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All Journal The Journal of Pure and Applied Chemistry Research
Taher Sharif Ababne
Tafila Technical University, Faculty of Science , Department of Chemistry
Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology

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Synthesis, Characterization and Antifungal Activity of Some Substituted 4-thiazolidinone Derivatives Hamdan Salameh Al-Ebaisat; Taher Sharif Ababne; Tareq Mousa Al Shboul; Taghreed M. Jazzazi
The Journal of Pure and Applied Chemistry Research Vol 5, No 3 (2016)
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (768.843 KB) | DOI: 10.21776/ub.jpacr.2016.005.03.248

Abstract

A series of 4-thiazolidinone derivatives was prepared including 2- (4-phenyl)-3-(4-hydroxyphenyl)thiazolidinone-4-one (1), 2-(4-bromophenyl)-3-(4-hydroxy phenyl) thiazolidinone-4-one (2), 2-(4-chlorophenyl)-3-(4-hydroxyphenyl) thiazolidinone-4-one (3), 2-(4-methylphenyl)-3-(4-hydroxyphenyl) thiazolidinone-4-one (4),  2-(4-metoxyphenyl)-3-(4-hydroxyphenyl) thiazolidinone-4-one (5), 2-(4-nitrophenyl)-3-(4-hydroxyphenyl) thiazolidinone-4-one (6), 2,3-bis(4-hydroxyphenyl) thiazolidinone-4-one (7) and 2-(4-ethyl phenyl)-3-(4-hydroxyphenyl) thiazolidinone-4-one (8).   The chemical structures of prepared compounds have been characterized by Mass, IR, 1H-NMR, and elemental analyses. The biological activity of these compounds as fungicides was tested against three commercially known fungicides (C. albicans, patient isolate C. glabrata and C. krusei). The biological activity of compound (6) was found to be comparable to that of the commercially available fungicides.
Co-Authors Hamdan Salameh Al-Ebaisat Taghreed M. Jazzazi Tareq Mousa Al Shboul