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Irianiwati Irianiwati
Department of Pathology of Anatomy, Faculty of Medicine, University of Gadjah Mada
Immunology & microbiology Neuroscience

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Molecular subtypes and clinicopathological features of breastcancer Irianiwati, Irianiwati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 45, No 01 (2013)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (86.942 KB) | DOI: 10.19106/JMedScie004501201306

Abstract

Breast cancer is a heterogeneous disease with regard to morphological spectrum, clinical presentation and response to therapy. Based on immunohistochemistry detection of estrogen receptor, progesterone receptor, Her-2 status, proliferation rate and clusters of basal gene expression, breast cancers can be classified into luminal A, luminal B, basal-like/triple negative, and Her-2 positive. It was suggested that there was a close relationship between molecular subtypes and clinicopathological features of breast cancer, as they are very important to predict prognosis and therapeutic implications. Keywords: molecular subtypes - breast cancer- clinicopathological features -heterogeneity –theraputicimplications  
The role of tumor-associated macrophages in breast cancer Irianiwati, Irianiwati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 01 (2011)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (84.206 KB)

Abstract

Interaction of Tumor-Associated Macrophages (TAMs) with tumor cells gives insights into tumor progression andinto a novel therapeutic strategy. In papillary thyroid cancer, patients with tumors containing TAMs had a betterprognosis than patients without TAMs . In prostatic cancer, the reduced of total TAMs can be used as a novelprognostic marker. In melanoma maligna, high number of TAMs was statistically significant associated with poorresponse to treatment . In breast cancer progression, the role of TAMs is still unclear.Key words: tumor-associated macrophages - breast cancer – angiogenesis - tumor progression - prognosis
The basal membrane destruction in benign prostatic hyperplasia, prostatic intraepithelial neoplasma, and prostatic adenocarcinoma. A study on basal membrane type IV collagens Irianiwati, Irianiwati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 01 (1997)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (381.615 KB)

Abstract

Basal membrane (BM), a selective permeable membrane is mainly composed of type IV collagen. A tumor invasion, therefore, may only occur if this membrane is destroyed by an active process of tumor producing proteolytic enzymes. It has been found that prostatic intraepithelial neoplasia (PIN) is a prostatic premalignant lesion. Although both benign prostate hyperplasia (BPH) and prostatic adenocarcinoma required an androgenic hormone for their growth, the correlation between the degree of destruction of basal membranes and BPH, PIN, and prostatic adenocarcinoma should be clarified. This can be studied by observing the continuity of periacinair BM. In order to understand the correlation among prostatic lesions, the BM continuity of 40 paraffin block specimens (15 BPH, 11 PIN, and 14 Prostatic adenocarcinomas) were studied. The BM of these specimens were stained immunohistochemically with MoAB anti human Type IV collagens. The periacinair BM continuity was scored 0-5. The Spearmans correlation test was used to analyze their possible relationship.The result shows that there is a significant correlation between the degree of destruction of basal membranes and BPH, PIN, and Prostatic adenocarcinomas (r = 0.898; p<0.05). In conclusion, based on periacinair BM des-truction, there is a positive correlation between the degree of destruction of basal membranes and BPH, PIN, and prostatic adenocarcinomas.Key words : collagen type IV - prostatic adenocarsinoma - prostatic intrapithelial neoplasia - benign prostate hyperplasia - basal membrane
Ekspresi protein P53 pada hiperplasi prostat benigna, prostatic intraepithelial neoplasia dan adenokarsinoma prostat Irianiwati, Irianiwati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 31, No 02 (1999)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: The mutant type of p53 protein looses its ability to inhibit cell proliferation and the increase of this protein expression has been detected among several human cancers. The p53 mutant protein is stable and therefore can be detected by immunohistochemical technique. The over expression of p53 in the several prostatic lesions has widely been investigated but the result is still controversial. The relation between p53 expression with the histological grading of the prostatic lesions is still unclear.Objective: To study the correlation between p53 expression with the histological grading of the prostatic lesions.Methods: Sixty two paraffin blocks of specimens which were diagnosed as benign prostate hyperplasia, prostatic intraepithelial neoplasia, and adenocarcinoma of the prostates collected from several anatomic pathology laboratories in 'Yogyakarta were chosen. Specimens containing heavy inflamatory cells and necrotic tissues were excluded from this study. The chosen specimens were reexamined and histological malignant grading were also determined. The specimens were then stained with p53 MoAb-DO-7 (DAKO) immunohistochemically and the score of p53 positive cells, p53 intensity, the distribution of p53 positive cells, and total expression of p53 were determined among them. The correlation between malignant grading and those scores were analyzed by defining the correlation coefficient of Spearman.Results: There was a weak significant correlation 
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