Article Per Year (5 Year)
p-Index From 2021 - 2026
3.687
P-Index
This Author published in this journals
All Journal E-Jurnal Medika Udayana Jurnal Kedokteran Diponegoro WMJ (Warmadewa Medical Journal) Molecular and Cellular Biomedical Sciences (MCBS) J-Dinamika: Jurnal Pengabdian Kepada Masyarakat INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Pengabdian Masyarakat (ABDIRA) Indonesian Journal of Cancer Makara Journal of Science Ahmad Dahlan Medical Journal Folia Medica Indonesiana Jurnal Implementa Husada (JIH)
Putri, Rachma Greta Perdana
Department Of Histology, Faculty Of Medicine, Universitas Ahmad Dahlan, Yogyakarta, Indonesia
Aerospace Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

Published : 23 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 23 Documents
Search

 1   2   3 
ZEB1 is Negatively Correlated with E-Cadherin in Prostatic Anomaly Tissue Sari Eka Pratiwi; Sri Nuryani Wahyuningrum; Rachmagreta Perdana Putri; Danarto Danarto; Didik Setyo Heriyanto; Nur Arfian; Sofia Mubarika Haryana; Indwiani Astuti
Molecular and Cellular Biomedical Sciences Vol 6, No 1 (2022)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v6i1.220

Abstract

Background: Prostatic anomalies are common in tumor or infection condition. The enlargement of prostate gland affects the epithelial cell polarity that involves epithelial-mesenchymal transition (EMT). Transition into mesenchymal is mediated by transcription factor ZEB1 and E-cadherin protein. Upregulation of ZEB1 and loss of E-Cadherin expression were associated to proliferation and metastasis of malignancy cells. This study aims to describe the correlation of ZEB1 and E-cadherin expression in prostatic anomaly.Materials and method: Samples were Formalin Fixed Paraffin Embedded (FFPE) block consist of 8 block Benign Prostatic Hyperplasia (BPH), 6 blocks High Grade Prostatic Intraepithelial Neoplasia (HGPIN) and 6 blocks Prostate Carcinoma (PCA). The blocks then sliced into 5 sections to be prepared for RNA extraction procedures. ZEB1 and E-Cadherin expression was analyzed by semi-quantitative procedures using PCR and electrophoresis. Correlation between ZEB1 and E-Cadherin espression was analyzed using Spearman’s rank correlation.Results: Relative expression of ZEB1 and E-cadherin mRNA in each group of prostatic anomaly were not significantly different (p>0.05). ZEB1 and E-Cadherin mRNA expression showed a significant and moderate level of negative correlation (p<0.05; 0.40 < r < 0.59). Increasing of ZEB1 mRNA expression will be followed by decreasing of E-Cadherin mRNA expression.Conclusion: ZEB1 negatively correlates with E-cadherin due to EMT process in prostatic anomaly. High expression of ZEB1 induced down-regulation of E-cadherin and vise versa. Various studies can be developed, especially the development of targeted therapy against ZEB1 to suppress the EMT process by increasing the expression of E-cadherin.Keywords: epithelial-mesenchymal transition (EMT), ZEB1, E-Cadherin, BPH, HGPIN, PCA
Risk Factor for Erythropoietin Resistance in Hemodialysis Patient : Literature Review Rachma Greta Perdana Putri; Amanatus Sholikhah; Novi Sukirto
Ahmad Dahlan Medical Journal Vol. 1 No. 2 (2020): November 2020
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1419.976 KB) | DOI: 10.12928/admj.v1i2.3131

Abstract

Anaemia become the complication of chronic kidney disease (CKD) which was caused by decreasing of erythropoietin. Erythropoietin stimulating agent (ESA) therapy is one of therapy to overcome the problem, but until 34% of patients have lack of response to ESA treatment. Anaemia in CKD related to the worsen of the diseases, quality of life, and mortality of patients. Decreasing of the response to erythropoietin need to be evaluated to correct anaemic condition. This review is aim to explain the risk factor for erythropoietin resistance. The literature for this review was collected through PUBMED and google scholar. Erythropoietin is glycoprotein secreted 90% by interstitial cells of kidney and 10% by liver cells. The functions of erythropoietin are stimulate the proliferation and cells differentiation in bone marrow, and enhance erythropoiesis. Renal damage can inhibit the secretion of erythropoietin. In patients with ESA treatment, risk factors for resistance are iron deficiency, inadequate haemodialysis, inflammation, hyperparathyroid, nutrition disturbance, antibody mediated Pure Red Cell Aplastic (PRCA). The risk factor can be influenced by genetic variation. Conclusion of this review, there are several factor that influence the response of erythropoietin in hemodialisa patients. Hence, study related anaemia in CKD need further study to optimalize the treatment.
Vitamin K and The Immune System Rachma Greta Perdana Putri; Rosyida Awalia Safitri; Yuni Herliyanti
Ahmad Dahlan Medical Journal Vol. 3 No. 1 (2022): May 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1648.541 KB) | DOI: 10.12928/admj.v3i1.6237

Abstract

Vitamin K is a vitamin fat-soluble with the main function as an anticoagulant. The active form of vitamin K can be divided into two categories, namely vitamin K1 (phylloquinone) can be found in photosynthetic plants and vitamin K2 (menaquinone) comes from bacteria, source in foods we can found this in fermented foods like natto or soybean product which fermented by Bacillus natto. This literature review was conducted through searching in database like PubMed, and Elsevier using keywords like vitamin K, Immune system, and inflammation. The role of vitamin K in physiological functions is well known worldwide, such as blood coagulation, bone metabolism, and regulation of several types of enzymes. Apart from this role, vitamin K also acts as a cofactor in several plasma proteins, so this vitamin can influence immune responses. Recent studies have found vitamin K links to inflammatory diseases. Vitamin K also induced autophagy pathway. However, information regarding the role of vitamin K in the immune system is limited.
Pelatihan Bantuan Hidup Dasar di Pesantren Mahasiswa Aqwamu Qila Tamanan Banguntapan Bantul Ario Tejosukmono; Dewi Yuniasih; Moch. Junaidy Heriyanto; Muhammad Agita Hutomo; Annisa Annisa; Rachma Greta Perdana Putri
Jurnal Pengabdian Masyarakat (ABDIRA) Vol 3, No 1 (2023): Abdira, Januari
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdira.v3i1.270

Abstract

Basic life support (BHD) is an effort needed to save the lives of victims while waiting for professional help to arrive. Basic life support knowledge and skills are needed by all groups. Santri at the Aqwamu Qila Banguntapan student boarding school has never received exposure and training related to basic life support. This PKM activity aims to provide understanding and skills to students related to BHD. The PKM activity was held on Sunday, August 28 at the Aqwamu Qila Mosque, consisting of BHD counseling and training with presentations and BHD video screenings, and manikin simulations. After the presentation and video screening, the training participants were divided into 2 groups, male and female, to directly practice and simulate BHD on the manikin. The result of this training is that all participants understand and are more confident in doing BHD. By directly carrying out a simulation on a manikin, participants can immediately practice how to provide basic life assistance.
Maternal characteristics and delivery method in patients with preeclampsia in PKU Muhammadiyah Bantul, Yogyakarta Irfan Rahmatullah; Rachma Greta Perdana Putri; Tiara Ismirahmadani; Novi Sukirto
Ahmad Dahlan Medical Journal Vol. 4 No. 1 (2023): May 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Preeclampsia is the condition of pregnancy that has high mortality of mother and result some complication for the childbirth. The incidence of preeclampsia in the world reaches 10% whereas 3% -5% of them experience complications of eclamptic pregnancy. The objective of this study was to explore maternal characteristics and delivery methods of preeclampsia in order to predict the prognosis of the diseases and direct proper antenatal care. Methods: the study was Descriptive observational with a cross-sectional design at PKU Muhammadiyah Bantul during 2018-2020. Data were collected from medical records. The variables was compared using the Mann-whitney, kruskall wallis, and crosstabs as appropriate. Results: In this study, we found 77 women. Majority of patient’s age are less than 35 years old, 5 patients (6.50%) were mild preeclampsia and 52 patients (67.50%) were severe preeclampsia. Forty seven (61.04%) patients with preeclampsia were multigravida and 37 patients (48.05%) have normal BMI. Almost all patients without comorbid disease (96.10%) and history of preeclampsia (98.70%). Sixty eight patients (88.31%) have interpregnancy interval less than 5 years and without complication after delivery. Preeclampsia’s patients delivered at aterm gestational age (67.53%). Significantly, delivery method of the patients were cesarean section (74.03%; p = 0.01%).
The Relationship between Nutritional Status and Menstrual Cycle among Medical Students at Ahmad Dahlan University Putri Dangga, Vathana Az Zahra; Putri, Rachma Greta Perdana; Rahmatullah, Irfan
E-Jurnal Medika Udayana Vol 13 No 4 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i04.P02

Abstract

Menstruation is the monthly shedding of the functional layer of the endometrium in the uterus that occurs when ovulation is not followed by fertilization. Menstrual irregularities occur due to hormonal disturbances caused by stress, excessive exercise, medication use, approaching menopause, eating disorders, and nutritional status such as underweight and obesity. Nutrition refers to the nutrients present in food that are required by the body to obtain energy for daily activities. Nutritional problems arise from an imbalance between the nutrients consumed and those needed by the body. To examine the relationship between nutritional status and menstrual cycles in students of the Faculty of Medicine, Ahmad Dahlan University, a research study was conducted using an observational analytical method with a cross-sectional approach. The research sample consisted of 131 students. Statistical analysis using chi-square analysis showed a p-value of 0.001, which is smaller than ? = 0.05. From these results, it can be concluded that there is a relationship between body mass index and upper arm circumference with the menstrual cycles of students in the Faculty of Medicine, Ahmad Dahlan University, while there is no relationship between waist circumference, waist-to-hip ratio, subcutaneous fat, and menstrual cycles in students of the Faculty of Medicine, Ahmad Dahlan University.
Major Microbiota Profile of Breast Cancer From Faecal Specimen and Cancerous Breast Tissue: A Comprehensive Systematic Review Annisa, Annisa; Perdana Putri, Rachma Greta; Solikhah, Solikhah
Indonesian Journal of Cancer Vol 17, No 4 (2023): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i4.1030

Abstract

Background: The microbiota population in breast cancer tissue is known to have a crucial role in the tumor microenvironment supporting developmental ability. Despite a heterogeneous profile, the relationship between microbiota and breast cancer is still not fully understood. Therefore, this study aimed to explain the major microbiota profile associated with breast cancer and explore potential biological connections Methods: Following the PRISMA guidelines, the literature review investigated the diverse composition of microbiota profiles in breast cancer patients compared to those in normal conditions. Utilizing the PICO framework, a comprehensive search was conducted on the Pubmed and Google Scholar databases. The searches were restricted to open-access articles from the last 5 years. Additionally, critical appraisals are conducted for quality assessment. Results: A total of 145 articles were identified using the relevant keywords, out of which 17 successfully passed filtering and screening for inclusion in the review. Major microbiota observed in breast cancer patients included firmicutes, proteobacteria, actinobacteria, and bacteroidetes. The microbiota profile was influenced by factors such as cancer subtype, menopausal history, and tumor severity. These microorganisms play a role in the inflammatory response to their metabolite products and modulate hormonal changes, potentially enhancing tumor survival. Conclusions: Generalizing the expression of microbiota profile both in the gut or its tissue might be challenging due to its multifactorial nature, dependent on patient characteristics such as age, menopausal status, BMI, tumor grade, and subtype. The study suggests that the major microbiota that shows increased prevalence in breast cancer include firmicutes, proteobacteria, actinobacteria, bacteroidetes, and blautia, each playing a distinct role in the developmental process. 
The Effect of Health Education on Knowledge of the Dangers of Smoking in Students of SMK Negeri 4 Yogyakarta Prisilla Maya Heni Pratiwi; Putri, Rachma Greta Perdana; Sukirto, Novi Wijayanti; Astuti, Fardhiasih Dwi
Ahmad Dahlan Medical Journal Vol. 5 No. 1 (2024): May 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Smoking is the activity of smoking tobacco rolls wrapped in paper or nipa leaves and then burning and producing smoke. In thesurvey results of the Ministry of Health of the Republic of Indonesia, the risk of smoking behavior in junior and senior high school students in Indonesia in 2015 was 32.82% in male students. Smoking habits lead to health risk for cardiovascular and respiratory diseases and many types of cancer. Smokers have moderate knowledge of tobacco. The study's aim is to examine the effect of health education on knowledge of the dangers of smoking in students of SMK Negeri 4 Yogyakarta. This study utilized a pre-experimental design method with One-Group Pretest-Posttest design approach. The study sample consisted of 127 students who met inclusion and exclusion criteria in class X students of SMK Negeri 4 Yogyakarta. The pretest and post-test scores varied from 22 to 29 with increased scores of the post-test’s trend. Statistical analysis using chi-square test analysis showed a p-value of 0.000 (<0.05). These results suggest that there is an influence between health education on knowledge of the dangers of smoking in students of SMK Negeri 4 Yogyakarta
Management of Sodium Imbalance Purwanto, Barkah Djaka; Perdana Putri, Rachma Greta
Ahmad Dahlan Medical Journal Vol. 5 No. 1 (2024): May 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Sodium imbalance consists of hyponatremia and hypernatremia. Acute and severe hyponatremia and hypernatremia are life-threatening conditions. Rapid and slow correction should be considered for optimal outcomes, as aggressive management is often associated with the danger of demyelination and cerebral edema. This review aims to determine the safe management of sodium imbalance so that it is hoped that in overcoming critical conditions it does not transfer to other critical conditions that are equally fatal. The data search strategy uses the PubMed and Google Scholar databases between 2010 and 2022 with free full text that can be downloaded. The findings emphasize that acute and severe hyponatremia and hypernatremia are often life-threatening conditions. Management of these conditions requires caution, as aggressive correction in hyponatremia can result in osmotic demyelination, while hypernatremia can lead to cerebral edema. Despite theoretical risks, the study found no significant difference in 30-day mortality, seizures, cerebral edema, or decreased consciousness between fast and slow correction methods. The conclusion underscores the importance of tailored and cautious management strategies to mitigate the risks associated with sodium imbalance corrections.
Level of physical fitness of member of Indonesian Medical Association in Bantul, Yogyakarta Ihsana, Nuni; Yuniasih, Dewi; Putri, Rachma Greta Perdana; Annisa, Annisa; Tejosukmono, Ario; Heriyanto, Mochammad Junaidy; Pamungkasih, Wahyu; Rokhmah, Budi Nur; Murdiyanto, Joko
Ahmad Dahlan Medical Journal Vol. 5 No. 1 (2024): May 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Physical inactivity contributed to 7.2% of all-cause mortality. Many research demonstrates that the integration of physical activity and exercise into daily routine prevents chronic disease and lowers mortality. This study aims to assess the physical fitness of members of the Indonesian Medical Association in the Bantul region using a descriptive from secondary data. The subjects were 38 members of the Indonesian Medical Association. Physical fitness data was obtained using the Rockport One Mile Walking Test. Body Mass Index (BMI) is also calculated to describe excessive body fat. The majority of participants are female (52.63%) and participants dominant age ranged between 19 and 44 years old (50%). The participants aged 18 years old showed good physical fitness. The results in participants aged 19 to 44 years were more varied, there were 8 participants, 7 participants, 3 participants 1 participant had fair, good, poor, and very poor physical fitness, respectively. Physical fitness in participants aged 45 to 59 years were 9 and 5 participants showed good and fair physical fitness, respectively. The subjects aged >59 years old have 2 people with good physical fitness and 1 person with fair physical fitness. None of the participants with BMI status underweight, normal weight, or overweight showed poor physical fitness, while participants with obesity had poor and very poor physical fitness. Physical fitness is a multidimensional concept and is related to regular activity.
Co-Authors Alim, Ahmad Muttaqin Amanatus Sholikhah Andrianto Selohandono Annisa Annisa Annisa Annisa Ario Tejosukmono Ario Tejosukmono Ario Tejosukmono Arliono, Tri Yunanto Asarizq Fatihah Rasjava Danarto Danarto Danarto Danarto Danian, Muhamad Dewi Yuniasih Dewi Yuniasih Dewi Yuniasih Dewinta, Mustika Cahya Nirmala Didik Setyo Heriyanto Dwi Utami Emelia, Dwi Ditha Eureka Raihan Asqy Dendy Fadhila, Rais Fardhiasih Dwi Astuti Heriyanto, Mochammad Junaidy Hutomo, Muhammad Agita Ihsana, Nuni Imam Masduki Indarto, Bayu Praditya Indwiani Astuti Indwiani Astuti Intan Dyah Prawesti Irfan Rahmatullah Katrina Rizky Salsabila Khoiru Nisa, Afifah Leonny Dwi Rizkita Leonny Dwi Rizkita Maulana Faris Ikhzul Haq Moch. Junaidy Heriyanto Muhammad Agita Hutomo Muhammad Farid Muhammad Faris Nafiuzzaqi murdiyanto, joko Novi Wijayanti Sukirto Nur Arfian Nurcholid Umam Kurniawan Nurul Qomariyah Oktomi Wijaya Pamungkasih, Wahyu Prameswari, Adilla Soraya Prisilla Maya Heni Pratiwi Purwanto, Barkah Djaka Putra, Fadly Muhammad Bima Putri Dangga, Vathana Az Zahra Rahmatullah, Irfan Reza, Anggit Rokhmah, Budi Nur Rosyida Awalia Safitri Sari Eka Pratiwi Septian Emma Dwi Shafa Zahra Salsabila Sofia Mubarika Haryana Solikhah Solikhah Sompokan, Ruendhita Azzahra Sari Sri Nuryani Wahyuningrum Sri Nuryani Wahyuningrum Sukirto, Novi Wijayanti Tianotak, Muhammad Tri Yoga Tiara Ismirahmadani Tira Alfiani Laariya Ulfa, MH Muflihatul Wijaya, Adi Indra Wildan Fandi Farihan Yuni Herliyanti Yuniasih, Dewi