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Entris Sutisna
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Computer Science & IT Medicine & Pharmacology

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Determination of Salbutamol and Guaifenesin in Mixture Using Zero- Crossing Wavelength Measurement Entris Sutisna; Farida Fauzia; Ida Musfiroh; Shelvy E Suherman
Indonesian Journal of Pharmaceutical Science and Technology Vol 2, No 2 (2015)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (644.279 KB) | DOI: 10.15416/ijpst.v2i2.7809

Abstract

A mixture of salbutamol and guaifenesin in syrup was analyzed using zero-crossing wavelength method. NaOH 0.1 N was selected as the solvent. Zero-crossing wavelength of salbutamol is 246.2 nm and guaifenesin is 270.2 nm. Results showed that the recovery of salbutamol and guaifenesin are 95.96% and 93.94%, respectively, while the coefficient of variance is 0.995% for salbutamol and 0.2087% for guaifenesin. Limit of detection of salbutamol and guaifenesin are 0.05528 ppm and 9.443 ppm, respectively, while limit of quantification are 0.18427 ppm and 31.477 ppm. We concluded that this method could be applied to determine salbutamol and guaifenesin in mixture. Keywords: Derivative spectrophotometry, guaifenesin, salbutamol, zero-crossing
Co-Authors Farida Fauzia Ida Musfiroh Shelvy E Suherman