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Hesti Riasari
Department of Pharmaceutical Biology, Indonesia School of Pharmacy , Bandung, Indonesia
Computer Science & IT Medicine & Pharmacology

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Evaluation Patch of Rhizoma Extract Kencur (Kaempferia galanga L.) as Anti-Inflammatory with Enhancer Hesti Riasari; Revika Rachmaniar; Sri Wahyuni
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 2 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (425.863 KB) | DOI: 10.24198/ijpst.v6i2.18932

Abstract

Kencur (Kaempferia galanga L.) is a family of Zingiberaceae. Several studies have shown that kencur can help reduce inflammation because kencur is known to contain anti-inflammatory compounds, namely marker compounds from flavonoids, kaempferol. For the development of pharmaceutical preparations, research on anti-inflammatory plasters containing 96% ethanol extract, n-hexane extract, ethyl acetate extract and 70% ethanol extract from ginger rhizome with the addition of penetration enhancer (enhancer), namely propylene glycol. This anti-inflammatory plaster was tested for its activity in 5 groups of Wistar strain rat feet which had been induced 1% carrageenan (negative control); positive control (diclofenac sodium), ethanol96% extract, n-hexane extract, ethyl acetate extract and 70% ethanol extract from kencur rhizome and compared with plaster of kencur rhizome ethanol extract without enhancer. The results showed the effect of adding enhancers 30 minutes after administration. 96% ethanol extract and ethyl acetate extract had reduced inflammation by 79.99% in rat test animals compared to plaster ethanol extract of rhizome kencur without the addition of enhancers. Keywords :  Kaempferia galanga. L., patch, anti-inflammatory, enhancer, propylene glycol
Co-Authors Rachmaniar, Revika Sri Wahyuni