up to 3 hr), oxidation (3% hydrogen peroxide for 1 hr). Forced degradation study revealed that ketorolac degraded significantly under thermal conditions. In 1N acid and base hydrolysis, degradation was moderately significant and comparable. It was degraded marginally in 0.1N acid-base hydrolysis which was comparable to oxidative conditions. But in photolytic condition ketorolac shows insignificant degradation. Method was also applied to pharmaceutical formulation.Keywords: UPLC, Ketorolac tromethamine, pharmaceutical formulation, Forced degradation
Co-Authors Md. Al-Amin Md. Nazmul Haque Mijan Md. Touhidul Kabir Mohammad Nasir Uddin Mohammad Nasir Uddin Monir Uddin