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WAHYU JOKOPRIYAMBODO
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Variation Of Andrographolite Conten From Sambiloto (Andrographis paniculata Ness) Which Grow In Various Regions WAHYU JOKOPRIYAMBODO
Biota Vol 6 No 1 (2020): Jurnal Biota 2020
Publisher : Faculty of Science and Technology Universitas Islam Negeri Raden Fatah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/Biota.v6i1.4882

Abstract

Sambiloto is used as a hepatoprotector, enhancing the immune system, antidiabetic, anti-inflammatory, antiomalaria, antidiarrheal and many more. One of the main ingredients of the bitter plant is andrographolite. This plant is widely spread throughout Indonesia ranging from lowlands to high plains with various types of soil and altitude. The existence of this fairly wide distribution can give effect to the content of andrographolite, so that in this study will be studied about variations in andrographolite levels source from various regions. The results of this study will be used as a quality reference for treatment based on andrographolite. Samples of bitter plants are taken from various regions. Furthermore, parts of plants that are above the ground are separated between leaves, twigs and stems. All samples were dried in an oven at 60 degrees Celsius. Pollinated samples were then sieved. Samples were extracted with ethanol overnight and then analyzed their andrographolite levels with TLC-densitometry.The results of the analysis of andrographolite levels showed that bitter from various regions have different levels. Tthe organs of plants also show different levels of andrographolite as well. Part of the leaf organ is the part that contains the most andrographolite.
POTENSI EKSTRAK DAUN PALIASA (Kleinhovia hospita) SEBAGAI ANTI Plasmodium falciparum Mery Budiarti; Wahyu Jokopriyambodo
Buletin Penelitian Tanaman Rempah dan Obat Vol 31, No 2 (2020): Buletin Penelitian Tanaman Rempah dan Obat
Publisher : Pusat Penelitian dan Pengembangan Perkebunan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21082/bullittro.v31n2.2020.85-96

Abstract

Paliasa (Kleinhovia hospita) dikenal sebagai salah satu jenis tumbuhan yang telah digunakan secara empiris sebagai obat malaria terutama di bagian Timur Indonesia. Namun, publikasi ilmiah terkait aktivitas antiplasmodium bahan alam tersebut masih sangat terbatas. Penelitian ini bertujuan untuk menguji potensi antiplasmodium dari daun paliasa terhadap parasit Plasmodium falciparum. Tahapan penelitian meliputi persiapan sampel dan ekstrak, pengujian aktivitas antiplasmodium secara in vitro pada P. falciparum strain 3D7, dan penapisan fitokimia menggunakan Kromatografi Lapis Tipis (KLT). Sampel penelitian berupa ekstrak dan fraksi diperoleh melalui proses maserasi selama 3 x 24 jam dalam pelarut etanol pro analysis, kemudian dilanjutkan dengan partisi cair-cair bertingkat menggunakan pelarut heksana, etil asetat dan metanol pro analysis. Pengujian antiplasmodium in vitro menunjukkan fraksi etil asetat (IC50 1,08 µg.ml-1) dan heksana (IC50 3,69 µg.ml-1) memiliki aktivitas dengan kategori sangat aktif. Penapisan fitokimia daun paliasa menunjukkan adanya kandungan senyawa alkaloid, triterpenoid dan steroid. Senyawa alkaloid terpenoid berupa sikloartane triterpenoid alkaloid.  Daun paliasa diduga berperan aktif sebagai senyawa antiplasmodium.  Namun, perlu dilakukan pengkajian lebih lanjut untuk memastikan jenis senyawa aktif tersebut serta mekanismenya sebagai antiplasmodium
Co-Authors Mery Budiarti